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Science 11 December 1992:
Vol. 258. no. 5089, pp. 1798 - 1801
DOI: 10.1126/science.1281554

Articles

Science, Vol 258, Issue 5089, 1798-1801
Copyright © 1992 by American Association for the Advancement of Science


articles

Interleukin-8 as a macrophage-derived mediator of angiogenesis

AE Koch, PJ Polverini, SL Kunkel, LA Harlow, LA DiPietro, VM Elner, SG Elner, and RM Strieter

Department of Medicine, Northwestern University Medical School, Chicago, IL 60611.

Angiogenic factors produced by monocytes-macrophages are involved in the pathogenesis of chronic inflammatory disorders characterized by persistent angiogenesis. The possibility was tested that interleukin-8 (IL-8), which is a cytokine that is chemotactic for lymphocytes and neutrophils, is also angiogenic. Human recombinant IL-8 was potently angiogenic when implanted in the rat cornea and induced proliferation and chemotaxis of human umbilical vein endothelial cells. Angiogenic activity present in the conditioned media of inflamed human rheumatoid synovial tissue macrophages or lipopolysaccharide-stimulated blood monocytes was equally blocked by antibodies to either IL-8 or tumor necrosis factor-alpha. An IL-8 antisense oligonucleotide specifically blocked the production of monocyte-induced angiogenic activity. These data suggest a function for macrophage-derived IL-8 in angiogenesis-dependent disorders such as rheumatoid arthritis, tumor growth, and wound repair.


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J. Biol. Chem. 280, 2888-2895
   Abstract »    Full Text »    PDF »
IL-8 and its CXCR1 and CXCR2 receptors participate in the control of megakaryocytic proliferation, differentiation, and ploidy in myeloid metaplasia with myelofibrosis.
S. Emadi, D. Clay, C. Desterke, B. Guerton, E. Maquarre, A. Charpentier, C. Jasmin, M.-C. Le Bousse-Kerdiles, and for the French INSERM Research Network on MMM (2005)
Blood 105, 464-473
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A Review of the Role of Proinflammatory Cytokines in Labor and Noninfectious Preterm Labor.
L. Farina and C. Winkelman (2005)
Biol Res Nurs 6, 230-238
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Novel roles of the autocrine motility factor/phosphoglucose isomerase in tumor malignancy.
T Yanagawa, T Funasaka, S Tsutsumi, H Watanabe, and A Raz (2004)
Endocr. Relat. Cancer 11, 749-759
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Bartonella Adhesin A Mediates a Proangiogenic Host Cell Response.
T. Riess, S. G.E. Andersson, A. Lupas, M. Schaller, A. Schafer, P. Kyme, J. Martin, J.-H. Walzlein, U. Ehehalt, H. Lindroos, et al. (2004)
J. Exp. Med. 200, 1267-1278
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Increased Serum Interleukin-8 in Patients with Early and Metastatic Breast Cancer Correlates with Early Dissemination and Survival.
I. H. Benoy, R. Salgado, P. Van Dam, K. Geboers, E. Van Marck, S. Scharpe, P. B. Vermeulen, and L. Y. Dirix (2004)
Clin. Cancer Res. 10, 7157-7162
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Chemokines: Key Regulators of Mononuclear Cell Recruitment in Atherosclerotic Vascular Disease.
C. Weber, A. Schober, and A. Zernecke (2004)
Arterioscler. Thromb. Vasc. Biol. 24, 1997-2008
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Gene Expression Profiling of Tumor-Stromal Interactions between Pancreatic Cancer Cells and Stromal Fibroblasts.
N. Sato, N. Maehara, and M. Goggins (2004)