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Science 11 December 1992:
Vol. 258. no. 5089, pp. 1804 - 1808
DOI: 10.1126/science.1465618
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Articles
Science, Vol 258, Issue 5089, 1804-1808
Copyright © 1992 by American Association for the Advancement of Science
Expression directed from HIV long terminal repeats in the central nervous system of transgenic mice
Corboy JR,
JM Buzy,
MC Zink,
and
JE Clements
Division of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Infection with the human immunodeficiency virus (HIV) is frequently accompanied by the AIDS (acquired immunodeficiency syndrome) dementia complex. The role of specific HIV genetic elements in the pathogenesis of central nervous system (CNS) disease is not clear. Transgenic mice were constructed that contained the long terminal repeats (LTRs) of two CNS-derived strains and a T cell tropic strain of HIV-1. Only mice generated with CNS-derived LTRs directed expression in the CNS, particularly in neurons. Thus, some strains of HIV-1 have a selective advantage for gene expression in the brain, and neurons can supply the cellular factors necessary for their transcription.
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