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Science 11 December 1992:
Vol. 258. no. 5089, pp. 1812 - 1815
DOI: 10.1126/science.1465619
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Articles

Science, Vol 258, Issue 5089, 1812-1815
Copyright © 1992 by American Association for the Advancement of Science

articles

Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate

NL Allbritton, T Meyer, and L Stryer

Department of Cell Biology, Stanford University, CA 94305.

The range of messenger action of a point source of Ca2+ or inositol 1,4,5-trisphosphate (IP3) was determined from measurements of their diffusion coefficients in a cytosolic extract from Xenopus laevis oocytes. The diffusion coefficient (D) of [3H]IP3 injected into an extract was 283 microns 2/s. D for Ca2+ increased from 13 to 65 microns 2/s when the free calcium concentration was raised from about 90 nM to 1 microM. The slow diffusion of Ca2+ in the physiologic concentration range results from its binding to slowly mobile or immobile buffers. The calculated effective ranges of free Ca2+ before it is buffered, buffered Ca2+, and IP3 determined from their diffusion coefficients and lifetimes were 0.1 micron, 5 microns, and 24 microns, respectively. Thus, for a transient point source of messenger in cells smaller than 20 microns, IP3 is a global messenger, whereas Ca2+ acts in restricted domains.


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