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Science 18 December 1992:
Vol. 258. no. 5090, pp. 1935 - 1938
DOI: 10.1126/science.1470916
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Articles

Science, Vol 258, Issue 5090, 1935-1938
Copyright © 1992 by American Association for the Advancement of Science

articles

Cellular proteins bound to immunodeficiency viruses: implications for pathogenesis and vaccines

LO Arthur, JW Bess Jr, RC Sowder 2nd, RE Benveniste, DL Mann, JC Chermann, and LE Henderson

AIDS Vaccine Program, National Cancer Institute, Frederick Cancer Research and Development Center NCI-FCRDC, MD 21702.

Cellular proteins associated with immunodeficiency viruses were identified by determination of the amino acid sequence of the proteins and peptides present in sucrose density gradient-purified human immunodeficiency virus (HIV)-1, HIV-2, and simian immunodeficiency virus (SIV). beta 2 microglobulin (beta 2m) and the alpha and beta chains of human lymphocyte antigen (HLA) DR were present in virus preparations at one-fifth the concentration of Gag on a molar basis. Antisera to HLA DR, beta 2 m, as well as HLA class I precipitated intact viral particles, suggesting that these cellular proteins were physically associated with the surface of the virus. Antisera to class I, beta 2m, and HLA DR also inhibited infection of cultured cells by both HIV-1 and SIV. The specific, selective association of these cellular proteins in a physiologically relevant manner has major implications for our understanding of the infection process and the pathogenesis of immunodeficiency viruses and should be considered in the design of vaccines.


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   Abstract »    Full Text »    PDF »
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R. A. Weldon Jr., W. B. Parker, M. Sakalian, and E. Hunter (1998)
J. Virol. 72, 3098-3106
   Abstract »    Full Text »    PDF »
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C. Casoli, M. C. Re, P. Monari, G. Furlini, G. Tosi, C. Gradozzi, P. P. Dall'Aglio, U. Bertazzoni, and R. S. Accolla (1998)
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   Abstract »    Full Text »    PDF »
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L. Chiarantini, D. Matteucci, M. Pistello, U. Mancini, P. Mazzetti, C. Massi, S. Giannecchini, I. Lonetti, M. Magnani, and M. Bendinelli (1998)
Clin. Vaccine Immunol. 5, 235-241
   Abstract »    Full Text »
Infectious Cellular Load in Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Individuals and Susceptibility of Peripheral Blood Mononuclear Cells from Their Exposed Partners to Non-Syncytium-Inducing HIV-1 as Major Determinants for HIV-1 Transmission in Homosexual Couples.
H. Blaak, A. B. van't Wout, M. Brouwer, M. Cornelissen, N. A. Kootstra, N. Albrecht-van Lent, R. P. M. Keet, J. Goudsmit, R. A. Coutinho, and H. Schuitemaker (1998)
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   Abstract »    Full Text »    PDF »
Thioltransferase (Glutaredoxin) Is Detected Within HIV-1 and Can Regulate the Activity of Glutathionylated HIV-1 Protease in Vitro.
D. A. Davis, F. M. Newcomb, D. W. Starke, D. E. Ott, J. J. Mieyal, and R. Yarchoan (1997)
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The Human Immunodeficiency Virus Type 1 (HIV-1) Vpu Protein Interferes with an Early Step in the Biosynthesis of Major Histocompatibility Complex (MHC) Class I Molecules.
T. Kerkau, I. Bacik, J. R. Bennink, J. W. Yewdell, T. Hunig, A. Schimpl, and U. Schubert (1997)
J. Exp. Med. 185, 1295-1306
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B. S. Graham and P. F. Wright (1995)
N. Engl. J. Med. 333, 1331-1339
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Human Immunodeficiency Virus.
L. O. Arthur, L. E. Henderson, R. E. Benveniste, and D. M. Phillips (1995)
N. Engl. J. Med. 332, 1719
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Alloimmunization as an AIDS vaccine?.
G. Shearer, M Clerici, and A Dalgleish (1993)
Science 262, 161-162
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Scientific and social issues of human immunodeficiency virus vaccine development.
B. Haynes (1993)
Science 260, 1279-1286
   Abstract »    PDF »
Protection against vaginal SIV transmission with microencapsulated vaccine.
P. Marx, R. Compans, A Gettie, J. Staas, R. Gilley, M. Mulligan, G. Yamshchikov, D Chen, and J. Eldridge (1993)
Science 260, 1323-1327
   Abstract »    PDF »
High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR.
M Piatak Jr, M. Saag, L. Yang, S. Clark, J. Kappes, K. Luk, B. Hahn, G. Shaw, and J. Lifson (1993)
Science 259, 1749-1754
   Abstract »    PDF »
Explaining Puzzling Vaccine Results.
J. Cohen (1992)
Science 258, 1881
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Attachment of Human Immunodeficiency Virus-1 (HIV-1) Particles Bearing Host-encoded B7-2 Proteins Leads to Nuclear Factor-kappa B- and Nuclear Factor of Activated T Cells-dependent Activation of HIV-1 Long Terminal Repeat Transcription.
S. Bounou, N. Dumais, and M. J. Tremblay (2001)
J. Biol. Chem. 276, 6359-6369
   Abstract »    Full Text »    PDF »
Directing the Immune Response to Carbohydrate Antigens.
G. Cunto-Amesty, T. K. Dam, P. Luo, B. Monzavi-Karbassi, C. F. Brewer, T. C. Van Cott, and T. Kieber-Emmons (2001)
J. Biol. Chem. 276, 30490-30498
   Abstract »    Full Text »    PDF »
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L. VerPlank, F. Bouamr, T. J. LaGrassa, B. Agresta, A. Kikonyogo, J. Leis, and C. A. Carter (2001)
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