Science 18 December 1992: Vol. 258. no. 5090, pp. 1946 - 1949 DOI: 10.1126/science.1470919

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Articles

Endocannabinoids and the Control of Energy Homeostasis.

G. Kunos, D. Osei-Hyiaman, J. Liu, G. Godlewski, and S. Batkai (2008)
J. Biol. Chem. 283, 33021-33025
 |  Abstract »  |  Full Text »  |  PDF »

N-Arachidonyl Maleimide Potentiates the Pharmacological and Biochemical Effects of the Endocannabinoid 2-Arachidonylglycerol through Inhibition of Monoacylglycerol Lipase.

J. J. Burston, L. J. Sim-Selley, J. P. Harloe, A. Mahadevan, R. K. Razdan, D. E. Selley, and J. L. Wiley (2008)
J. Pharmacol. Exp. Ther. 327, 546-553
 |  Abstract »  |  Full Text »  |  PDF »

Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis.

M Di Filippo, L A Pini, G P Pelliccioli, P Calabresi, and P Sarchielli (2008)
J. Neurol. Neurosurg. Psychiatry 79, 1224-1229
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Inhibiting parabrachial fatty acid amide hydrolase activity selectively increases the intake of palatable food via cannabinoid CB1 receptors.

N. V. DiPatrizio and K. J. Simansky (2008)
Am J Physiol Regulatory Integrative Comp Physiol 295, R1409-R1414
 |  Abstract »  |  Full Text »  |  PDF »

N-arachidonylethanolamide-Induced Increase in Aqueous Humor Outflow Facility.

Y. F. Njie, Z. Qiao, Z. Xiao, W. Wang, and Z.-H. Song (2008)
Invest. Ophthalmol. Vis. Sci. 49, 4528-4534
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Type-1 Cannabinoid Receptor During Rat Postnatal Testicular Development: Possible Involvement in Adult Leydig Cell Differentiation.

G. Cacciola, T. Chioccarelli, K. Mackie, R. Meccariello, C. Ledent, S. Fasano, R. Pierantoni, and G. Cobellis (2008)
Biol Reprod 79, 758-765
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Activating Parabrachial Cannabinoid CB1 Receptors Selectively Stimulates Feeding of Palatable Foods in Rats.

N. V. DiPatrizio and K. J. Simansky (2008)
J. Neurosci. 28, 9702-9709
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Identification of Novel Endogenous Cytochrome P450 Arachidonate Metabolites with High Affinity for Cannabinoid Receptors.

J.-K. Chen, J. Chen, J. D. Imig, S. Wei, D. L. Hachey, J. S. Guthi, J. R. Falck, J. H. Capdevila, and R. C. Harris (2008)
J. Biol. Chem. 283, 24514-24524
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Structure-guided inhibitor design for human FAAH by interspecies active site conversion.

M. Mileni, D. S. Johnson, Z. Wang, D. S. Everdeen, M. Liimatta, B. Pabst, K. Bhattacharya, R. A. Nugent, S. Kamtekar, B. F. Cravatt, et al. (2008)
PNAS 105, 12820-12824
 |  Abstract »  |  Full Text »  |  PDF »

The Endogenous Cannabinoid System Modulates Nicotine Reward and Dependence.

L. L. Merritt, B. R. Martin, C. Walters, A. H. Lichtman, and M. I. Damaj (2008)
J. Pharmacol. Exp. Ther. 326, 483-492
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Farnesyl Pyrophosphate and N-Arachidonylglycine as Endogenous Ligands for GPR92.

D. Y. Oh, J. M. Yoon, M. J. Moon, J.-I. Hwang, H. Choe, J. Y. Lee, J. I. Kim, S. Kim, H. Rhim, D. K. O'Dell, et al. (2008)
J. Biol. Chem. 283, 21054-21064
 |  Abstract »  |  Full Text »  |  PDF »

Thematic Review Series: Glycerolipids. Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids.

J. E. Vance (2008)
J. Lipid Res. 49, 1377-1387
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Palmitoylethanolamide on Signaling Pathways Implicated in the Development of Spinal Cord Injury.

T. Genovese, E. Esposito, E. Mazzon, R. D. Paola, R. Meli, P. Bramanti, D. Piomelli, A. Calignano, and S. Cuzzocrea (2008)
J. Pharmacol. Exp. Ther. 326, 12-23
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Therapeutic potential of cannabis in pain medicine.

R. D. Hosking and J. P. Zajicek (2008)
Br. J. Anaesth. 101, 59-68
 |  Abstract »  |  Full Text »  |  PDF »

Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells.

V. L. Hegde, S. Hegde, B. F. Cravatt, L. J. Hofseth, M. Nagarkatti, and P. S. Nagarkatti (2008)
Mol. Pharmacol. 74, 20-33
 |  Abstract »  |  Full Text »  |  PDF »

Beta-caryophyllene is a dietary cannabinoid.

J. Gertsch, M. Leonti, S. Raduner, I. Racz, J.-Z. Chen, X.-Q. Xie, K.-H. Altmann, M. Karsak, and A. Zimmer (2008)
PNAS 105, 9099-9104
 |  Abstract »  |  Full Text »  |  PDF »

N-Palmitoyl Glycine, a Novel Endogenous Lipid That Acts As a Modulator of Calcium Influx and Nitric Oxide Production in Sensory Neurons.

N. Rimmerman, H. B. Bradshaw, H. V. Hughes, J. S.-C. Chen, S. S.-J. Hu, D. McHugh, E. Vefring, J. A. Jahnsen, E. L. Thompson, K. Masuda, et al. (2008)
Mol. Pharmacol. 74, 213-224
 |  Abstract »  |  Full Text »  |  PDF »

Endocannabinoids in endocrine and related tumours.

M. Bifulco, A. M. Malfitano, S. Pisanti, and C. Laezza (2008)
Endocr. Relat. Cancer 15, 391-408
 |  Abstract »  |  Full Text »  |  PDF »

Role in Anxiety Behavior of the Endocannabinoid System in the Prefrontal Cortex.

T. Rubino, N. Realini, C. Castiglioni, C. Guidali, D. Vigano, E. Marras, S. Petrosino, G. Perletti, M. Maccarrone, V. Di Marzo, et al. (2008)
Cereb Cortex 18, 1292-1301
 |  Abstract »  |  Full Text »  |  PDF »

Anandamide Biosynthesis Catalyzed by the Phosphodiesterase GDE1 and Detection of Glycerophospho-N-acyl Ethanolamine Precursors in Mouse Brain.

G. M. Simon and B. F. Cravatt (2008)
J. Biol. Chem. 283, 9341-9349
 |  Abstract »  |  Full Text »  |  PDF »

Downregulation of the CB1 Cannabinoid Receptor and Related Molecular Elements of the Endocannabinoid System in Epileptic Human Hippocampus.

A. Ludanyi, L. Eross, S. Czirjak, J. Vajda, P. Halasz, M. Watanabe, M. Palkovits, Z. Magloczky, T. F. Freund, and I. Katona (2008)
J. Neurosci. 28, 2976-2990
 |  Abstract »  |  Full Text »  |  PDF »

Endocannabinoid system and its implications for obesity and cardiometabolic risk.

R. W. Nesto and K. Mackie (2008)
Eur. Heart J. Suppl. 10, B34-B41
 |  Abstract »  |  Full Text »  |  PDF »

The group IV afferent neuron expresses multiple receptor alterations in cardiomyopathyic rats: evidence at the cannabinoid CB1 receptor.

M. A. Williams, S. A. Smith, D. E. O'Brien, J. H. Mitchell, and M. G. Garry (2008)
J. Physiol. 586, 835-845
 |  Abstract »  |  Full Text »  |  PDF »

Enzymatic Machinery for Endocannabinoid Biosynthesis Associated with Calcium Stores in Glutamatergic Axon Terminals.

R. Nyilas, B. Dudok, G. M. Urban, K. Mackie, M. Watanabe, B. F. Cravatt, T. F. Freund, and I. Katona (2008)
J. Neurosci. 28, 1058-1063
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Characterization of a Novel Type of Prostamide/Prostaglandin F Synthase, Belonging to the Thioredoxin-like Superfamily.

H. Moriuchi, N. Koda, E. Okuda-Ashitaka, H. Daiyasu, K. Ogasawara, H. Toh, S. Ito, D. F. Woodward, and K. Watanabe (2008)
J. Biol. Chem. 283, 792-801
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Identification of biosynthetic precursors for the endocannabinoid anandamide in the rat brain.

G. Astarita, F. Ahmed, and D. Piomelli (2008)
J. Lipid Res. 49, 48-57
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Endocannabinoids, cannabinoid receptors and inflammatory stress: an interview with Dr. Pal Pacher.

H. F. Rosenberg (2007)
J. Leukoc. Biol. 82, 1390-1392
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CB1 Cannabinoid Receptor Activity Is Modulated by the Cannabinoid Receptor Interacting Protein CRIP 1a.

J. L. Niehaus, Y. Liu, K. T. Wallis, M. Egertova, S. G. Bhartur, S. Mukhopadhyay, S. Shi, H. He, D. E. Selley, A. C. Howlett, et al. (2007)
Mol. Pharmacol. 72, 1557-1566
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Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury.

R. Durst, H. Danenberg, R. Gallily, R. Mechoulam, K. Meir, E. Grad, R. Beeri, T. Pugatsch, E. Tarsish, and C. Lotan (2007)
Am J Physiol Heart Circ Physiol 293, H3602-H3607
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Adaptations of guest and host in expanded self-assembled capsules.

D. Ajami and J. Rebek Jr. (2007)
PNAS 104, 16000-16003
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The role of the endocannabinoid system in gametogenesis, implantation and early pregnancy.

A.H. Taylor, C. Ang, S.C. Bell, and J.C. Konje (2007)
Hum. Reprod. Update 13, 501-513
 |  Abstract »  |  Full Text »  |  PDF »

The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species.

S. V. Siegmund, T. Qian, S. de Minicis, J. Harvey-White, G. Kunos, K. Y. Vinod, B. Hungund, and R. F. Schwabe (2007)
FASEB J 21, 2798-2806
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for the Involvement of Cannabinoid CB1 Receptors in the Bimatoprost-Induced Contractions on the Human Isolated Ciliary Muscle.

M. R. Romano and M. D. Lograno (2007)
Invest. Ophthalmol. Vis. Sci. 48, 3677-3682
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Anandamide and Noxious Heat on Intracellular Calcium Concentration in Nociceptive DRG Neurons of Rats.

T. Fischbach, W. Greffrath, H. Nawrath, and R.-D. Treede (2007)
J Neurophysiol 98, 929-938
 |  Abstract »  |  Full Text »  |  PDF »

Cannabinoids ameliorate cerebral dysfunction following liver failure via AMP-activated protein kinase.

Y. Dagon, Y. Avraham, Y. Ilan, R. Mechoulam, and E. M. Berry (2007)
FASEB J 21, 2431-2441
 |  Abstract »  |  Full Text »  |  PDF »

Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase.

S. Batkai, M. Rajesh, P. Mukhopadhyay, G. Hasko, L. Liaudet, B. F. Cravatt, A. Csiszar, Z. Ungvari, and P. Pacher (2007)
Am J Physiol Heart Circ Physiol 293, H909-H918
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of the Endocannabinoid System in Retinal Damage after High Intraocular Pressure-Induced Ischemia in Rats.

C. Nucci, V. Gasperi, R. Tartaglione, A. Cerulli, A. Terrinoni, M. Bari, C. De Simone, A. F. Agro, L. A. Morrone, M. T. Corasaniti, et al. (2007)
Invest. Ophthalmol. Vis. Sci. 48, 2997-3004
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The Fatty Acid Amide Hydrolase Inhibitor URB597 (Cyclohexylcarbamic Acid 3'-Carbamoylbiphenyl-3-yl Ester) Reduces Neuropathic Pain after Oral Administration in Mice.

R. Russo, J. LoVerme, G. La Rana, T. R. Compton, J. Parrott, A. Duranti, A. Tontini, M. Mor, G. Tarzia, A. Calignano, et al. (2007)
J. Pharmacol. Exp. Ther. 322, 236-242
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Miscibility and Phase Behavior of N-Acylethanolamine/Diacylphosphatidylethanolamine Binary Mixtures of Matched Acyl Chainlengths (n = 14, 16).

R. K. Kamlekar, S. Satyanarayana, D. Marsh, and M. J. Swamy (2007)
Biophys. J. 92, 3968-3977
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Anandamide Metabolism by Human Liver and Kidney Microsomal Cytochrome P450 Enzymes to Form Hydroxyeicosatetraenoic and Epoxyeicosatrienoic Acid Ethanolamides.

N. T. Snider, A. M. Kornilov, U. M. Kent, and P. F. Hollenberg (2007)
J. Pharmacol. Exp. Ther. 321, 590-597
 |  Abstract »  |  Full Text »  |  PDF »

Endocannabinoid Regulates Blood Pressure via Activation of the Transient Receptor Potential Vanilloid Type 1 in Wistar Rats Fed a High-Salt Diet.

Y. Wang, N. E. Kaminski, and D. H. Wang (2007)
J. Pharmacol. Exp. Ther. 321, 763-769
 |  Abstract »  |  Full Text »  |  PDF »

Depolarization-induced Rapid Generation of 2-Arachidonoylglycerol, an Endogenous Cannabinoid Receptor Ligand, in Rat Brain Synaptosomes.

S. Oka, S. Arai, K. Waku, A. Tokumura, and T. Sugiura (2007)
J. Biochem. 141, 687-697
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Opposing Actions of Endocannabinoids on Cholangiocarcinoma Growth: RECRUITMENT OF Fas AND Fas LIGAND TO LIPID RAFTS.

S. DeMorrow, S. Glaser, H. Francis, J. Venter, B. Vaculin, S. Vaculin, and G. Alpini (2007)
J. Biol. Chem. 282, 13098-13113
 |  Abstract »  |  Full Text »  |  PDF »

Endocannabinoids and Synaptic Function in the CNS.

Y. Hashimotodani, T. Ohno-Shosaku, and M. Kano (2007)
Neuroscientist 13, 127-137
 |  Abstract »  |  PDF »

The Role of Diacylglycerol Lipase in Constitutive and Angiotensin AT1 Receptor-stimulated Cannabinoid CB1 Receptor Activity.

G. Turu, A. Simon, P. Gyombolai, L. Szidonya, G. Bagdy, Z. Lenkei, and L. Hunyady (2007)
J. Biol. Chem. 282, 7753-7757
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Discovery and Characterization of a Ca2+-independent Phosphatidylethanolamine N-Acyltransferase Generating the Anandamide Precursor and Its Congeners.

X.-H. Jin, Y. Okamoto, J. Morishita, K. Tsuboi, T. Tonai, and N. Ueda (2007)
J. Biol. Chem. 282, 3614-3623
 |  Abstract »  |  Full Text »  |  PDF »

Oxyhomologation of the Amide Bond Potentiates Neuroprotective Effects of the Endolipid N-Palmitoylethanolamine.

G. Lombardi, G. Miglio, F. Varsaldi, A. Minassi, and G. Appendino (2007)
J. Pharmacol. Exp. Ther. 320, 599-606
 |  Abstract »  |  Full Text »  |  PDF »

Chemical Determinants Involved in Anandamide-induced Inhibition of T-type Calcium Channels.

J. Chemin, J. Nargeot, and P. Lory (2007)
J. Biol. Chem. 282, 2314-2323
 |  Abstract »  |  Full Text »  |  PDF »

Immunocytochemical Distribution of the Cannabinoid CB1 Receptor in the Primate Neocortex: A Regional and Laminar Analysis.

S. M. Eggan and D. A. Lewis (2007)
Cereb Cortex 17, 175-191
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of the Cannabinoid CB2 Receptor and Its Endogenous Ligand 2-Arachidonoylglycerol in Oxazolone-Induced Contact Dermatitis in Mice.

S. Oka, J. Wakui, S. Ikeda, S. Yanagimoto, S. Kishimoto, M. Gokoh, M. Nasui, and T. Sugiura (2006)
J. Immunol. 177, 8796-8805
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Cannabinoid Agonists and Apparent pA2 Analysis of Cannabinoid Antagonists in Rhesus Monkeys Discriminating {Delta}9-Tetrahydrocannabinol.

L. R. McMahon (2006)
J. Pharmacol. Exp. Ther. 319, 1211-1218
 |  Abstract »  |  Full Text »  |  PDF »

A Second Fatty Acid Amide Hydrolase with Variable Distribution among Placental Mammals.

B. Q. Wei, T. S. Mikkelsen, M. K. McKinney, E. S. Lander, and B. F. Cravatt (2006)
J. Biol. Chem. 281, 36569-36578
 |  Abstract »  |  Full Text »  |  PDF »

Cannabinoid receptors as novel targets for the treatment of melanoma.

C. Blazquez, A. Carracedo, L. Barrado, P. J. Real, J. L. Fernandez-Luna, G. Velasco, M. Malumbres, and M. Guzman (2006)
FASEB J 20, 2633-2635
 |  Abstract »  |  Full Text »  |  PDF »

Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol.

B. Szabo, M. J. Urbanski, T. Bisogno, V. D. Marzo, A. Mendiguren, W. U. Baer, and I. Freiman (2006)
J. Physiol. 577, 263-280
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for Specificity in Lipid-Rhodopsin Interactions.

O. Soubias, W. E. Teague, and K. Gawrisch (2006)
J. Biol. Chem. 281, 33233-33241
 |  Abstract »  |  Full Text »  |  PDF »

Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation.

J. Palazuelos, T. Aguado, A. Egia, R. Mechoulam, M. Guzman, and I. Galve-Roperh (2006)
FASEB J 20, 2405-2407
 |  Abstract »  |  Full Text »  |  PDF »

Lipid Signaling and Synaptic Plasticity.

N. Sang and C. Chen (2006)
Neuroscientist 12, 425-434
 |  Abstract »  |  PDF »

Neuronal control of skin function: the skin as a neuroimmunoendocrine organ..

D. Roosterman, T. Goerge, S. W. Schneider, N. W. Bunnett, and M. Steinhoff (2006)
Physiol Rev 86, 1309-1379
 |  Abstract »  |  Full Text »  |  PDF »

Endocannabinoid Biosynthesis Proceeding through Glycerophospho-N-acyl Ethanolamine and a Role for {alpha}/beta-Hydrolase 4 in This Pathway.

G. M. Simon and B. F. Cravatt (2006)
J. Biol. Chem. 281, 26465-26472
 |  Abstract »  |  Full Text »  |  PDF »

Cannabinoids Modulate the P-Type High-Voltage-Activated Calcium Currents in Purkinje Neurons.

A. Fisyunov, V. Tsintsadze, R. Min, N. Burnashev, and N. Lozovaya (2006)
J Neurophysiol 96, 1267-1277
 |  Abstract »  |  Full Text »  |  PDF »

The Endocannabinoid System as an Emerging Target of Pharmacotherapy.

P. Pacher, S. Batkai, and G. Kunos (2006)
Pharmacol. Rev. 58, 389-462
 |  Abstract »  |  Full Text »  |  PDF »

Cannabinoid-1 Receptor Antagonist, Rimonabant, for Management of Obesity and Related Risks.

K. M. Gadde and D. B. Allison (2006)
Circulation 114, 974-984
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Manipulation of Arabidopsis fatty acid amide hydrolase expression modifies plant growth and sensitivity to N-acylethanolamines.

Y.-S. Wang, R. Shrestha, A. Kilaru, W. Wiant, B. J. Venables, K. D. Chapman, and E. B. Blancaflor (2006)
PNAS 103, 12197-12202
 |  Abstract »  |  Full Text »  |  PDF »

Jekyll and Hyde: Two Faces of Cannabinoid Signaling in Male and Female Fertility.

H. Wang, S. K. Dey, and M. Maccarrone (2006)
Endocr. Rev. 27, 427-448
 |  Abstract »  |  Full Text »  |  PDF »

High-Throughput Screening for the Discovery of Inhibitors of Fatty Acid Amide Hydrolase Using a Microsome-Based Fluorescent Assay.

Y. Wang, F. Ramirez, G. Krishnamurthy, A. Gilbert, N. Kadakia, J. Xu, G. Kalgaonkar, M. K. Ramarao, W. Edris, K. E. Rogers, et al. (2006)
J Biomol Screen 11, 519-527
 |  Abstract »  |  PDF »

Sex and hormonal cycle differences in rat brain levels of pain-related cannabimimetic lipid mediators.

H. B. Bradshaw, N. Rimmerman, J. F. Krey, and J. M. Walker (2006)
Am J Physiol Regulatory Integrative Comp Physiol 291, R349-R358
 |  Abstract »  |  Full Text »  |  PDF »

Molecular packing and intermolecular interactions in two structural polymorphs of N-palmitoylethanolamine, a type 2 cannabinoid receptor agonist.

R. K. Kamlekar and M. J. Swamy (2006)
J. Lipid Res. 47, 1424-1433
 |  Abstract »  |  Full Text »  |  PDF »

Cannabinoids Induce Apoptosis of Pancreatic Tumor Cells via Endoplasmic Reticulum Stress-Related Genes..

A. Carracedo, M. Gironella, M. Lorente, S. Garcia, M. Guzman, G. Velasco, and J. L. Iovanna (2006)
Cancer Res. 66, 6748-6755
 |  Abstract »  |  Full Text »  |  PDF »

Endocannabinoid System in Frog and Rodent Testis: Type-1 Cannabinoid Receptor and Fatty Acid Amide Hydrolase Activity in Male Germ Cells.

G. Cobellis, G. Cacciola, D. Scarpa, R. Meccariello, R. Chianese, M. F. Franzoni, K. Mackie, R. Pierantoni, and S. Fasano (2006)
Biol Reprod 75, 82-89
 |  Abstract »  |  Full Text »  |  PDF »

Cannabinoids Biology: The Search for New Therapeutic Targets.

C. C. Felder, A. K. Dickason-Chesterfield, and S. A. Moore (2006)
Mol. Interv. 6, 149-161
 |  Abstract »  |  Full Text »  |  PDF »

Non-targeted profiling of lipids during kainate-induced neuronal injury.

X. L. Guan, X. He, W.-Y. Ong, W. K. Yeo, G. Shui, and M. R. Wenk (2006)
FASEB J 20, 1152-1161
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and Status Epilepticus.

R. E. Blair, L. S. Deshpande, S. Sombati, K. W. Falenski, B. R. Martin, and R. J. DeLorenzo (2006)
J. Pharmacol. Exp. Ther. 317, 1072-1078
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Composition of the Endocannabinoid System at Glutamatergic Synapses.

I. Katona, G. M. Urban, M. Wallace, C. Ledent, K.-M. Jung, D. Piomelli, K. Mackie, and T. F. Freund (2006)
J. Neurosci. 26, 5628-5637
 |  Abstract »  |  Full Text »  |  PDF »

Functional Analysis of the Purified Anandamide-generating Phospholipase D as a Member of the Metallo-beta-lactamase Family.

J. Wang, Y. Okamoto, J. Morishita, K. Tsuboi, A. Miyatake, and N. Ueda (2006)
J. Biol. Chem. 281, 12325-12335
 |  Abstract »  |  Full Text »  |  PDF »

Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor..

T. Yoshida, M. Fukaya, M. Uchigashima, E. Miura, H. Kamiya, M. Kano, and M. Watanabe (2006)
J. Neurosci. 26, 4740-4751
 |  Abstract »  |  Full Text »  |  PDF »

Multiple sclerosis may disrupt endocannabinoid brain protection mechanism.

E. Shohami and R. Mechoulam (2006)
PNAS 103, 6087-6088
 |  Full Text »  |  PDF »

Fatty Acid Amide Hydrolase Determines Anandamide-induced Cell Death in the Liver.

S. V. Siegmund, E. Seki, Y. Osawa, H. Uchinami, B. F. Cravatt, and R. F. Schwabe (2006)
J. Biol. Chem. 281, 10431-10438
 |  Abstract »  |  Full Text »  |  PDF »

Anandamide Uptake Is Consistent with Rate-limited Diffusion and Is Regulated by the Degree of Its Hydrolysis by Fatty Acid Amide Hydrolase.

M. Kaczocha, A. Hermann, S. T. Glaser, I. N. Bojesen, and D. G. Deutsch (2006)
J. Biol. Chem. 281, 9066-9075
 |  Abstract »  |  Full Text »  |  PDF »

Further Characterization of the Time-Dependent Vascular Effects of {Delta}9-Tetrahydrocannabinol.

S. E. O'Sullivan, D. A. Kendall, and M. D. Randall (2006)
J. Pharmacol. Exp. Ther. 317, 428-438
 |  Abstract »  |  Full Text »  |  PDF »

Effect of an unstirred layer on the membrane permeability of anandamide.

I. N. Bojesen and H. S. Hansen (2006)
J. Lipid Res. 47, 561-570
 |  Abstract »  |  Full Text »  |  PDF »

Elevation of Endocannabinoid Levels in the Ventrolateral Periaqueductal Grey through Inhibition of Fatty Acid Amide Hydrolase Affects Descending Nociceptive Pathways via Both Cannabinoid Receptor Type 1 and Transient Receptor Potential Vanilloid Type-1 Receptors.

S. Maione, T. Bisogno, V. de Novellis, E. Palazzo, L. Cristino, M. Valenti, S. Petrosino, V. Guglielmotti, F. Rossi, and V. D. Marzo (2006)
J. Pharmacol. Exp. Ther. 316, 969-982
 |  Abstract »  |  Full Text »  |  PDF »

Ex Vivo Imaging of Fatty Acid Amide Hydrolase Activity and Its Inhibition in the Mouse Brain.

S. T. Glaser, S. J. Gatley, and A. N. Gifford (2006)
J. Pharmacol. Exp. Ther. 316, 1088-1097
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation-Dependent Desensitization by Anandamide of Vanilloid Receptor-1 (TRPV1) Function in Rat Skeletal Muscle Arterioles and in Chinese Hamster Ovary Cells Expressing TRPV1.

E. Lizanecz, Z. Bagi, E. T. Pasztor, Z. Papp, I. Edes, N. Kedei, P. M. Blumberg, and A. Toth (2006)
Mol. Pharmacol. 69, 1015-1023
 |  Abstract »  |  Full Text »  |  PDF »

N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties.

G. Milman, Y. Maor, S. Abu-Lafi, M. Horowitz, R. Gallily, S. Batkai, F.-M. Mo, L. Offertaler, P. Pacher, G. Kunos, et al. (2006)
PNAS 103, 2428-2433
 |  Abstract »  |  Full Text »  |  PDF »

The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance.

U. Pagotto, G. Marsicano, D. Cota, B. Lutz, and R. Pasquali (2006)
Endocr. Rev. 27, 73-100
 |  Abstract »  |  Full Text »  |  PDF »

Cannabinoid Analgesia as a Potential New Therapeutic Option in the Treatment of Chronic Pain.

T. L Burns and J. R Ineck (2006)
Ann. Pharmacother. 40, 251-260