Science 18 December 1992: Vol. 258. no. 5090, pp. 1952 - 1955 DOI: 10.1126/science.1335167

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Articles

Evolution of vertebrate opioid receptors.

S. Dreborg, G. Sundstrom, T. A. Larsson, and D. Larhammar (2008)
PNAS 105, 15487-15492
 |  Abstract »  |  Full Text »  |  PDF »

Endogenous opioids: role in prostaglandin-dependent and -independent fever.

D. Fraga, R. R. Machado, L. C. Fernandes, G. E. P. Souza, and A. R. Zampronio (2008)
Am J Physiol Regulatory Integrative Comp Physiol 294, R411-R420
 |  Abstract »  |  Full Text »  |  PDF »

Central serotonergic neurons are differentially required for opioid analgesia but not for morphine tolerance or morphine reward.

Z.-Q. Zhao, Y.-J. Gao, Y.-G. Sun, C.-S. Zhao, R. W. Gereau IV, and Z.-F. Chen (2007)
PNAS 104, 14519-14524
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of a new duplicate {delta}-opioid receptor from zebrafish.

N. Pinal-Seoane, I. R. Martin, V. Gonzalez-Nunez, E. M. F. de Velasco, F. A. Alvarez, R. G. Sarmiento, and R. E Rodriguez (2006)
J. Mol. Endocrinol. 37, 391-403
 |  Abstract »  |  Full Text »  |  PDF »

The monosialosyl ganglioside GM-1 reduces the vagolytic efficacy of {delta}2-opioid receptor stimulation.

S. Davis, S. H. Deo, M. Barlow, D. Yoshishige, M. Farias, and J. L. Caffrey (2006)
Am J Physiol Heart Circ Physiol 291, H2318-H2326
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Opioid Receptor Internalization and {beta}-Arrestins in the Development of Opioid Tolerance.

Z. Zuo (2005)
Anesth. Analg. 101, 728-734
 |  Abstract »  |  Full Text »  |  PDF »

Interactions between {delta} and {micro} Opioid Agonists in Assays of Schedule-Controlled Responding, Thermal Nociception, Drug Self-Administration, and Drug versus Food Choice in Rhesus Monkeys: Studies with SNC80 [(+)-4-[({alpha}R)-{alpha}-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] and Heroin.

G. W. Stevenson, J. E. Folk, K. C. Rice, and S. S. Negus (2005)
J. Pharmacol. Exp. Ther. 314, 221-231
 |  Abstract »  |  Full Text »  |  PDF »

Antagonist Efficacy in MORS196L Mutant Is Affected by the Interaction between Transmembrane Domains of the Opioid Receptor.

P. A. Claude-Geppert, J. Liu, J. Solberg, L. J. Erickson-Herbrandson, H. H. Loh, and P.-Y. Law (2005)
J. Pharmacol. Exp. Ther. 313, 216-226
 |  Abstract »  |  Full Text »  |  PDF »

Pharmacogenetics and Human Molecular Genetics of Opiate and Cocaine Addictions and Their Treatments.

M. J. Kreek, G. Bart, C. Lilly, K. S. Laforge, and D. A. Nielsen (2005)
Pharmacol. Rev. 57, 1-26
 |  Abstract »  |  Full Text »  |  PDF »

Type I PDZ Ligands Are Sufficient to Promote Rapid Recycling of G Protein-coupled Receptors Independent of Binding to N-Ethylmaleimide-sensitive Factor.

R. M. Gage, E. A. Matveeva, S. W. Whiteheart, and M. von Zastrow (2005)
J. Biol. Chem. 280, 3305-3313
 |  Abstract »  |  Full Text »  |  PDF »

The Composition of the {beta}-2 Adrenergic Receptor Oligomer Affects Its Membrane Trafficking after Ligand-Induced Endocytosis.

T. T. Cao, A. Brelot, and M. von Zastrow (2005)
Mol. Pharmacol. 67, 288-297
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Novel Endocytic Recycling Signal in the D1 Dopamine Receptor.

G. A. Vargas and M. von Zastrow (2004)
J. Biol. Chem. 279, 37461-37469
 |  Abstract »  |  Full Text »  |  PDF »

Cross-talk of opioid peptide receptor and {beta}-adrenergic receptor signalling in the heart.

S. Pepe, O. W.V van den Brink, E. G Lakatta, and R.-P. Xiao (2004)
Cardiovasc Res 63, 414-422
 |  Abstract »  |  Full Text »  |  PDF »

Modeling and simulation of the human {delta} opioid receptor.

M. Aburi and P. E. Smith (2004)
Protein Sci. 13, 1997-2008
 |  Abstract »  |  Full Text »  |  PDF »

FE200041 (D-Phe-D-Phe-D-Nle-D-Arg-NH2): A Peripheral Efficacious {kappa} Opioid Agonist with Unprecedented Selectivity.

T. W. Vanderah, C. D. Schteingart, J. Trojnar, J.-L. Junien, J. Lai, and P. J.-M. Riviere (2004)
J. Pharmacol. Exp. Ther. 310, 326-333
 |  Abstract »  |  Full Text »  |  PDF »

Proinflammatory Chemokines, Such as C-C Chemokine Ligand 3, Desensitize {micro}-Opioid Receptors on Dorsal Root Ganglia Neurons.

N. Zhang, T. J. Rogers, M. Caterina, and J. J. Oppenheim (2004)
J. Immunol. 173, 594-599
 |  Abstract »  |  Full Text »  |  PDF »

Morphine-Induced Changes in {delta} Opioid Receptor Trafficking Are Linked to Somatosensory Processing in the Rat Spinal Cord.

A. Morinville, C. M. Cahill, H. Aibak, V. V. Rymar, A. Pradhan, C. Hoffert, F. Mennicken, T. Stroh, A. F. Sadikot, D. O'Donnell, et al. (2004)
J. Neurosci. 24, 5549-5559
 |  Abstract »  |  Full Text »  |  PDF »

Exploring Deltorphin II Binding to the Third Extracellular Loop of the {delta}-Opioid Receptor.

I. Fadhil, R. Schmidt, C. Walpole, and K. A. Carpenter (2004)
J. Biol. Chem. 279, 21069-21077
 |  Abstract »  |  Full Text »  |  PDF »

Cloning and Characterization of Xen-dorphin Prohormone from Xenopus laevis: A NEW OPIOID-LIKE PROHORMONE DISTINCT FROM PROENKEPHALIN AND PRODYNORPHIN.

P. Pattee, A.-E. Ilie, S. Benyhe, G. Toth, A. Borsodi, and S. R. Nagalla (2003)
J. Biol. Chem. 278, 53098-53104
 |  Abstract »  |  Full Text »  |  PDF »

Opioid Interactions in Rhesus Monkeys: Effects of {delta} + {micro} and {delta} + {kappa} Agonists on Schedule-Controlled Responding and Thermal Nociception.

G. W. Stevenson, J. E. Folk, D. C. Linsenmayer, K. C. Rice, and S. S. Negus (2003)
J. Pharmacol. Exp. Ther. 307, 1054-1064
 |  Abstract »  |  Full Text »  |  PDF »

Selective inactivation of CCR5 and decreased infectivity of R5 HIV-1 strains mediated by opioid-induced heterologous desensitization.

I. Szabo, M. A. Wetzel, N. Zhang, A. D. Steele, D. E. Kaminsky, C. Chen, L.-Y. Liu-Chen, F. Bednar, E. E. Henderson, O. M. Z. Howard, et al. (2003)
J. Leukoc. Biol. 74, 1074-1082
 |  Abstract »  |  Full Text »

A Novel Endocytic Recycling Signal That Distinguishes the Membrane Trafficking of Naturally Occurring Opioid Receptors.

M. Tanowitz and M. von Zastrow (2003)
J. Biol. Chem. 278, 45978-45986
 |  Abstract »  |  Full Text »  |  PDF »

The Expression of {delta}- and {kappa}-Opioid Receptor Is Enhanced during Intestinal Inflammation in Mice.

O. Pol, J. R. Palacio, and M. M. Puig (2003)
J. Pharmacol. Exp. Ther. 306, 455-462
 |  Abstract »  |  Full Text »  |  PDF »

Morphine and Endomorphins Differentially Regulate {micro}-Opioid Receptor mRNA in SHSY-5Y Human Neuroblastoma Cells.

X. Yu, X. Mao, A. D. Blake, W. X. Li, and S. L. Chang (2003)
J. Pharmacol. Exp. Ther. 306, 447-454
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of {delta}-Opioid Receptor Trafficking via {micro}-Opioid Receptor Stimulation: Evidence from {micro}-Opioid Receptor Knock-Out Mice.

A. Morinville, C. M. Cahill, M. J. Esdaile, H. Aibak, B. Collier, B. L. Kieffer, and A. Beaudet (2003)
J. Neurosci. 23, 4888-4898
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of sympathetic efferents but not capsaicin-sensitive afferents in nociceptin-mediated dual control of rat synovial blood flow.

J. J. McDougall (2003)
Am J Physiol Regulatory Integrative Comp Physiol 284, R1477-R1485
 |  Abstract »  |  Full Text »  |  PDF »

Cardiac enkephalins interrupt vagal bradycardia via delta 2-opioid receptors in sinoatrial node.

M. Farias III, K. E. Jackson, D. Yoshishige, and J. L. Caffrey (2003)
Am J Physiol Heart Circ Physiol 284, H1693-H1701
 |  Abstract »  |  Full Text »  |  PDF »

Neurotrophin-Regulated Sorting of Opioid Receptors in the Biosynthetic Pathway of Neurosecretory Cells.

K.-A. Kim and M. von Zastrow (2003)
J. Neurosci. 23, 2075-2085
 |  Abstract »  |  Full Text »  |  PDF »

Ubiquitination-independent Trafficking of G Protein-coupled Receptors to Lysosomes.

M. Tanowitz and M. von Zastrow (2002)
J. Biol. Chem. 277, 50219-50222
 |  Abstract »  |  Full Text »  |  PDF »

Spinal Pretreatment with Antisense Oligodeoxynucleotides against Exon-1, -4, or -8 of {micro}-Opioid Receptor Clone Leads to Differential Loss of Spinal Endomorphin-1-and Endomorphin-2-Induced Antinociception in the Mouse.

H.-e. Wu, H. Mizoguchi, M. Terashvili, R. J. Leitermann, K.-c. Hung, J. M. Fujimoto, and L. F. Tseng (2002)
J. Pharmacol. Exp. Ther. 303, 867-873
 |  Abstract »  |  Full Text »  |  PDF »

Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain.

I. Szabo, X.-H. Chen, L. Xin, M. W. Adler, O. M. Z. Howard, J. J. Oppenheim, and T. J. Rogers (2002)
PNAS 99, 10276-10281
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Postendocytic Sorting of G Protein-Coupled Receptors.

J. L. Whistler, J. Enquist, A. Marley, J. Fong, F. Gladher, P. Tsuruda, S. R. Murray, and M. von Zastrow (2002)
Science 297, 615-620
 |  Abstract »  |  Full Text »  |  PDF »

Prolonged Morphine Treatment Targets {delta} Opioid Receptors to Neuronal Plasma Membranes and Enhances {delta}-Mediated Antinociception.

C. M. Cahill, A. Morinville, M.-C. Lee, J.-P. Vincent, B. Collier, and A. Beaudet (2001)
J. Neurosci. 21, 7598-7607
 |  Abstract »  |  Full Text »  |  PDF »

Morphine Inhibits Mucosal Antibody Responses and TGF-{beta} mRNA in Gut-Associated Lymphoid Tissue Following Oral Cholera Toxin in Mice.

X. Peng, J. J. Cebra, M. W. Adler, J. J. Meissler Jr., A. Cowan, P. Feng, and T. K. Eisenstein (2001)
J. Immunol. 167, 3677-3681
 |  Abstract »  |  Full Text »  |  PDF »

The Molecular and Behavioral Pharmacology of the Orphanin FQ/Nociceptin Peptide and Receptor Family.

J. S. Mogil and G. W. Pasternak (2001)
Pharmacol. Rev. 53, 381-415
 |  Abstract »  |  Full Text »  |  PDF »

delta -Opioid Receptor Gene: Effect of Sp1 Factor on Transcriptional Regulation in Vivo.

D. Smirnov, H.-J. Im, and H. H. Loh (2001)
Mol. Pharmacol. 60, 331-340
 |  Abstract »  |  Full Text »  |  PDF »

Immunofluorescence Detection of {{delta}} Opioid Receptors (DOR) on Human Peripheral Blood CD4+ T Cells and DOR-Dependent Suppression of HIV-1 Expression.

B. M. Sharp, K. McAllen, G. Gekker, N. A. Shahabi, and P. K. Peterson (2001)
J. Immunol. 167, 1097-1102
 |  Abstract »  |  Full Text »  |  PDF »

Preferential Cytoplasmic Localization of {delta}-Opioid Receptors in Rat Striatal Patches: Comparison with Plasmalemmal {micro}-Opioid Receptors.

H. Wang and V. M. Pickel (2001)
J. Neurosci. 21, 3242-3250
 |  Abstract »  |  Full Text »  |  PDF »

Comparison of Pharmacological Activities of Buprenorphine and Norbuprenorphine: Norbuprenorphine Is a Potent Opioid Agonist.

P. Huang, G. B. Kehner, A. Cowan, and L.-Y. Liu-Chen (2001)
J. Pharmacol. Exp. Ther. 297, 688-695
 |  Abstract »  |  Full Text »

Supraspinal Antinociceptive Response to [D-Pen2,5]-Enkephalin (DPDPE) Is Pharmacologically Distinct from That to Other delta -Agonists in the Rat.

G. L. Fraser, A. A. Pradhan, P. B. S. Clarke, and C. Wahlestedt (2000)
J. Pharmacol. Exp. Ther. 295, 1135-1141
 |  Abstract »  |  Full Text »

{micro}-Opioid Induction of Monocyte Chemoattractant Protein-1, RANTES, and IFN-{gamma}-Inducible Protein-10 Expression in Human Peripheral Blood Mononuclear Cells.

M. A. Wetzel, A. D. Steele, T. K. Eisenstein, M. W. Adler, E. E. Henderson, and T. J. Rogers (2000)
J. Immunol. 165, 6519-6524
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of Agonist-Induced Down-Regulation of the Human kappa -Opioid Receptor: Internalization Is Required for Down-Regulation.

J.-G. Li, J. L. Benovic, and L.-Y. Liu-Chen (2000)
Mol. Pharmacol. 58, 795-801
 |  Abstract »  |  Full Text »

Prolactin: Structure, Function, and Regulation of Secretion.

M. E. Freeman, B. Kanyicska, A. Lerant, and G. Nagy (2000)
Physiol Rev 80, 1523-1631
 |  Abstract »  |  Full Text »  |  PDF »

Detection and Function of Opioid Receptors on Cells from the Immune System.

J. M. Bidlack (2000)
Clin. Vaccine Immunol. 7, 719-723
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Microinjection of Nociceptin (Orphanin FQ) into Nucleus Tractus Solitarii Elevates Blood Pressure and Heart Rate in Both Anesthetized and Conscious Rats.

L. Mao and J. Q. Wang (2000)
J. Pharmacol. Exp. Ther. 294, 255-262
 |  Abstract »  |  Full Text »

Chronic Heroin Self-Administration Desensitizes {micro} Opioid Receptor-Activated G-Proteins in Specific Regions of Rat Brain.

L. J. Sim-Selley, D. E. Selley, L. J. Vogt, S. R. Childers, and T. J. Martin (2000)
J. Neurosci. 20, 4555-4562
 |  Abstract »  |  Full Text »  |  PDF »

Type-specific Sorting of G Protein-coupled Receptors after Endocytosis.

P. I. Tsao and M. von Zastrow (2000)
J. Biol. Chem. 275, 11130-11140
 |  Abstract »  |  Full Text »  |  PDF »

Selected Cysteine Residues in Transmembrane Domains of {micro}-Opioid Receptor Are Critical for Effects of Sulfhydryl Reagents.

H. B. Deng, W. Guang, and J. B. Wang (2000)
J. Pharmacol. Exp. Ther. 293, 113-120
 |  Abstract »  |  Full Text »

Internalization and Recycling of delta -Opioid Receptor Are Dependent on a Phosphorylation-Dephosphorylation Mechanism.

A. Hasbi, S. Allouche, F. Sichel, L. Stanasila, D. Massotte, G. Landemore, J. Polastron, and P. Jauzac (2000)
J. Pharmacol. Exp. Ther. 293, 237-247
 |  Abstract »  |  Full Text »

Antisense Inhibition of delta -Opioid Receptor Gene Function In Vivo by Peptide Nucleic Acids.

G. L. Fraser, J. Holmgren, P. B. S. Clarke, and C. Wahlestedt (2000)
Mol. Pharmacol. 57, 725-731
 |  Abstract »  |  Full Text »

G Protein beta gamma Subunits Induce Stress Fiber Formation and Focal Adhesion Assembly in a Rho-dependent Manner in HeLa Cells.

H. Ueda, H. Itoh, J. Yamauchi, R. Morishita, Y. Kaziro, K. Kato, and T. Asano (2000)
J. Biol. Chem. 275, 2098-2102
 |  Abstract »  |  Full Text »  |  PDF »

3D modeling, ligand binding and activation studies of the cloned mouse {delta}, {micro} and {kappa} opioid receptors.

M. Filizola, L. Laakkonen, and G. H. loew (1999)
Protein Eng. Des. Sel. 12, 927-942
 |  Abstract »  |  Full Text »  |  PDF »

delta -Opioid-Induced Liberation of Gbeta gamma Mobilizes Ca2+ Stores in NG108-15 Cells.

S. H. Yoon, T.-M. Lo, H. H. Loh, and S. A. Thayer (1999)
Mol. Pharmacol. 56, 902-908
 |  Abstract »  |  Full Text »

Dose-Related Opposite Modulation by Nociceptin/Orphanin FQ of Substance P Nociception in the Nociceptors and Spinal Cord.

M. Inoue, I. Shimohira, A. Yoshida, A. Zimmer, H. Takeshima, T. Sakurada, and H. Ueda (1999)
J. Pharmacol. Exp. Ther. 291, 308-313
 |  Abstract »  |  Full Text »

Physiological Regulation of G Protein-Linked Signaling.

A. J. Morris and C. C. Malbon (1999)
Physiol Rev 79, 1373-1430
 |  Abstract »  |  Full Text »  |  PDF »

The delta -Opioid Receptor: Molecular Pharmacology, Signal Transduction, and the Determination of Drug Efficacy.

R. M. Quock, T. H. Burkey, E. Varga, Y. Hosohata, K. Hosohata, S. M. Cowell, C. A. Slate, F. J. Ehlert, W. R. Roeske, and H. I. Yamamura (1999)
Pharmacol. Rev. 51, 503-532
 |  Abstract »  |  Full Text »  |  PDF »

Genetic alteration of phospholipase C beta 3 expression modulates behavioral and cellular responses to {micro} opioids.

W. Xie, G. M. Samoriski, J. P. McLaughlin, V. A. Romoser, A. Smrcka, P. M. Hinkle, J. M. Bidlack, R. A. Gross, H. Jiang, and D. Wu (1999)
PNAS 96, 10385-10390
 |  Abstract »  |  Full Text »  |  PDF »

Calmodulin Binding to G Protein-coupling Domain of Opioid Receptors.

D. Wang, W. Sadee, and J. M. Quillan (1999)
J. Biol. Chem. 274, 22081-22088
 |  Abstract »  |  Full Text »  |  PDF »

Opioids, Reward and Addiction: An Encounter of Biology, Psychology, and Medicine.

J. M. van Ree, M. A. F. M. Gerrits, and L. J. M. J. Vanderschuren (1999)
Pharmacol. Rev. 51, 341-396
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Opioid Receptor Activities.

P.-Y. Law and H. H. Loh (1999)
J. Pharmacol. Exp. Ther. 289, 607-624
 |  Abstract »  |  Full Text »

Peripheral and central actions of orphanin FQ (nociceptin) on murine colon.

M. A. Osinski, P. Bass, and E. A. Gaumnitz (1999)
Am J Physiol Gastrointest Liver Physiol 276, G125-G131
 |  Abstract »  |  Full Text »  |  PDF »

Delta Opioid Receptor Down-Regulation Is Independent of Functional G Protein yet Is Dependent on Agonist Efficacy.

A. E. Remmers, M. J. Clark, X. Y. Liu, and F. Medzihradsky (1998)
J. Pharmacol. Exp. Ther. 287, 625-632
 |  Abstract »  |  Full Text »

Pertussis toxin abolishes the cardioprotective effect of ischemic preconditioning in intact rat heart.

J. E. J. Schultz, A. K. Hsu, J. T. Barbieri, P.-L. Li, and G. J. Gross (1998)
Am J Physiol Heart Circ Physiol 275, H495-H500
 |  Abstract »  |  Full Text »  |  PDF »

Differential Interactions of the C terminus and the Cytoplasmic I-II Loop of Neuronal Ca2+ Channels with G-protein alpha  and beta gamma Subunits. I. MOLECULAR DETERMINATION.

T. Furukawa, T. Nukada, Y. Mori, M. Wakamori, Y. Fujita, H. Ishida, K. Fukuda, S. Kato, and M. Yoshii (1998)
J. Biol. Chem. 273, 17585-17594
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Carboxyl-terminal Splicing of the Rat µ Opioid Receptor Modulates Agonist-mediated Internalization and Receptor Resensitization.

T. Koch, S. Schulz, H. Schroder, R. Wolf, E. Raulf, and V. Hollt (1998)
J. Biol. Chem. 273, 13652-13657
 |  Abstract »  |  Full Text »  |  PDF »

Delta Opioid Receptor Subtypes Activate Inositol-Signaling Pathways in the Production of Antinociception.

P. Sánchez-Blázquez and J. Garzón (1998)
J. Pharmacol. Exp. Ther. 285, 820-827
 |  Abstract »  |  Full Text »

Agonist-Induced Desensitization and Down-regulation of the Human Kappa Opioid Receptor Expressed in Chinese Hamster Ovary Cells.

J. Zhu, L.-Y. Luo, G.-F. Mao, B. Ashby, and L.-Y. Liu-Chen (1998)
J. Pharmacol. Exp. Ther. 285, 28-36
 |  Abstract »  |  Full Text »

Novel Somatostatin Analogs for the Treatment of Acromegaly and Cancer Exhibit Improved In Vivo Stability and Distribution.

T. J. Gillespie, A. Erenberg, S. Kim, J. Dong, J. E. Taylor, V. Hau, and T. P. Davis (1998)
J. Pharmacol. Exp. Ther. 285, 95-104
 |  Abstract »  |  Full Text »

Developmental Expression of the µ, kappa , and delta  Opioid Receptor mRNAs in Mouse.

Y. Zhu, M.-S. Hsu, and J. E. Pintar (1998)
J. Neurosci. 18, 2538-2549
 |  Abstract »  |  Full Text »  |  PDF »

TAN-67, a delta 1-opioid receptor agonist, reduces infarct size via activation of Gi/o proteins and KATP channels.

J. E. J. Schultz, A. K. Hsu, H. Nagase, and G. J. Gross (1998)
Am J Physiol Heart Circ Physiol 274, H909-H914
 |  Abstract »  |  Full Text »  |  PDF »

Mutagenesis of the Mouse Delta Opioid Receptor Converts (-)-Buprenorphine from a Partial Agonist to an Antagonist.

G. Bot, A. D. Blake, S. Li, and T. Reisine (1998)
J. Pharmacol. Exp. Ther. 284, 283-290
 |  Abstract »  |  Full Text »

Delta Opioid Modulation of the Binding of Guanosine-5'-O-(3-[35S]thio)triphosphate to NG108-15 Cell Membranes: Characterization of Agonist and Inverse Agonist Effects.

P. G. Szekeres and J. R. Traynor (1997)
J. Pharmacol. Exp. Ther. 283, 1276-1284
 |  Abstract »  |  Full Text »

Naloxone Activation of µ-Opioid Receptors Mutated at a Histidine Residue Lining the Opioid Binding Cavity.

C. E. Spivak, C. L. Beglan, B. K. Seidleck, L. D. Hirshbein, C. J. Blaschak, G. R. Uhl, and C. K. Surratt (1997)
Mol. Pharmacol. 52, 983-992
 |  Abstract »  |  Full Text »

Opioid Efficacy in a C6 Glioma Cell Line Stably Expressing the Delta Opioid Receptor.

M. J. Clark, P. J. Emmerson, A. Mansour, H. Akil, J. H. Woods, P. S. Portoghese, A. E. Remmers, and F. Medzihradsky (1997)
J. Pharmacol. Exp. Ther. 283, 501-510
 |  Abstract »  |  Full Text »

Dimerization of the delta  Opioid Receptor:. IMPLICATION FOR A ROLE IN RECEPTOR INTERNALIZATION.

S. Cvejic and L. A. Devi (1997)
J. Biol. Chem. 272, 26959-26964
 |  Abstract »  |  Full Text »  |  PDF »

Antisense Mapping of the MOR-1 Opioid Receptor Clone: Modulation of Hyperphagia Induced by DAMGO.

L. Leventhal, L. B. Stevens, G. C. Rossi, G. W. Pasternak, and R. J. Bodnar (1997)
J. Pharmacol. Exp. Ther. 282, 1402-1407
 |  Abstract »  |  Full Text »

Gonadal Peptides as Mediators of Development and Functional Control of the Testis: An Integrated System with Hormones and Local Environment.

L. Gnessi, A. Fabbri, and G. Spera (1997)
Endocr. Rev. 18, 541-609
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Cloned Human Kappa Opioid Receptor by Agonists Enhances [35S]GTPgamma S Binding to Membranes: Determination of Potencies and Efficacies of Ligands.

J. Zhu, L.-Y. Luo, J.-G. Li, C. Chen, and L.-Y. Liu-Chen (1997)
J. Pharmacol. Exp. Ther. 282, 676-684
 |  Abstract »  |  Full Text »

Pharmacological Characterization of Orphanin FQ/Nociceptin and its Fragments.

G. C. Rossi, L. Leventhal, E. Bolan, and G. W. Pasternak (1997)
J. Pharmacol. Exp. Ther. 282, 858-865
 |  Abstract »  |  Full Text »

Opioid Regulation of the Mouse delta -Opioid Receptor Expressed in Human Embryonic Kidney 293 Cells.

G. Bot, A. D. Blake, S. Li, and T. Reisine (1997)
Mol. Pharmacol. 52, 272-281
 |  Abstract »  |  Full Text »

Opioid receptors from a lower vertebrate (Catostomus commersoni): Sequence, pharmacology, coupling to a G-protein-gated inward-rectifying potassium channel (GIRK1), and evolution.

M. G. Darlison, F. R. Greten, R. J. Harvey, H.-J. Kreienkamp, T. Stuhmer, H. Zwiers, K. Lederis, and D. Richter (1997)
PNAS 94, 8214-8219
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The µ-Opioid Receptor Down-Regulates Differently from the delta -Opioid Receptor: Requirement of a High Affinity Receptor/G Protein Complex Formation.

S. Chakrabarti, W. Yang, P.-Y. Law, and H. H. Loh (1997)
Mol. Pharmacol. 52, 105-113
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S. F. Law and T. Reisine (1997)
J. Pharmacol. Exp. Ther. 281, 1476-1486
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Novel "Restoration of Function" Mutagenesis Strategy to Identify Amino Acids of the delta -Opioid Receptor Involved in Ligand Binding.

M.-C. Pepin, S. Y. Yue, E. Roberts, C. Wahlestedt, and P. Walker (1997)
J. Biol. Chem. 272, 9260-9267
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Antisense Mapping of MOR-1 in Rats: Distinguishing between Morphine and Morphine-6beta -glucuronide Antinociception.

G. C. Rossi, L. Leventhal, Y.-X. Pan, J. Cole, W. Su, R. J. Bodnar, and G. W. Pasternak (1997)
J. Pharmacol. Exp. Ther. 281, 109-114
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Antisense Targeting of Delta Opioid Receptors in NG 108-15 Cells: Direct Correlation between Oligodeoxynucleotide Uptake and Receptor Density.

J. Lai, T. J. Crook, A. Payne, R. M. Lynch, and F. Porreca (1997)
J. Pharmacol. Exp. Ther. 281, 589-596
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Antisense Oligodeoxynucleotides to Opioid Mu and Delta Receptors Reduced Morphine Dependence in Mice: Role of Delta-2 Opioid Receptors.

P. Sánchez-Blázquez, A. García-España, and J. Garzón (1997)
J. Pharmacol. Exp. Ther. 280, 1423-1431
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Opiate receptor knockout mice define µ receptor roles in endogenous nociceptive responses and morphine-induced analgesia.

I. Sora, N. Takahashi, M. Funada, H. Ujike, R. S. Revay, D. M. Donovan, L. L. Miner, and G. R. Uhl (1997)
PNAS 94, 1544-1549
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Delta-1 Opioid Receptor-Mediated Antinociceptive Properties of a Nonpeptidic Delta Opioid Receptor Agonist, (-)TAN-67, in the Mouse Spinal Cord.

L. F. Tseng, M. Narita, H. Mizoguchi, K. Kawai, A. Mizusuna, J. Kamei, T. Suzuki, and H. Nagase (1997)
J. Pharmacol. Exp. Ther. 280, 600-605
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{micro}-Opioid Receptor-Stimulated Guanosine-5'-O-(gamma -thio)-triphosphate Binding in Rat Thalamus and Cultured Cell Lines: Signal Transduction Mechanisms Underlying Agonist Efficacy.

D. E. Selley, L. J. Sim, R. Xiao, Q. Liu, and S. R. Childers (1997)
Mol. Pharmacol. 51, 87-96
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Agonist Activation of delta -Opioid Receptor but not {micro}-Opioid Receptor Potentiates Fetal Calf Serum or Tyrosine Kinase Receptor-Mediated Cell Proliferation in a CellLine-Specific Manner.

P. Y. Law, T. M. McGinn, K. M. Campbell, L. E. Erickson, and H.H. Loh (1997)
Mol. Pharmacol. 51, 152-160
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Sequestration of the delta Opioid Receptor. ROLE OF THE C TERMINUS IN AGONIST-MEDIATED INTERNALIZATION.

N. Trapaidze, D. E. Keith, S. Cvejic, C. J. Evans, and L. A. Devi (1996)
J. Biol. Chem.