Related Content
Search Google Scholar for:
|
|
Science 2 July 1993:
Vol. 261. no. 5117, pp. 104 - 106
DOI: 10.1126/science.8391168
|
|
Articles
Science, Vol 261, Issue 5117, 104-106
Copyright © 1993 by American Association for the Advancement of Science
Enhancement by histamine of NMDA-mediated synaptic transmission in the hippocampus
JM Bekkers
Division of Neuroscience, John Curtin School of Medical Research, Australian National Univresity, Canberra, ACT.
Histamine is a neuromodulator in the brain, and the hippocampus is one of the regions of the brain that is innervated by histaminergic neurons. When applied to cultured hippocampal neurons, histamine selectively increased by up to tenfold the amplitude of the component of synaptic transmission that was mediated by N-methyl-D-aspartate (NMDA) receptors. Spontaneous miniature synaptic currents and the current elicited by applied NMDA also were enhanced, indicating that the histamine effect was expressed primarily postsynaptically. These results suggest that histamine may modulate processes involving NMDA receptors, such as the induction of long-term potentiation.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Ras Signaling Mechanisms Underlying Impaired GluR1-Dependent Plasticity Associated with Fragile X Syndrome.
- H. Hu, Y. Qin, G. Bochorishvili, Y. Zhu, L. van Aelst, and J. J. Zhu (2008)
J. Neurosci.
28, 7847-7862
| Abstract »
| Full Text »
| PDF »
- Histamine in the Nervous System.
- H. L. Haas, O. A. Sergeeva, and O. Selbach (2008)
Physiol Rev
88, 1183-1241
| Abstract »
| Full Text »
| PDF »
- Histaminergic Neurons Protect the Developing Hippocampus from Kainic Acid-Induced Neuronal Damage in an Organotypic Coculture System.
- T.-K. Kukko-Lukjanov, S. Soini, T. Taira, K. A. Michelsen, P. Panula, and I. E. Holopainen (2006)
J. Neurosci.
26, 1088-1097
| Abstract »
| Full Text »
| PDF »
- State-dependent Ras signaling and AMPA receptor trafficking.
- Y. Qin, Y. Zhu, J. P. Baumgart, R. L. Stornetta, K. Seidenman, V. Mack, L. van Aelst, and J. J. Zhu (2005)
Genes & Dev.
19, 2000-2015
| Abstract »
| Full Text »
| PDF »
- Histamine H2-Receptor Antagonist Ranitidine Protects Against Neural Death Induced by Oxygen-Glucose Deprivation.
- C. Malagelada, X. Xifro, N. Badiola, J. Sabria, and J. Rodriguez-Alvarez (2004)
Stroke
35, 2396-2401
| Abstract »
| Full Text »
| PDF »
- Histidine-Decarboxylase Knockout Mice Show Deficient Nonreinforced Episodic Object Memory, Improved Negatively Reinforced Water-Maze Performance, and Increased Neo- and Ventro-Striatal Dopamine Turnover.
- E. Dere, M. A. De Souza-Silva, B. Topic, R. E. Spieler, H. L. Haas, and J. P. Huston (2003)
Learn. Mem.
10, 510-519
| Abstract »
| Full Text »
| PDF »
- Histamine Suppresses Non-NMDA Excitatory Synaptic Currents in Rat Supraoptic Nucleus Neurons.
- Z. Li and G. I. Hatton (2000)
J Neurophysiol
83, 2616-2625
| Abstract »
| Full Text »
| PDF »
- International Union of Pharmacology. XIII. Classification of Histamine Receptors.
- S. J. Hill, C. R. Ganellin, H. Timmerman, J. C. Schwartz, N. P. Shankley, J. M. Young, W. Schunack, R. Levi, and H. L. Haas (1997)
Pharmacol. Rev.
49, 253-278
| Abstract »
| Full Text »
| PDF »
- Theta/gamma networks with slow NMDA channels learn sequences and encode episodic memory: role of NMDA channels in recall..
- O Jensen and J E Lisman (1996)
Learn. Mem.
3, 264-278
| Abstract »
| PDF »
|
|
