Science 9 July 1993: Vol. 261. no. 5118, pp. 215 - 218 DOI: 10.1126/science.8392225

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Articles

Dioxin Causes Ventral Prostate Agenesis by Disrupting Dorsoventral Patterning in Developing Mouse Prostate.

C. M. Vezina, S. H. Allgeier, R. W. Moore, T.-M. Lin, J. C. Bemis, H. A. Hardin, T. A. Gasiewicz, and R. E. Peterson (2008)
Toxicol. Sci. 106, 488-496
 |  Abstract »  |  Full Text »  |  PDF »

A highly conserved molecular switch binds MSY-3 to regulate myogenin repression in postnatal muscle.

L. Berghella, L. De Angelis, T. De Buysscher, A. Mortazavi, S. Biressi, S. V. Forcales, D. Sirabella, G. Cossu, and B. J. Wold (2008)
Genes & Dev. 22, 2125-2138
 |  Abstract »  |  Full Text »  |  PDF »

MURC, a muscle-restricted coiled-coil protein, is involved in the regulation of skeletal myogenesis.

M. Tagawa, T. Ueyama, T. Ogata, N. Takehara, N. Nakajima, K. Isodono, S. Asada, T. Takahashi, H. Matsubara, and H. Oh (2008)
Am J Physiol Cell Physiol 295, C490-C498
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Regulation of Skeletal Muscle Sarcomere Integrity and Postnatal Muscle Function by Mef2c.

M. J. Potthoff, M. A. Arnold, J. McAnally, J. A. Richardson, R. Bassel-Duby, and E. N. Olson (2007)
Mol. Cell. Biol. 27, 8143-8151
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MEF2: a central regulator of diverse developmental programs.

M. J. Potthoff and E. N. Olson (2007)
Development 134, 4131-4140
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a New Hybrid Serum Response Factor and Myocyte Enhancer Factor 2-binding Element in MyoD Enhancer Required for MyoD Expression during Myogenesis.

A. L'honore, V. Rana, N. Arsic, C. Franckhauser, N. J. Lamb, and A. Fernandez (2007)
Mol. Biol. Cell 18, 1992-2001
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Regulation of HDAC9 Gene Expression by MEF2 Establishes a Negative-Feedback Loop in the Transcriptional Circuitry of Muscle Differentiation.

M. Haberland, M. A. Arnold, J. McAnally, D. Phan, Y. Kim, and E. N. Olson (2007)
Mol. Cell. Biol. 27, 518-525
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The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.

H. Shen, A. S. McElhinny, Y. Cao, P. Gao, J. Liu, R. Bronson, J. D. Griffin, and L. Wu (2006)
Genes & Dev. 20, 675-688
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Loss of myogenin in postnatal life leads to normal skeletal muscle but reduced body size.

J. R. Knapp, J. K. Davie, A. Myer, E. Meadows, E. N. Olson, and W. H. Klein (2006)
Development 133, 601-610
 |  Abstract »  |  Full Text »  |  PDF »

Coplanar Polychlorinated Biphenyls Activate the Aryl Hydrocarbon Receptor in Developing Tissues of Two TCDD-Responsive lacZ Mouse Lines.

J. C. Bemis, D. A. Nazarenko, and T. A. Gasiewicz (2005)
Toxicol. Sci. 87, 529-536
 |  Abstract »  |  Full Text »  |  PDF »

Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2.

O. Nakagawa, M. Arnold, M. Nakagawa, H. Hamada, J. M. Shelton, H. Kusano, T. M. Harris, G. Childs, K. P. Campbell, J. A. Richardson, et al. (2005)
Genes & Dev. 19, 2066-2077
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The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription.

S. J. Tapscott (2005)
Development 132, 2685-2695
 |  Abstract »  |  Full Text »  |  PDF »

BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart.

D. Phan, T. L. Rasmussen, O. Nakagawa, J. McAnally, P. D. Gottlieb, P. W. Tucker, J. A. Richardson, R. Bassel-Duby, and E. N. Olson (2005)
Development 132, 2669-2678
 |  Abstract »  |  Full Text »  |  PDF »

Myocyte Enhancer Factor 2 Acetylation by p300 Enhances Its DNA Binding Activity, Transcriptional Activity, and Myogenic Differentiation.

K. Ma, J. K. L. Chan, G. Zhu, and Z. Wu (2005)
Mol. Cell. Biol. 25, 3575-3582
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Regulation of {alpha}-Smooth Muscle Actin Expression in Granulation Tissue Myofibroblasts Is Dependent on the Intronic CArG Element and the Transforming Growth Factor-{beta}1 Control Element.

J. J. Tomasek, J. McRae, G. K. Owens, and C. J. Haaksma (2005)
Am. J. Pathol. 166, 1343-1351
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice.

S. Li, M. P. Czubryt, J. McAnally, R. Bassel-Duby, J. A. Richardson, F. F. Wiebel, A. Nordheim, and E. N. Olson (2005)
PNAS 102, 1082-1087
 |  Abstract »  |  Full Text »  |  PDF »

The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation.

G. Caretti, M. Di Padova, B. Micales, G. E. Lyons, and V. Sartorelli (2004)
Genes & Dev. 18, 2627-2638
 |  Abstract »  |  Full Text »  |  PDF »

Paraxis Is a Basic Helix-Loop-Helix Protein That Positively Regulates Transcription through Binding to Specific E-box Elements.

J. Wilson-Rawls, J. M. Rhee, and A. Rawls (2004)
J. Biol. Chem. 279, 37685-37692
 |  Abstract »  |  Full Text »  |  PDF »

HRC Is a Direct Transcriptional Target of MEF2 during Cardiac, Skeletal, and Arterial Smooth Muscle Development In Vivo.

J. P. Anderson, E. Dodou, A. B. Heidt, S. J. De Val, E. J. Jaehnig, S. B. Greene, E. N. Olson, and B. L. Black (2004)
Mol. Cell. Biol. 24, 3757-3768
 |  Abstract »  |  Full Text »  |  PDF »

Myf5 expression in somites and limb buds of mouse embryos is controlled by two distinct distal enhancer activities.

A. Buchberger, N. Nomokonova, and H.-H. Arnold (2003)
Development 130, 3297-3307
 |  Abstract »  |  Full Text »  |  PDF »

Altered myogenesis in Six1-deficient mice.

C. Laclef, G. Hamard, J. Demignon, E. Souil, C. Houbron, and P. Maire (2003)
Development 130, 2239-2252
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Alteration of Mesodermal Cell Differentiation by EWS/FLI-1, the Oncogene Implicated in Ewing's Sarcoma.

S. Eliazer, J. Spencer, D. Ye, E. Olson, and R. L. Ilaria Jr. (2003)
Mol. Cell. Biol. 23, 482-492
 |  Abstract »  |  Full Text »  |  PDF »

Caspase 3 activity is required for skeletal muscle differentiation.

P. Fernando, J. F. Kelly, K. Balazsi, R. S. Slack, and L. A. Megeney (2002)
PNAS 99, 11025-11030
 |  Abstract »  |  Full Text »  |  PDF »

The early epaxial enhancer is essential for the initial expression of the skeletal muscle determination gene Myf5 but not for subsequent, multiple phases of somitic myogenesis.

L. Teboul, J. Hadchouel, P. Daubas, D. Summerbell, M. Buckingham, and P. W. J. Rigby (2002)
Development 129, 4571-4580
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Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding.

D. G. McFadden, J. McAnally, J. A. Richardson, J. Charite, and E. N. Olson (2002)
Development 129, 3077-3088
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Cis-DNA Regions Controlling Bmp4 Expression during Tooth Morphogenesis in vivo.

J.Q. Feng, J. Zhang, X. Tan, Y. Lu, D. Guo, and S.E. Harris (2002)
J. Dent. Res. 81, 6-10
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Molecular Dissection of DNA Sequences and Factors Involved in Slow Muscle-Specific Transcription.

S. Calvo, D. Vullhorst, P. Venepally, J. Cheng, I. Karavanova, and A. Buonanno (2001)
Mol. Cell. Biol. 21, 8490-8503
 |  Abstract »  |  Full Text »  |  PDF »

The Mef2c gene is a direct transcriptional target of myogenic bHLH and MEF2 proteins during skeletal muscle development.

D.-Z. Wang, M. R. Valdez, J. McAnally, J. Richardson, and E. N. Olson (2001)
Development 128, 4623-4633
 |  Abstract »  |  Full Text »  |  PDF »

A BAC transgenic analysis of the Mrf4/Myf5 locus reveals interdigitated elements that control activation and maintenance of gene expression during muscle development.

J. Carvajal, D Cox, D Summerbell, and P. Rigby (2001)
Development 128, 1857-1868
 |  Abstract »  |  PDF »

Identification of NKL, a novel Gli-Kruppel zinc-finger protein that promotes neuronal differentiation.

E Lamar, C Kintner, and M Goulding (2001)
Development 128, 1335-1346
 |  Abstract »  |  PDF »

Inaugural Article: The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis.

J. Lu, P. Chang, J. A. Richardson, L. Gan, H. Weiler, and E. N. Olson (2000)
PNAS 97, 9525-9530
 |  Abstract »  |  Full Text »  |  PDF »

A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart.

D. McFadden, J Charite, J. Richardson, D Srivastava, A. Firulli, and E. Olson (2000)
Development 127, 5331-5341
 |  Abstract »  |  PDF »

The expression of Myf5 in the developing mouse embryo is controlled by discrete and dispersed enhancers specific for particular populations of skeletal muscle precursors.

D Summerbell, P. Ashby, O Coutelle, D Cox, S Yee, and P. Rigby (2000)
Development 127, 3745-3757
 |  Abstract »  |  PDF »

Myocyte Enhancer Factor 2C and Myogenin Up-regulate Each Other's Expression and Induce the Development of Skeletal Muscle in P19 Cells.

A. G. Ridgeway, S. Wilton, and I. S. Skerjanc (2000)
J. Biol. Chem. 275, 41-46
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of retinoic acid signaling during lung morphogenesis.

S Malpel, C Mendelsohn, and W. Cardoso (2000)
Development 127, 3057-3067
 |  Abstract »  |  PDF »

Transdifferentiation of esophageal smooth to skeletal muscle is myogenic bHLH factor-dependent.

B Kablar, S Tajbakhsh, and M. Rudnicki (2000)
Development 127, 1627-1639
 |  Abstract »  |  PDF »

Regulation of Smooth Muscle {alpha}-Actin Expression In Vivo Is Dependent on CArG Elements Within the 5' and First Intron Promoter Regions.

C. P. Mack and G. K. Owens (1999)
Circ. Res. 84, 852-861
 |  Abstract »  |  Full Text »  |  PDF »

Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis.

D Brown, D Wagner, X Li, J. Richardson, and E. Olson (1999)
Development 126, 4317-4329
 |  Abstract »  |  PDF »

Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene.

F. Naya, C Wu, J. Richardson, P Overbeek, and E. Olson (1999)
Development 126, 2045-2052
 |  Abstract »  |  PDF »

prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme.

M. Lu, H. Cheng, M. Kern, S. Potter, B Tran, T. Diekwisch, and J. Martin (1999)
Development 126, 495-504
 |  Abstract »  |  PDF »

Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer.

C. Lien, C Wu, B Mercer, R Webb, J. Richardson, and E. Olson (1999)
Development 126, 75-84
 |  Abstract »  |  PDF »

Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site.

F. Spitz, J. Demignon, A. Porteu, A. Kahn, J.-P. Concordet, D. Daegelen, and P. Maire (1998)
PNAS 95, 14220-14225
 |  Abstract »  |  Full Text »  |  PDF »

The N-terminal Methionine Is a Major Determinant of the DNA Binding Specificity of MEF-2C.

D. Meierhans and R. K. Allemann (1998)
J. Biol. Chem. 273, 26052-26060
 |  Abstract »  |  Full Text »  |  PDF »

Synergistic Activation of the N-Methyl-D-aspartate Receptor Subunit 1 Promoter by Myocyte Enhancer Factor 2C and Sp1.

D. Krainc, G. Bai, S.-i. Okamoto, M. Carles, J. W. Kusiak, R. N. Brent, and S. A. Lipton (1998)
J. Biol. Chem. 273, 26218-26224
 |  Abstract »  |  Full Text »  |  PDF »

Smooth Muscle–Specific Expression of the Smooth Muscle Myosin Heavy Chain Gene in Transgenic Mice Requires 5'-Flanking and First Intronic DNA Sequence.

C. S. Madsen, C. P. Regan, J. E. Hungerford, S. L. White, I. Manabe, and G. K. Owens (1998)
Circ. Res. 82, 908-917
 |  Abstract »  |  Full Text »  |  PDF »

The Rho Family G Proteins Play a Critical Role in Muscle Differentiation.

H. Takano, I. Komuro, T. Oka, I. Shiojima, Y. Hiroi, T. Mizuno, and Y. Yazaki (1998)
Mol. Cell. Biol. 18, 1580-1589
 |  Abstract »  |  Full Text »

Requirement of the MADS-box transcription factor MEF2C for vascular development.

Q Lin, J Lu, H Yanagisawa, R Webb, G. Lyons, J. Richardson, and E. Olson (1998)
Development 125, 4565-4574
 |  Abstract »  |  PDF »

A distinct developmental programme for the cranial paraxial mesoderm in the chick embryo.

A Hacker and S Guthrie (1998)
Development 125, 3461-3472
 |  Abstract »  |  PDF »

A Minimal Murine Msx-1 Gene Promoter. ORGANIZATION OF ITS cis-REGULATORY MOTIFS AND THEIR ROLE IN TRANSCRIPTIONAL ACTIVATION IN CELLS IN CULTURE AND IN TRANSGENIC MICE.

T. Takahashi, C. Guron, S. Shetty, H. Matsui, and R. Raghow (1997)
J. Biol. Chem. 272, 22667-22678
 |  Abstract »  |  Full Text »  |  PDF »

GATA4 transcription factor is required for ventral morphogenesis and heart tube formation..

C T Kuo, E E Morrisey, R Anandappa, K Sigrist, M M Lu, M S Parmacek, C Soudais, and J M Leiden (1997)
Genes & Dev. 11, 1048-1060
 |  Abstract »  |  PDF »

Two domains of MyoD mediate transcriptional activation of genes in repressive chromatin: a mechanism for lineage determination in myogenesis..

A N Gerber, T R Klesert, D A Bergstrom, and S J Tapscott (1997)
Genes & Dev. 11, 436-450
 |  Abstract »  |  PDF »

Myogenin can substitute for Myf5 in promoting myogenesis but less efficiently.

Y Wang and R Jaenisch (1997)
Development 124, 2507-2513
 |  Abstract »  |  PDF »

Distinct Domains of Myocyte Enhancer Binding Factor-2A Determining Nuclear Localization and Cell Type-specific Transcriptional Activity.

Y.-T. Yu and Y. T. Yu (1996)
J. Biol. Chem. 271, 24675-24683
 |  Abstract »  |  Full Text »  |  PDF »

MEF2 Protein Expression, DNA Binding Specificity and Complex Composition, and Transcriptional Activity in Muscle and Non-muscle Cells.

O. I. Ornatsky and J. C. McDermott (1996)
J. Biol. Chem. 271, 24927-24933
 |  Abstract »  |  Full Text »  |  PDF »

Structure and Expression of the Murine Muscle Adenylosuccinate Synthetase Gene.

A. L. Lewis, O. M. Guicherit, S. K. Datta, G. R. Hanten, and R. E. Kellems (1996)
J. Biol. Chem. 271, 22647-22656
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of Myogenic Differentiation by a Neuregulin, Glial Growth Factor 2. ARE NEUREGULINS THE LONG-SOUGHT MUSCLE TROPHIC FACTORS SECRETED BY NERVES?.

J. R. Florini, D. S. Samuel, D. Z. Ewton, C. Kirk, and R. M. Sklar (1996)
J. Biol. Chem. 271, 12699-12702
 |  Abstract »  |  Full Text »  |  PDF »

Myocyte Enhancer Binding Factor-2 Expression and Activity in Vascular Smooth Muscle Cells : Association With the Activated Phenotype.

A. B. Firulli, J. M. Miano, W. Bi, A. D. Johnson, W. Casscells, E. N. Olson, and J. J. Schwarz (1996)
Circ. Res. 78, 196-204
 |  Abstract »  |  Full Text »

Functional Dissection of the Brain-specific Rat Aldolase C Gene Promoter in Transgenic Mice.

M. Thomas, H. Skala, A. Kahn, and F.ço. P. D. Tuy (1995)
J. Biol. Chem. 270, 20316-20321
 |  Abstract »  |  Full Text »  |  PDF »

Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies..

W Zhang, R R Behringer, and E N Olson (1995)
Genes & Dev. 9, 1388-1399
 |  Abstract »  |  PDF »

Drosophila MEF2, a transcription factor that is essential for myogenesis..

B A Bour, M A O'Brien, W L Lockwood, E S Goldstein, R Bodmer, P H Taghert, S M Abmayr, and H T Nguyen (1995)
Genes & Dev. 9, 730-741
 |  Abstract »  |  PDF »

The Mouse MRF4 Promoter Is trans-Activated Directly and Indirectly by Muscle-specific Transcription Factors.

B. L. Black, J. F. Martin, and E. N. Olson (1995)
J. Biol. Chem. 270, 2889-2892
 |  Abstract »  |  Full Text »  |  PDF »

Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila.

B Lilly, B Zhao, G Ranganayakulu, B. Paterson, R. Schulz, and E. Olson (1995)
Science 267, 688-693
 |  Abstract »  |  PDF »

tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman.

S. Evans, W Yan, M. Murillo, J Ponce, and N Papalopulu (1995)
Development 121, 3889-3899
 |  Abstract »  |  PDF »

Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome.

A Patapoutian, J. Yoon, J. Miner, S Wang, K Stark, and B Wold (1995)
Development 121, 3347-3358
 |  Abstract »  |  PDF »

Embryonic activation of the myoD gene is regulated by a highly conserved distal control element.

D. Goldhamer, B. Brunk, A Faerman, A King, M Shani, and C. Emerson (1995)
Development 121, 637-649
 |  Abstract »  |  PDF »

Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD.

S Kaushal, J. Schneider, B Nadal-Ginard, and V Mahdavi (1994)
Science 266, 1236-1240
 |  Abstract »  |  PDF »

The RSRF/MEF2 protein SL1 regulates cardiac muscle-specific transcription of a myosin light-chain gene in Xenopus embryos..

A E Chambers, M Logan, S Kotecha, N Towers, D Sparrow, and T J Mohun (1994)
Genes & Dev. 8, 1324-1334
 |  Abstract »  |  PDF »

Separate pathways for synapse-specific and electrical activity-dependent gene expression in skeletal muscle.

J Tang, S. Jo, and S. Burden (1994)
Development 120, 1799-1804
 |  Abstract »  |  PDF »

Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis.

D. Edmondson, G. Lyons, J. Martin, and E. Olson (1994)
Development 120, 1251-1263
 |  Abstract »  |  PDF »

Muscle pattern diversification in Drosophila is determined by the autonomous function of homeotic genes in the embryonic mesoderm.

A. Michelson (1994)
Development 120, 755-768
 |  Abstract »  |  PDF »

bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out..

E N Olson and W H Klein (1994)
Genes & Dev. 8, 1-8
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Phosphoinositide 3-Kinase Induces the Transcriptional Activity of MEF2 Proteins during Muscle Differentiation.

Y. Tamir and E. Bengal (2000)
J. Biol. Chem. 275, 34424-34432
 |  Abstract »  |  Full Text »  |  PDF »

Positive- and Negative-acting Kruppel-like Transcription Factors Bind a Transforming Growth Factor beta Control Element Required for Expression of the Smooth Muscle Cell Differentiation Marker SM22alpha in Vivo.

P. J. Adam, C. P. Regan, M. B. Hautmann, and G. K. Owens (2000)
J. Biol. Chem. 275, 37798-37806
 |  Abstract »  |  Full Text »  |  PDF »

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