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Science 16 July 1993:
Vol. 261. no. 5119, pp. 355 - 358
DOI: 10.1126/science.8332900
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Articles

Science, Vol 261, Issue 5119, 355-358
Copyright © 1993 by American Association for the Advancement of Science

articles

Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes

JD Thomas, P Sideras, CI Smith, I Vorechovsky, V Chapman, and WE Paul

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.

Mice that bear the X-linked immunodeficiency (xid) mutation have a B lymphocyte-specific defect resulting in an inability to make antibody responses to polysaccharide antigens. A backcross of 1114 progeny revealed the colocalization of xid with Bruton's agammaglobulinemia tyrosine kinase (btk) gene, which is implicated in the human immune deficiency, X-linked agammaglobulinemia. Mice that carry xid have a missense mutation that alters a highly conserved arginine near the amino-terminus of the btk protein, Btk. Because this region of Btk lies outside any obvious kinase domain, the xid mutation may define another aspect of tyrosine kinase function.


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B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–derived Signals.
F. Loder, B. Mutschler, R. J. Ray, C. J. Paige, P. Sideras, R. Torres, M. C. Lamers, and R. Carsetti (1999)
J. Exp. Med. 190, 75-90
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Regulation of Nuclear Localization and Transcriptional Activity of TFII-I by Bruton's Tyrosine Kinase.
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Involvement of Wiskott-Aldrich Syndrome Protein in B-Cell Cytoplasmic Tyrosine Kinase Pathway.
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   Abstract »    Full Text »    PDF »
{gamma}3 Gene-Disrupted Mice Selectively Deficient in the Dominant IgG Subclass Made to Bacterial Polysaccharides Undergo Normal Isotype Switching After Immunization with Polysaccharide-Protein Conjugate Vaccines.
D. A. Shapiro, D. S. Threadgill, M. J. Copfer, D. A. Corey, T. L. McCool, L. L. McCormick, T. R. Magnuson, N. S. Greenspan, and J. R. Schreiber (1998)
J. Immunol. 161, 3393-3399
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Independent and Opposing Roles For Btk and Lyn in B and Myeloid Signaling Pathways.
A. B. Satterthwaite, C. A. Lowell, W. N. Khan, P. Sideras, F. W. Alt, and O. N. Witte (1998)
J. Exp. Med. 188, 833-844
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The mechanism of IL-5 signal transduction.
T. Adachi and R. Alam (1998)
Am J Physiol Cell Physiol 275, C623-C633
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Involvement of Ras in Bruton's Tyrosine Kinase-mediated JNK Activation.
J. Deng, Y. Kawakami, S. E. Hartman, T. Satoh, and T. Kawakami (1998)
J. Biol. Chem. 273, 16787-16791
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T Cell Receptor-initiated Calcium Release Is Uncoupled from Capacitative Calcium Entry in Itk-deficient T Cells.
K.-Q. Liu, S. C. Bunnell, C. B. Gurniak, and L. J. Berg (1998)
J. Exp. Med. 187, 1721-1727
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Bruton's Tyrosine Kinase-mediated Interleukin-2 Gene Activation in Mast Cells. DEPENDENCE ON THE c-Jun N-TERMINAL KINASE ACTIVATION PATHWAY.
D. Hata, J. Kitaura, S. E. Hartman, Y. Kawakami, T. Yokota, and T. Kawakami (1998)
J. Biol. Chem. 273, 10979-10987
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