Related Content
Search Google Scholar for:
|
|
Science 6 August 1993:
Vol. 261. no. 5122, pp. 765 - 769
DOI: 10.1126/science.7688144
|
|
Articles
Science, Vol 261, Issue 5122, 765-769
Copyright © 1993 by American Association for the Advancement of Science
Primers for mitochondrial DNA replication generated by endonuclease G
J Cote
and
A Ruiz-Carrillo
Cancer Research Center, Medical School of Laval University, L'Hotel-Dieu de Quebec, Canada.
Endonuclease G (Endo G) is widely distributed among animals and cleaves DNA at double-stranded (dG)n.(dC)n and at single-stranded (dC)n tracts. Endo G is synthesized as a propeptide with an amino-terminal presequence that targets the nuclease to mitochondria. Endo G can also be detected in extranucleolar chromatin. In addition to deoxyribonuclease activities, Endo G also has ribonuclease (RNase) and RNase H activities and specifically cleaves mouse mitochondrial RNA and DNA-RNA substrates containing the origin of heavy-strand DNA replication (OH). The cleavage sites match those found in vivo, indicating that Endo G is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- EXOG, a novel paralog of Endonuclease G in higher eukaryotes.
- I. A. Cymerman, I. Chung, B. M. Beckmann, J. M. Bujnicki, and G. Meiss (2008)
Nucleic Acids Res.
36, 1369-1379
| Abstract »
| Full Text »
| PDF »
- Expression of a novel non-coding mitochondrial RNA in human proliferating cells.
- J. Villegas, V. Burzio, C. Villota, E. Landerer, R. Martinez, M. Santander, R. Martinez, R. Pinto, M. I. Vera, E. Boccardo, et al. (2007)
Nucleic Acids Res.
35, 7336-7347
| Abstract »
| Full Text »
| PDF »
- Nuclear translocation of EndoG at the initiation of disuse muscle atrophy and apoptosis is specific to myonuclei.
- E. E. Dupont-Versteegden, B. A. Strotman, C. M. Gurley, D. Gaddy, M. Knox, J. D. Fluckey, and C. A. Peterson (2006)
Am J Physiol Regulatory Integrative Comp Physiol
291, R1730-R1740
| Abstract »
| Full Text »
| PDF »
- Mitochondrial Functions and Estrogen Receptor-dependent Nuclear Translocation of Pleiotropic Human Prohibitin 2.
- K. Kasashima, E. Ohta, Y. Kagawa, and H. Endo (2006)
J. Biol. Chem.
281, 36401-36410
| Abstract »
| Full Text »
| PDF »
- Endonuclease G: A role for the enzyme in recombination and cellular proliferation.
- K.-J. Huang, C.-C. Ku, and I. R. Lehman (2006)
PNAS
103, 8995-9000
| Abstract »
| Full Text »
| PDF »
- Mature DIABLO/Smac Is Produced by the IMP Protease Complex on the Mitochondrial Inner Membrane.
- L. Burri, Y. Strahm, C. J. Hawkins, I. E. Gentle, M. A. Puryer, A. Verhagen, B. Callus, D. Vaux, and T. Lithgow (2005)
Mol. Biol. Cell
16, 2926-2933
| Abstract »
| Full Text »
| PDF »
- Generation and Characterization of Endonuclease G Null Mice.
- R. A. Irvine, N. Adachi, D. K. Shibata, G. D. Cassell, K. Yu, Z. E. Karanjawala, C.-L. Hsieh, and M. R. Lieber (2005)
Mol. Cell. Biol.
25, 294-302
| Abstract »
| Full Text »
| PDF »
- Vulnerability of Central Neurons to Secondary Insults after In Vitro Mechanical Stretch.
- M. Arundine, M. Aarts, A. Lau, and M. Tymianski (2004)
J. Neurosci.
24, 8106-8123
| Abstract »
| Full Text »
| PDF »
- Endonuclease G is required for early embryogenesis and normal apoptosis in mice.
- J. Zhang, M. Dong, L. Li, Y. Fan, P. Pathre, J. Dong, D. Lou, J. M. Wells, D. Olivares-Villagomez, L. Van Kaer, et al. (2003)
PNAS
100, 15782-15787
| Abstract »
| Full Text »
| PDF »
- A Ca2+-induced mitochondrial permeability transition causes complete release of rat liver endonuclease G activity from its exclusive location within the mitochondrial intermembrane space. Identification of a novel endo-exonuclease activity residing within the mitochondrial matrix.
- A. M. Davies, S. Hershman, G. J. Stabley, J. B. Hoek, J. Peterson, and A. Cahill (2003)
Nucleic Acids Res.
31, 1364-1373
| Abstract »
| Full Text »
| PDF »
- Endonuclease G, a Candidate Human Enzyme for the Initiation of Genomic Inversion in Herpes Simplex Type 1 Virus.
- K.-J. Huang, B. V. Zemelman, and I. R. Lehman (2002)
J. Biol. Chem.
277, 21071-21079
| Abstract »
| Full Text »
| PDF »
- Action of Recombinant Human Apoptotic Endonuclease G on Naked DNA and Chromatin Substrates. COOPERATION WITH EXONUCLEASE AND DNase I.
- P. Widlak, L. Y. Li, X. Wang, and W. T. Garrard (2001)
J. Biol. Chem.
276, 48404-48409
| Abstract »
| Full Text »
| PDF »
- The expanding role of mitochondria in apoptosis.
- X. Wang (2001)
Genes & Dev.
15, 2922-2933
| Full Text »
| PDF »
- Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process.
- S. A. Susin, H. K. Lorenzo, N. Zamzami, I. Marzo, C. Brenner, N. Larochette, M.-C. Prevost, P. M. Alzari, and G. Kroemer (1999)
J. Exp. Med.
189, 381-394
| Abstract »
| Full Text »
| PDF »
- On the Advantage of Being a Dimer, a Case Study Using the Dimeric Serratia Nuclease and the Monomeric Nuclease from Anabaena sp. Strain PCC 7120.
- I. Franke, G. Meiss, and A. Pingoud (1999)
J. Biol. Chem.
274, 825-832
| Abstract »
| Full Text »
| PDF »
- Initiation of Mitochondrial DNA Replication by Transcription and R-loop Processing.
- D. Y. Lee and D. A. Clayton (1998)
J. Biol. Chem.
273, 30614-30621
| Abstract »
| Full Text »
| PDF »
- Transcription-Dependent DNA Transactions in the Mitochondrial Genome of a Yeast Hypersuppressive Petite Mutant.
- E. Van Dyck and D. A. Clayton (1998)
Mol. Cell. Biol.
18, 2976-2985
| Abstract »
| Full Text »
- RNase mitochondrial RNA processing correctly cleaves a novel R loop at the mitochondrial DNA leading-strand origin of replication..
- D Y Lee and D A Clayton (1997)
Genes & Dev.
11, 582-592
| Abstract »
| PDF »
- The POP1 gene encodes a protein component common to the RNase MRP and RNase P ribonucleoproteins..
- Z Lygerou, P Mitchell, E Petfalski, B Seraphin, and D Tollervey (1994)
Genes & Dev.
8, 1423-1433
| Abstract »
| PDF »
|
|
