Science 20 August 1993: Vol. 261. no. 5124, pp. 1004 - 1012 DOI: 10.1126/science.8351515

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Articles

Enzyme Kinetics of GTI-2040, a Phosphorothioate Oligonucleotide Targeting Ribonucleotide Reductase.

X. Wei, G. Dai, Z. Liu, H. Cheng, Z. Xie, R. Klisovic, G. Marcucci, and K. K. Chan (2008)
Drug Metab. Dispos. 36, 2227-2233
 |  Abstract »  |  Full Text »  |  PDF »

Effective inhibition in animals of viral pathogenesis by a ribozyme derived from RNase P catalytic RNA.

Y. Bai, P. Trang, H. Li, K. Kim, T. Zhou, and F. Liu (2008)
PNAS 105, 10919-10924
 |  Abstract »  |  Full Text »  |  PDF »

2'-Fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity.

J. K. Watts, N. Choubdar, K. Sadalapure, F. Robert, A. S. Wahba, J. Pelletier, B. Mario Pinto, and M. J. Damha (2007)
Nucleic Acids Res. 35, 1441-1451
 |  Abstract »  |  Full Text »  |  PDF »

Antiadhesive Effects of GRN163L--An Oligonucleotide N3'->P5' Thio-Phosphoramidate Targeting Telomerase.

S. R. Jackson, C.-H. Zhu, V. Paulson, L. Watkins, Z. G. Dikmen, S. M. Gryaznov, W. E. Wright, and J. W. Shay (2007)
Cancer Res. 67, 1121-1129
 |  Abstract »  |  Full Text »  |  PDF »

Engineered external guide sequences are highly effective in inducing RNase P for inhibition of gene expression and replication of human cytomegalovirus.

Y.-H. Yang, H. Li, T. Zhou, K. Kim, and F. Liu (2006)
Nucleic Acids Res. 34, 575-583
 |  Abstract »  |  Full Text »  |  PDF »

Effective inhibition of human cytomegalovirus gene expression and growth by intracellular expression of external guide sequence RNA.

H. LI, P. TRANG, K. KIM, T. ZHOU, S. UMAMOTO, and F. LIU (2006)
RNA 12, 63-72
 |  Abstract »  |  Full Text »  |  PDF »

Single-Strand Conformation Polymorphism (SSCP) of Oligodeoxyribonucleotides: An Insight into Solution Structural Dynamics of DNAs Provided by Gel Electrophoresis and Molecular Dynamics Simulations.

M. Biyani and K. Nishigaki (2005)
J. Biochem. 138, 363-373
 |  Abstract »  |  Full Text »  |  PDF »

Immunostimulatory CpG Oligonucleotides Abrogate Allergic Susceptibility in a Murine Model of Maternal Asthma Transmission.

A. Fedulov, E. Silverman, Y. Xiang, A. Leme, and L. Kobzik (2005)
J. Immunol. 175, 4292-4300
 |  Abstract »  |  Full Text »  |  PDF »

Dissecting human cytomegalovirus gene function and capsid maturation by ribozyme targeting and electron cryomicroscopy.

X. Yu, P. Trang, S. Shah, I. Atanasov, Y.-H. Kim, Y. Bai, Z. H. Zhou, and F. Liu (2005)
PNAS 102, 7103-7108
 |  Abstract »  |  Full Text »  |  PDF »

Cellular Uptake and Intracellular Levels of the Bcl-2 Antisense G3139 in Cultured Cells and Treated Patients with Acute Myeloid Leukemia.

G. Dai, K. K. Chan, S. Liu, D. Hoyt, S. Whitman, M. Klisovic, T. Shen, M. A. Caligiuri, J. Byrd, M. Grever, et al. (2005)
Clin. Cancer Res. 11, 2998-3008
 |  Abstract »  |  Full Text »  |  PDF »

An Antisense Oligodeoxynucleotide Against Vascular Endothelial Growth Factor in a Nonhuman Primate Model of Iris Neovascularization.

R. B. Bhisitkul, G. S. Robinson, R. S. Moulton, K. P. Claffey, E. S. Gragoudas, and J. W. Miller (2005)
Arch Ophthalmol 123, 214-219
 |  Abstract »  |  Full Text »  |  PDF »

Peptide conjugates for chromosomal gene targeting by triplex-forming oligonucleotides.

F. A. Rogers, M. Manoharan, P. Rabinovitch, D. C. Ward, and P. M. Glazer (2004)
Nucleic Acids Res. 32, 6595-6604
 |  Abstract »  |  Full Text »  |  PDF »

Immune Cell-Mediated Antitumor Activities of GD2-Targeted Liposomal c-myb Antisense Oligonucleotides Containing CpG Motifs.

C. Brignole, F. Pastorino, D. Marimpietri, G. Pagnan, A. Pistorio, T. M. Allen, V. Pistoia, and M. Ponzoni (2004)
J Natl Cancer Inst 96, 1171-1180
 |  Abstract »  |  Full Text »  |  PDF »

Engineered RNase P Ribozymes Increase Their Cleavage Activities and Efficacies in Inhibiting Viral Gene Expression in Cells by Enhancing the Rate of Cleavage and Binding of the Target mRNA.

H. Zou, J. Lee, A. F. Kilani, K. Kim, P. Trang, J. Kim, and F. Liu (2004)
J. Biol. Chem. 279, 32063-32070
 |  Abstract »  |  Full Text »  |  PDF »

Effective inhibition of Rta expression and lytic replication of Kaposi's sarcoma-associated herpesvirus by human RNase P.

J. Zhu, P. Trang, K. Kim, T. Zhou, H. Deng, and F. Liu (2004)
PNAS 101, 9073-9078
 |  Abstract »  |  Full Text »  |  PDF »

Attenuation of HIV-1 Replication in Primary Human Cells with a Designed Zinc Finger Transcription Factor.

D. J. Segal, J. Goncalves, S. Eberhardy, C. H. Swan, B. E. Torbett, X. Li, and C. F. Barbas III (2004)
J. Biol. Chem. 279, 14509-14519
 |  Abstract »  |  Full Text »  |  PDF »

Nonmethylated CG Motifs Packaged into Virus-Like Particles Induce Protective Cytotoxic T Cell Responses in the Absence of Systemic Side Effects.

T. Storni, C. Ruedl, K. Schwarz, R. A. Schwendener, W. A. Renner, and M. F. Bachmann (2004)
J. Immunol. 172, 1777-1785
 |  Abstract »  |  Full Text »  |  PDF »

Triplex-forming oligonucleotide target sequences in the human genome.

J. R. Goni, X. de la Cruz, and M. Orozco (2004)
Nucleic Acids Res. 32, 354-360
 |  Abstract »  |  Full Text »  |  PDF »

Immune-Responsive Gene 1 Is a Novel Target of Progesterone Receptor and Plays a Critical Role during Implantation in the Mouse.

Y.-P. Cheon, X. Xu, M. K. Bagchi, and I. C. Bagchi (2003)
Endocrinology 144, 5623-5630
 |  Abstract »  |  Full Text »  |  PDF »

Targeted Liposomal c-myc Antisense Oligodeoxynucleotides Induce Apoptosis and Inhibit Tumor Growth and Metastases in Human Melanoma Models.

F. Pastorino, C. Brignole, D. Marimpietri, G. Pagnan, A. Morando, D. Ribatti, S. C. Semple, C. Gambini, T. M. Allen, and M. Ponzoni (2003)
Clin. Cancer Res. 9, 4595-4605
 |  Abstract »  |  Full Text »  |  PDF »

G3139 (oblimersen) may inhibit prostate cancer cell growth in a partially bis-CpG-dependent non-antisense manner.

J. C. Lai, L. Benimetskaya, R. M. Santella, Q. Wang, P. S. Miller, and C. A. Stein (2003)
Mol. Cancer Ther. 2, 1031-1043
 |  Abstract »  |  Full Text »

Targeting of iNOS with antisense DNA plasmid reduces cytokine-induced inhibition of osteoblastic activity.

T. Abe, H. Hikiji, W. S. Shin, N. Koshikiya, S.-i. Shima, J. Nakata, T. Susami, T. Takato, and T. Toyo-oka (2003)
Am J Physiol Endocrinol Metab 285, E614-E621
 |  Abstract »  |  Full Text »  |  PDF »

Antisense Oligonucleotides Targeting XIAP Induce Apoptosis and Enhance Chemotherapeutic Activity against Human Lung Cancer Cells in Vitro and in Vivo.

Y. Hu, G. Cherton-Horvat, V. Dragowska, S. Baird, R. G. Korneluk, J. P. Durkin, L. D. Mayer, and E. C. LaCasse (2003)
Clin. Cancer Res. 9, 2826-2836
 |  Abstract »  |  Full Text »  |  PDF »

Imaging of Vascular Gene Therapy.

X. Yang (2003)
Radiology 228, 36-49
 |  Abstract »  |  Full Text »  |  PDF »

In vivo imaging with oligonucleotides for diagnosis and drug development.

B Tavitian (2003)
Gut 52, iv40-47
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Mouse Pellino-2 Modulates IL-1 and Lipopolysaccharide Signaling.

K.-Y. Yu, H.-J. Kwon, D. A. M. Norman, E. Vig, M. G. Goebl, and M. A. Harrington (2002)
J. Immunol. 169, 4075-4078
 |  Abstract »  |  Full Text »  |  PDF »

Colony-stimulating Factor-1 Antisense Treatment Suppresses Growth of Human Tumor Xenografts in Mice.

S. Aharinejad, D. Abraham, P. Paulus, H. Abri, M. Hofmann, K. Grossschmidt, R. Schafer, E. R. Stanley, and R. Hofbauer (2002)
Cancer Res. 62, 5317-5324
 |  Abstract »  |  Full Text »  |  PDF »

In Vitro Selection of External Guide Sequences for Directing RNase P-mediated Inhibition of Viral Gene Expression.

T. Zhou, J. Kim, A. F. Kilani, K. Kim, W. Dunn, S. Jo, E. Nepomuceno, and F. Liu (2002)
J. Biol. Chem. 277, 30112-30120
 |  Abstract »  |  Full Text »  |  PDF »

Molecular requirements for degradation of a modified sense RNA strand by Escherichia coli ribonuclease H1.

D. R. Yazbeck, K.-L. Min, and M. J. Damha (2002)
Nucleic Acids Res. 30, 3015-3025
 |  Abstract »  |  Full Text »  |  PDF »

Design and characterization of decoy oligonucleotides containing locked nucleic acids.

R. Crinelli, M. Bianchi, L. Gentilini, and M. Magnani (2002)
Nucleic Acids Res. 30, 2435-2443
 |  Abstract »  |  Full Text »  |  PDF »

Antisense therapy for malignant mesothelioma with oligonucleotides targeting the bcl-xl gene product.

W. R. Smythe, I. Mohuiddin, M. Ozveran, and X. X. Cao (2002)
J. Thorac. Cardiovasc. Surg. 123, 1191-1198
 |  Abstract »  |  Full Text »  |  PDF »

Intramural coronary delivery of advanced antisense oligonucleotides reduces neointimal formation in the porcine stent restenosis model.

N. N. Kipshidze, H.-S. Kim, P. Iversen, H. A. Yazdi, B. Bhargava, G. New, R. Mehran, F. Tio, C. Haudenschild, G. Dangas, et al. (2002)
J. Am. Coll. Cardiol. 39, 1686-1691
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of murine macrophage nitric oxide production by synthetic oligonucleotides.

F.-G. Zhu, C. F. Reich, and D. S. Pisetsky (2002)
J. Leukoc. Biol. 71, 686-694
 |  Abstract »  |  Full Text »  |  PDF »

Antisense RNA Down-Regulation of bcl-xL Expression in Prostate Cancer Cells Leads to Diminished Rates of Cellular Proliferation and Resistance to Cytotoxic Chemotherapeutic Agents.

M. Vilenchik, A. J. Raffo, L. Benimetskaya, D. Shames, and C. A. Stein (2002)
Cancer Res. 62, 2175-2183
 |  Abstract »  |  Full Text »  |  PDF »

Pre- and Postnatal Lung Development, Maturation, and Plasticity: Antisense inhibition of surfactant protein A decreases tubular myelin formation in human fetal lung in vitro.

J. M. Klein, T. A. McCarthy, J. M. Dagle, and J. M. Snyder (2002)
Am J Physiol Lung Cell Mol Physiol 282, L386-L393
 |  Abstract »  |  Full Text »  |  PDF »

Antisense Oligonucleotides: Basic Concepts and Mechanisms.

N. Dias and C. A. Stein (2002)
Mol. Cancer Ther. 1, 347-355
 |  Full Text »  |  PDF »

Triplex formation by morpholino oligodeoxyribonucleotides in the HER-2/neu promoter requires the pyrimidine motif.

J. Basye, J. O. Trent, D. Gao, and S. W. Ebbinghaus (2001)
Nucleic Acids Res. 29, 4873-4880
 |  Abstract »  |  Full Text »  |  PDF »

Sense, Antisense, and Common Sense.

J.-L. C. Urbain (2001)
J. Nucl. Med. 42, 1670-1672
 |  Full Text »  |  PDF »

Tumor Targeting and Imaging of Intraperitoneal Tumors by Use of Antisense Oligo-DNA Complexed with Dendrimers and/or Avidin in Mice.

N. Sato, H. Kobayashi, T. Saga, Y. Nakamoto, T. Ishimori, K. Togashi, Y. Fujibayashi, J. Konishi, and M. W. Brechbiel (2001)
Clin. Cancer Res. 7, 3606-3612
 |  Abstract »  |  Full Text »  |  PDF »

Psoralen-modified clamp-forming antisense oligonucleotides reduce cellular c-Myc protein expression and B16-F0 proliferation.

D. A. Stewart, S. D. Thomas, C. A. Mayfield, and D. M. Miller (2001)
Nucleic Acids Res. 29, 4052-4061
 |  Abstract »  |  Full Text »  |  PDF »

A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells.

Z.-z. Su, I. V. Lebedeva, R. V. Gopalkrishnan, N. I. Goldstein, C. A. Stein, J. C. Reed, P. Dent, and P. B. Fisher (2001)
PNAS 98, 10332-10337
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Growth Inhibition in Vivo and G2/M Cell Cycle Arrest Induced by Antisense Oligodeoxynucleotide Targeting Thymidylate Synthase.

R. W. Berg, M. Werner, P. J. Ferguson, C. Postenka, M. Vincent, D. J. Koropatnick, and E. Behrend (2001)
J. Pharmacol. Exp. Ther. 298, 477-484
 |  Abstract »  |  Full Text »  |  PDF »

Specific Inhibition of Coxsackievirus B3 Translation and Replication by Phosphorothioate Antisense Oligodeoxynucleotides.

A. Wang, P. K. M. Cheung, H. Zhang, C. M. Carthy, L. Bohunek, J. E. Wilson, B. M. McManus, and D. Yang (2001)
Antimicrob. Agents Chemother. 45, 1043-1052
 |  Abstract »  |  Full Text »

Chemically Modified Ribozyme to V Gene Inhibits Anti-DNA Production and the Formation of Immune Deposits Caused by Lupus Lymphocytes.

Y. Suzuki, T. Funato, Y. Munakata, K. Sato, Y. Hirabayashi, T. Ishii, N. Takasawa, T. Ootaka, T. Saito, and T. Sasaki (2000)
J. Immunol. 165, 5900-5905
 |  Abstract »  |  Full Text »  |  PDF »

Effects of a Hexameric Deoxyriboguanosine Run Conjugation into CpG Oligodeoxynucleotides on Their Immunostimulatory Potentials.

S. W. Lee, M. K. Song, K. H. Baek, Y. Park, J. K. Kim, C. H. Lee, H.-K. Cheong, C. Cheong, and Y. C. Sung (2000)
J. Immunol. 165, 3631-3639
 |  Abstract »  |  Full Text »  |  PDF »

Deletion of Individual Exons and Induction of Soluble Murine Interleukin-5 Receptor-alpha Chain Expression through Antisense Oligonucleotide-Mediated Redirection of Pre-mRNA Splicing.

J. G. Karras, R. A. McKay, N. M. Dean, and B. P. Monia (2000)
Mol. Pharmacol. 58, 380-387
 |  Abstract »  |  Full Text »

RNA accessibility prediction: a theoretical approach is consistent with experimental studies in cell extracts.

M. Scherr, J. J. Rossi, G. Sczakiel, and V. Patzel (2000)
Nucleic Acids Res. 28, 2455-2461
 |  Abstract »  |  Full Text »  |  PDF »

Antisense to LOX-1 Inhibits Oxidized LDL-Mediated Upregulation of Monocyte Chemoattractant Protein-1 and Monocyte Adhesion to Human Coronary Artery Endothelial Cells.

D. Li and J. L. Mehta (2000)
Circulation 101, 2889-2895
 |  Abstract »  |  Full Text »  |  PDF »

Antisense Inhibition of Epidermal Growth Factor Receptor Decreases Expression of Human Surfactant Protein A.

J. M. Klein, T. A. McCarthy, J. M. Dagle, and J. M. Snyder (2000)
Am. J. Respir. Cell Mol. Biol. 22, 676-684
 |  Abstract »  |  Full Text »

Annexin 1 (Lipocortin 1) Mediates the Glucocorticoid Inhibition of Cyclic Adenosine 3',5'-Monophosphate-Stimulated Prolactin Secretion.

A. D. Taylor, J. G. Philip, C. D. John, P. O. Cover, J. F. Morris, R. J. Flower, and J. C. Buckingham (2000)
Endocrinology 141, 2209-2219
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Polypeptide Growth Factors in Human Carcinomas: New Targets for a Novel Pharmacological Approach.

R. E. Favoni and A. De Cupis (2000)
Pharmacol. Rev. 52, 179-206
 |  Abstract »  |  Full Text »  |  PDF »

Antisense and gene therapy to prevent restenosis.

A. Ehsan and M. J Mann (2000)
Vascular Medicine 5, 103-114
 |  Abstract »  |  PDF »

Inhibition of c-myc Expression in Cells by Targeting an RNA-Protein Interaction Using Antisense Oligonucleotides.

C. M. Coulis, C. Lee, V. Nardone, and R. D. Prokipcak (2000)
Mol. Pharmacol. 57, 485-494
 |  Abstract »  |  Full Text »

Identification, purification and partial characterisation of an oligonucleotide receptor in membranes of HepG2 cells.

P. d. Diesbach, C. Berens, F. N'Kuli, M. Monsigny, E. Sonveaux, R. Wattiez, and P. J. Courtoy (2000)
Nucleic Acids Res. 28, 868-874
 |  Abstract »  |  Full Text »  |  PDF »

Delivery of c-myb Antisense Oligodeoxynucleotides to Human Neuroblastoma Cells Via Disialoganglioside GD2-Targeted Immunoliposomes: Antitumor Effects.

G. Pagnan, D. D. Stuart, F. Pastorino, L. Raffaghello, P. G. Montaldo, T. M. Allen, B. Calabretta, and M. Ponzoni (2000)
J Natl Cancer Inst 92, 253-261
 |  Abstract »  |  Full Text »  |  PDF »

Treatment of Mycobacterium tuberculosis with antisense oligonucleotides to glutamine synthetase mRNA inhibits glutamine synthetase activity, formation of the poly-L-glutamate/glutamine cell wall structure, and bacterial replication.

G. Harth, P. C. Zamecnik, J.-Y. Tang, D. Tabatadze, and M. A. Horwitz (2000)
PNAS 97, 418-423
 |  Abstract »  |  Full Text »  |  PDF »

Oligonucleotides Tethered to a Short Polyguanylic Acid Stretch Are Targeted to Macrophages: Enhanced Antiviral Activity of a Vesicular Stomatitis Virus-Specific Antisense Oligonucleotide.

V. Prasad, S. Hashim, A. Mukhopadhyay, S. K. Basu, and R. P. Roy (1999)
Antimicrob. Agents Chemother. 43, 2689-2696
 |  Abstract »  |  Full Text »

Tumor Necrosis Factor-alpha Mediates Lipopolysaccharide-Induced Macrophage Inflammatory Protein-2 Release from Alveolar Epithelial Cells . Autoregulation in Host Defense.

A. M. Xavier, N. Isowa, L. Cai, E. Dziak, M. Opas, D. I. McRitchie, A. S. Slutsky, S. H. Keshavjee, and M. Liu (1999)
Am. J. Respir. Cell Mol. Biol. 21, 510-520
 |  Abstract »  |  Full Text »

Progression to Androgen Independence Is Delayed by Adjuvant Treatment with Antisense Bcl-2 Oligodeoxynucleotides after Castration in the LNCaP Prostate Tumor Model.

M. Gleave, A. Tolcher, H. Miyake, C. Nelson, B. Brown, E. Beraldi, and J. Goldie (1999)
Clin. Cancer Res. 5, 2891-2898
 |  Abstract »  |  Full Text »  |  PDF »

Efficient Nuclear Delivery of Antisense Oligodeoxynucleotides and Selective Inhibition of CETP Expression by Apo E Peptide in a Human CETP–Stably Transfected CHO Cell Line.

K. Liu, J. Ou, K. Saku, S. Jimi, D. P. Via, J. T. Sparrow, B. Zhang, H. J. Pownall, L. C. Smith, and K. Arakawa (1999)
Arterioscler. Thromb. Vasc. Biol. 19, 2207-2213
 |  Abstract »  |  Full Text »  |  PDF »

Antisense Bcl-2 Oligodeoxynucleotides Inhibit Progression to Androgen-Independence after Castration in the Shionogi Tumor Model.

H. Miyake, A. Tolcher, and M. E. Gleave (1999)
Cancer Res. 59, 4030-4034
 |  Abstract »  |  Full Text »  |  PDF »

Glucocorticoids regulate transendothelial fluid flow resistance and formation of intercellular junctions.

J. L. Underwood, C. G. Murphy, J. Chen, L. Franse-Carman, I. Wood, D. L. Epstein, and J. A. Alvarado (1999)
Am J Physiol Cell Physiol 277, C330-C342
 |  Abstract »  |  Full Text »  |  PDF »

Pressure delivery of AS-ICAM-1 ODN with LFA-1 mAb reduces reperfusion injury in cardiac allografts.

B. T. Feeley, A. K. Park, S. Alexopoulos, E. G. Hoyt, M. P. Ennen, R. S. Poston Jr, and R. C. Robbins (1999)
Ann. Thorac. Surg. 68, 119-124
 |  Abstract »  |  Full Text »  |  PDF »

Interruption of Activin A Autocrine Regulation by Antisense Oligodeoxynucleotides Accelerates Liver Tumor Cell Proliferation.

K. Takabe, J.-J. Lebrun, Y. Nagashima, Y. Ichikawa, M. Mitsuhashi, N. Momiyama, T. Ishikawa, H. Shimada, and W. W. Vale (1999)
Endocrinology 140, 3125-3132
 |  Abstract »  |  Full Text »

Dynamics of phosphorothioate oligonucleotides in normal and laser photocoagulated retina.

W.-Y. Shen, K. L Garrett, L. da Cruz, I. J Constable, and P. E Rakoczy (1999)
Br. J. Ophthalmol. 83, 852-861
 |  Abstract »  |  Full Text »

Suppression of Smooth Muscle Cell Proliferation by a c-myc RNA-cleaving Deoxyribozyme.

L.-Q. Sun, M. J. Cairns, W. L. Gerlach, C. Witherington, L. Wang, and A. King (1999)
J. Biol. Chem. 274, 17236-17241
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Intimal Thickening After Balloon Angioplasty in Porcine Coronary Arteries by Targeting Regulators of the Cell Cycle.

R. Gallo, A. Padurean, T. Jayaraman, S. Marx, M. Roque, S. Adelman, J. Chesebro, J. Fallon, V. Fuster, A. Marks, et al. (1999)
Circulation 99, 2164-2170
 |  Abstract »  |  Full Text »  |  PDF »

The Jun Kinase 2 Isoform Is Preferentially Required for Epidermal Growth Factor-Induced Transformation of Human A549 Lung Carcinoma Cells.

F. Bost, R. McKay, M. Bost, O. Potapova, N. M. Dean, and D. Mercola (1999)
Mol. Cell. Biol. 19, 1938-1949
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of a Potent and Specific Class of Antisense Oligonucleotide Inhibitor of Human Protein Kinase C-alpha Expression.

R. A. McKay, L. J. Miraglia, L. L. Cummins, S. R. Owens, H. Sasmor, and N. M. Dean (1999)
J. Biol. Chem. 274, 1715-1722
 |  Abstract »  |  Full Text »  |  PDF »

Is Gene Therapy for Hypertension Possible?.

M. I. Phillips (1999)
Hypertension 33, 8-13
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Ex vivo gene therapy prevents chronic graft vascular disease incardiac allografts.

R. S. Poston, M. Ennen, J. Pollard, E. G. Hoyt, M. E. Billingham, and R. C. Robbins (1998)
J. Thorac. Cardiovasc. Surg. 116, 386-390
 |  Abstract »  |  Full Text »

Proceedings of the British Toxicology Society Annual Congress University of Surrey, Guildford 19 - 22 April 1998.

(1998)
Human and Experimental Toxicology 17, 469-534
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Nucleic Acid Therapeutics: State of the Art and Future Prospects.

A. M. Gewirtz, D. L. Sokol, and M. Z. Ratajczak (1998)
Blood 92, 712-736
 |  Full Text »  |  PDF »

Potent inhibition of respiratory syncytial virus replication using a 2-5A-antisense chimera targeted to signals within the virus genomic RNA.

M. R. Player, D. L. Barnard, and P. F. Torrence (1998)
PNAS 95, 8874-8879
 |  Abstract »  |  Full Text »  |  PDF »

Novel Chemically Modified Oligonucleotides Provide Potent Inhibition of P-Glycoprotein Expression.

S. K. Alahari, R. DeLong, M. H. Fisher, N. M. Dean, P. Viliet, and R. L. Juliano (1998)
J. Pharmacol. Exp. Ther. 286, 419-428
 |  Abstract »  |  Full Text »

Selective Inhibition of alpha 1B-Adrenergic Receptor Expression and Function Using a Phosphorothioate Antisense Oligodeoxynucleotide.

P. J. Gonzalez-Cabrera, P. L. Iversen, M. F. Liu, M. A. Scofield, and W. B. Jeffries (1998)
Mol. Pharmacol. 53, 1034-1039
 |  Abstract »  |  Full Text »

Inhibition of P-Glycoprotein and Recovery of Drug Sensitivity of Human Acute Leukemic Blast Cells by Multidrug Resistance Gene (mdr1) Antisense Oligonucleotides.

S. Motomura, T. Motoji, M. Takanashi, Y.-H. Wang, H. Shiozaki, I. Sugawara, E. Aikawa, A. Tomida, T. Tsuruo, N. Kanda, et al. (1998)
Blood 91, 3163-3171
 |  Abstract »  |  Full Text »  |  PDF »

Intravenous Injection With Antisense Oligodeoxynucleotides Against Angiotensinogen Decreases Blood Pressure in Spontaneously Hypertensive Rats.

N. Makino, M. Sugano, S. Ohtsuka, and S. Sawada (1998)
Hypertension 31, 1166-1170
 |  Abstract »  |  Full Text »  |  PDF »

Antisense inhibition of the PTI-1 oncogene reverses cancer phenotypes.

Z.-z. Su, N. I. Goldstein, and P. B. Fisher (1998)
PNAS 95, 1764-1769
 |  Abstract »  |  Full Text »  |  PDF »

Liver Uptake of Phosphodiester Oligodeoxynucleotides Is Mediated by Scavenger Receptors.

E. A. L. Biessen, H. Vietsch, J. Kuiper, M. K. Bijsterbosch, and T. J. C. v. Berkel (1998)
Mol. Pharmacol. 53, 262-269
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Oligodeoxyribonucleotide Uptake in Primary Human Hematopoietic Cells Is Enhanced by Cationic Lipids and Depends on the Hematopoietic Cell Subset.

R. Kronenwett, U. Steidl, M. Kirsch, G. Sczakiel, and R. Haas (1998)
Blood 91, 852-862
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Antibody Responses to DNA in Normal Immunity and Aberrant Immunity.

D. S. Pisetsky (1998)
Clin. Vaccine Immunol. 5, 1-6
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Attenuation of Calcitonin Gene Expression in Pregnant Rat Uterus Leads to a Block in Embryonic Implantation.

L.-J. Zhu, M. K. Bagchi, and I. C. Bagchi (1998)
Endocrinology 139, 330-339
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Modulation of Growth Factor Action : Implications for the Treatment of Cardiovascular Diseases.

J. Waltenberger (1997)
Circulation 96, 4083-4094
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Fifty Years of Studies of the Biology and Therapy of Childhood Leukemia.

J. H. Kersey (1997)
Blood 90, 4243-4251
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Advanced Glycation End Product (AGE)–Mediated Induction of Tissue Factor in Cultured Endothelial Cells Is Dependent on RAGE.

A. Bierhaus, T. Illmer, M. Kasper, T. Luther, P. Quehenberger, H. Tritschler, P. Wahl, R. Ziegler, M. Muller, and P. P. Nawroth (1997)
Circulation 96, 2262-2271
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Central Overexpression of the TRH Precursor Gene Induces Hypertension in Rats : Antisense Reversal.

S. I. Garcia, P. I. Porto, A. L. Alvarez, V. N. Martinez, D. Shaurli, S. Finkielman, and C. J. Pirola (1997)
Hypertension 30, 759-766
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The antisense bcl-2-IgH transcript is an optimal target for synthetic oligonucleotides.

S. Morelli, D. Delia, S. Capaccioli, A. Quattrone, N. Schiavone, A. Bevilacqua, S. Tomasini, and A. Nicolin (1997)
PNAS 94, 8150-8155
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An Antisense Oligodeoxynucleotide to Lipocortin 1 Reverses the Inhibitory Actions of Dexamethasone on the Release of Adrenocorticotropin from Rat Pituitary Tissue in Vitro.

A. D. Taylor, H. C. Christian, J. F. Morris, R. J. Flower, and J. C. Buckingham (1997)
Endocrinology 138, 2909-2918
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Antisense Oligodeoxyribonucleotides Suppress Hematologic Cell Growth Through Stepwise Release of Deoxyribonucleotides.

J.L. Vaerman, P. Moureau, F. Deldime, P. Lewalle, C. Lammineur, F. Morschhauser, and P. Martiat (1997)
Blood 90, 331-339
 |  Abstract »  |  Full Text »  |  PDF &r