Science 27 August 1993: Vol. 261. no. 5125, pp. 1171 - 1175 DOI: 10.1126/science.8356451

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Articles

Terminal Deoxynucleotidyltransferase Is Required for the Establishment of Private Virus-Specific CD8+ TCR Repertoires and Facilitates Optimal CTL Responses.

K. Kedzierska, P. G. Thomas, V. Venturi, M. P. Davenport, P. C. Doherty, S. J. Turner, and N. L. La Gruta (2008)
J. Immunol. 181, 2556-2562
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Terminal Deoxynucleotidyl Transferase Establishes and Broadens Antiviral CD8+ T Cell Immunodominance Hierarchies.

S. M. M. Haeryfar, H. D. Hickman, K. R. Irvine, D. C. Tscharke, J. R. Bennink, and J. W. Yewdell (2008)
J. Immunol. 181, 649-659
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BPOZ-2 directly binds to eEF1A1 to promote eEF1A1 ubiquitylation and degradation and prevent translation..

K. Koiwai, S. Maezawa, T. Hayano, M. Iitsuka, and O. Koiwai (2008)
Genes Cells 13, 593-607
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The Mechanism of Human Nonhomologous DNA End Joining.

M. R. Lieber (2008)
J. Biol. Chem. 283, 1-5
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Heterosubtypic Immunity to Influenza A Virus Infection Requires a Properly Diversified Antibody Repertoire.

H. H. Nguyen, M. Zemlin, I. I. Ivanov, J. Andrasi, C. Zemlin, H. L. Vu, R. Schelonka, H. W. Schroeder Jr., and J. Mestecky (2007)
J. Virol. 81, 9331-9338
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Identification of functional domains in TdIF1 and its inhibitory mechanism for TdT activity.

T. Kubota, S. Maezawa, K. Koiwai, T. Hayano, and O. Koiwai (2007)
Genes Cells 12, 941-959
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Processing of DNA for Nonhomologous End-joining Is Controlled by Kinase Activity and XRCC4/Ligase IV.

J. Budman, S. A. Kim, and G. Chu (2007)
J. Biol. Chem. 282, 11950-11959
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T Cell Repertoire Diversity Is Required for Relapses in Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis.

N. Fazilleau, C. Delarasse, I. Motta, S. Fillatreau, M.-L. Gougeon, P. Kourilsky, D. Pham-Dinh, and J. M. Kanellopoulos (2007)
J. Immunol. 178, 4865-4875
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Paucity of V-D-D-J Rearrangements and VH Replacement Events in Lupus Prone and Nonautoimmune TdT-/- and TdT+/+ Mice.

L. C. Watson, C. S. Moffatt-Blue, R. Z. McDonald, E. Kompfner, D. Ait-Azzouzene, D. Nemazee, A. N. Theofilopoulos, D. H. Kono, and A. J. Feeney (2006)
J. Immunol. 177, 1120-1128
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Critical roles of the immunoglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci.

M. A. Inlay, T. Lin, H. H. Gao, and Y. Xu (2006)
J. Exp. Med. 203, 1721-1732
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RAISE: a simple and novel method of generating random insertion and deletion mutations.

R. Fujii, M. Kitaoka, and K. Hayashi (2006)
Nucleic Acids Res. 34, e30
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DNA Joint Dependence of Pol X Family Polymerase Action in Nonhomologous End Joining.

J. M. Daley, R. L. V. Laan, A. Suresh, and T. E. Wilson (2005)
J. Biol. Chem. 280, 29030-29037
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DNA polymerase lambda directly binds to proliferating cell nuclear antigen through its confined C-terminal region.

N. Shimazaki, T. Yazaki, T. Kubota, A. Sato, A. Nakamura, S. Kurei, S. Toji, K. Tamai, and O. Koiwai (2005)
Genes Cells 10, 705-715
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V{alpha} and V{beta} Public Repertoires Are Highly Conserved in Terminal Deoxynucleotidyl Transferase-Deficient Mice.

N. Fazilleau, J.-P. Cabaniols, F. Lemaitre, I. Motta, P. Kourilsky, and J. M. Kanellopoulos (2005)
J. Immunol. 174, 345-355
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Distinct and Opposite Activities of Human Terminal Deoxynucleotidyltransferase Splice Variants.

T.-H. Thai and J. F. Kearney (2004)
J. Immunol. 173, 4009-4019
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Surface {micro} Heavy Chain Signals Down-Regulation of the V(D)J-Recombinase Machinery in the Absence of Surrogate Light Chain Components.

G. R. Galler, C. Mundt, M. Parker, R. Pelanda, I.-L. Martensson, and T. H. Winkler (2004)
J. Exp. Med. 199, 1523-1532
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Involvement of V(D)J recombinase in the generation of intragenic deletions in the Rit1/Bcl11b tumor suppressor gene in {gamma}-ray-induced thymic lymphomas and in normal thymus of the mouse.

J. Sakata, J. Inoue, H. Ohi, H. Kosugi-Okano, Y. Mishima, K. Hatakeyama, O. Niwa, and R. Kominami (2004)
Carcinogenesis 25, 1069-1075
 |  Abstract »  |  Full Text »  |  PDF »

Evidence That the Long Murine Terminal Deoxynucleotidyltransferase Isoform Plays No Role in the Control of V(D)J Junctional Diversity.

N. Doyen, J.-B. Boule, F. Rougeon, and C. Papanicolaou (2004)
J. Immunol. 172, 6764-6767
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In Vitro Processing of the 3'-Overhanging DNA in the Postcleavage Complex Involved in V(D)J Joining.

T. Nishihara, F. Nagawa, H. Nishizumi, M. Kodama, S. Hirose, R. Hayashi, and H. Sakano (2004)
Mol. Cell. Biol. 24, 3692-3702
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Mutational Analysis of Terminal Deoxynucleotidyltransferase- Mediated N-Nucleotide Addition in V(D)J Recombination.

J. A. E. Repasky, E. Corbett, C. Boboila, and D. G. Schatz (2004)
J. Immunol. 172, 5478-5488
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Terminal Deoxynucleotidyltransferase Deficiency Decreases Autoimmune Disease in Diabetes-Prone Nonobese Diabetic Mice and Lupus-Prone MRL-Faslpr Mice.

I. F. Robey, M. Peterson, M. S. Horwitz, D. H. Kono, T. Stratmann, A. N. Theofilopoulos, N. Sarvetnick, L. Teyton, and A. J. Feeney (2004)
J. Immunol. 172, 4624-4629
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A New Model of Sheep Ig Diversification: Shifting the Emphasis Toward Combinatorial Mechanisms and Away from Hypermutation.

C. N. Jenne, L. J. Kennedy, P. McCullagh, and J. D. Reynolds (2003)
J. Immunol. 170, 3739-3750
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Detection of Functional VH81X Heavy Chains in Adult Mice with an Assessment of Complementarity-Determining Region 3 Diversity and Capacity to Form Pre-B Cell Receptor.

T. A. Hayden, P. Riegert, and G. H. Kline (2002)
J. Immunol. 169, 1970-1977
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MaGiK Method of T-Cell Receptor Repertoire Analysis.

M. S. Killian, J. Matud, R. Detels, J. V. Giorgi, and B. D. Jamieson (2002)
Clin. Vaccine Immunol. 9, 858-863
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Most {alpha}/{beta} T Cell Receptor Diversity Is Due to Terminal Deoxynucleotidyl Transferase.

J.-P. Cabaniols, N. Fazilleau, A. Casrouge, P. Kourilsky, and J. M. Kanellopoulos (2001)
J. Exp. Med. 194, 1385-1390
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Promotion of Cell Cycle Progression by Basic Helix-Loop-Helix E2A.

F. Zhao, A. Vilardi, R. J. Neely, and J. K. Choi (2001)
Mol. Cell. Biol. 21, 6346-6357
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Terminal Deoxynucleotidyl Transferase Deficiency Decreases Autoimmune Disease in MRL-Faslpr Mice.

A. J. Feeney, B. R. Lawson, D. H. Kono, and A. N. Theofilopoulos (2001)
J. Immunol. 167, 3486-3493
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Characteristics of early murine B-lymphocyte precursors and their direct sensitivity to negative regulators.

T. Kouro, K. L. Medina, K. Oritani, and P. W. Kincade (2001)
Blood 97, 2708-2715
 |  Abstract »  |  Full Text »  |  PDF »

Ku80 is required for addition of N nucleotides to V(D)J recombination junctions by terminal deoxynucleotidyl transferase.

M. M. Purugganan, S. Shah, J. F. Kearney, and D. B. Roth (2001)
Nucleic Acids Res. 29, 1638-1646
 |  Abstract »  |  Full Text »  |  PDF »

Irradiation Promotes V(D)J Joining and RAG-Dependent Neoplastic Transformation in SCID T-Cell Precursors.

C. J. Williams, I. Grandal, D. J. Vesprini, U. Wojtyra, J. S. Danska, and C. J. Guidos (2001)
Mol. Cell. Biol. 21, 400-413
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Evidence That Terminal Deoxynucleotidyltransferase Expression Plays a Role in Ig Heavy Chain Gene Segment Utilization.

N. Tuaillon and J. D. Capra (2000)
J. Immunol. 164, 6387-6397
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Follicular lymphomas' BCL-2/IgH junctions contain templated nucleotide insertions: novel insights into the mechanism of t(14;18) translocation.

U. Jager, S. Bocskor, T. Le, G. Mitterbauer, I. Bolz, A. Chott, M. Kneba, C. Mannhalter, and B. Nadel (2000)
Blood 95, 3520-3529
 |  Abstract »  |  Full Text »  |  PDF »

Terminal deoxynucleotidyl transferase catalyzes the reaction of DNA phosphorylation.

A. A. Arzumanov, L. S. Victorova, M. V. Jasko, D. S. Yesipov, and A. A. Krayevsky (2000)
Nucleic Acids Res. 28, 1276-1281
 |  Abstract »  |  Full Text »  |  PDF »

Activation of DNA-dependent Protein Kinase by Single-stranded DNA Ends.

O. Hammarsten, L. G. DeFazio, and G. Chu (2000)
J. Biol. Chem. 275, 1541-1550
 |  Abstract »  |  Full Text »  |  PDF »

High-Level Rearrangement and Transcription of Yeast Artificial Chromosome-Based Mouse Ig{kappa} Transgenes Containing Distal Regions of the Contig.

S. Li, R. E. Hammer, J. B. George-Raizen, K. C. Meyers, and W. T. Garrard (2000)
J. Immunol. 164, 812-824
 |  Abstract »  |  Full Text »  |  PDF »

The Interplay between Nonhomologous End-joining and Cell Cycle Checkpoint Factors in Development, Genomic Stability, and Tumorigenesis.

D.O. FERGUSON, J.M. SEKIGUCHI, K.M. FRANK, Y. GAO, N.E. SHARPLESS, Y. GU, J. MANIS, R.A. DEPINHO, and F.W. ALT (2000)
Cold Spring Harb Symp Quant Biol 65, 395-404
 |  Abstract »  |  PDF »

Modulation of Terminal Deoxynucleotidyltransferase Activity by the DNA-Dependent Protein Kinase.

S. Mickelsen, C. Snyder, K. Trujillo, M. Bogue, D. B. Roth, and K. Meek (1999)
J. Immunol. 163, 834-843
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Unexpected Rearrangement and Expression of the Immunoglobulin {lambda}1 Locus in Scid Mice.

N. R. Ruetsch, G. C. Bosma, and M. J. Bosma (1999)
J. Exp. Med. 191, 1933-1944
 |  Abstract »  |  Full Text »  |  PDF »

DNA Hairpin Opening Mediated by the RAG1 and RAG2 Proteins.

P. E. Shockett and D. G. Schatz (1999)
Mol. Cell. Biol. 19, 4159-4166
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Evidence That the Ig{kappa} Gene MAR Regulates the Probability of Premature V-J Joining and Somatic Hypermutation.

M. Yi, P. Wu, K. W. Trevorrow, L. Claflin, and W. T. Garrard (1999)
J. Immunol. 162, 6029-6039
 |  Abstract »  |  Full Text »  |  PDF »

Extensive Junctional Diversity in Ig Light Chain Genes from Early B Cell Progenitors of {micro}MT Mice.

L. A. Bentolila, S. Olson, A. Marshall, F. Rougeon, C. J. Paige, N. Doyen, and G. E. Wu (1999)
J. Immunol. 162, 2123-2128
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Mechanisms of Transcriptional Regulation in Lymphocyte Progenitors: Insight from an Analysis of the Terminal Transferase Promoter.

P. ERNST, K. HAHM, B. S. COBB, K. E. BROWN, L.A. TRINH, A.S. MCCARTY, M. MERKENSCHLAGER, C.A. KLUG, A.G. FISHER, and S.T. SMALE (1999)
Cold Spring Harb Symp Quant Biol 64, 87-98
 |  Abstract »  |  PDF »

Nonhomologous End-joining Proteins Are Required for V(D)J Recombination, Normal Growth, and Neurogenesis.

J.M. SEKIGUCHI, Y. GAO, Y. GU, K. FRANK, Y. SUN, J. CHAUDHURI, C. ZHU, H.-L. CHENG, J. MANIS, D. FERGUSON, et al. (1999)
Cold Spring Harb Symp Quant Biol 64, 169-182
 |  Abstract »  |  PDF »

Terminal Deoxynucleotidyl Transferase Expression During Neonatal Life Alters DH Reading Frame Usage and Ig-Receptor-Dependent Selection of V Regions.

A. J. Marshall, N. Doyen, L. A. Bentolila, C. J. Paige, and G. E. Wu (1998)
J. Immunol. 161, 6657-6663
 |  Abstract »  |  Full Text »  |  PDF »

Terminal Deoxynucleotidyl Transferase Deficiency Reduces the Incidence of Autoimmune Nephritis in (New Zealand Black New Zealand White)F1 Mice.

C. Conde, S. Weller, S. Gilfillan, L. Marcellin, T. Martin, and J.-L. Pasquali (1998)
J. Immunol. 161, 7023-7030
 |  Abstract »  |  Full Text »  |  PDF »

Somatic Mutation in the Neonatal Mouse.

C. A. Giorgetti and J. L. Press (1998)
J. Immunol. 161, 6093-6104
 |  Abstract »  |  Full Text »  |  PDF »

Antigen Receptor Engagement Turns off the V(D)J Recombination Machinery in Human Tonsil B Cells.

E. Meffre, F. Papavasiliou, P. Cohen, O. de Bouteiller, D. Bell, H. Karasuyama, C. Schiff, J. Banchereau, Y.-J. Liu, and M. C. Nussenzweig (1998)
J. Exp. Med. 188, 765-772
 |  Abstract »  |  Full Text »  |  PDF »

Targeted Inactivation of the Coagulation Factor IX Gene Causes Hemophilia B in Mice.

R. K. Kundu, F. Sangiorgi, L.-Y. Wu, K. Kurachi, W. F. Anderson, R. Maxson, and E. M. Gordon (1998)
Blood 92, 168-174
 |  Abstract »  |  Full Text »  |  PDF »

Rearrangement and Selection in the Developing V{kappa} Repertoire of the Mouse: An Analysis of the Usage of Two V{kappa} Gene Segments.

E. A. Whitcomb and P. H. Brodeur (1998)
J. Immunol. 160, 4904-4913
 |  Abstract »  |  Full Text »  |  PDF »

Extensive Junctional Diversity of Ig Heavy Chain Rearrangements Generated in the Progeny of Single Fetal Multipotent Hematopoietic Cells in the Absence of Selection.

F. Nourrit, N. Doyen, P. Kourilsky, F. Rougeon, and A. Cumano (1998)
J. Immunol. 160, 4254-4261
 |  Abstract »  |  Full Text »  |  PDF »

Ontogeny of the Heavy Chain Immunoglobulin Repertoire in Fetal Liver and Bone Marrow.

S. Delassus, S. Darche, P. Kourilsky, and A. Cumano (1998)
J. Immunol. 160, 3274-3280
 |  Abstract »  |  Full Text »  |  PDF »

Use of D gene segments with irregular spacers in terminal deoxynucleotidyltransferase (TdT)+/+ and TdT-/- mice carrying a human Ig heavy chain transgenic minilocus.

N. Tuaillon and J. D. Capra (1998)
PNAS 95, 1703-1708
 |  Abstract »  |  Full Text »  |  PDF »

Mycoplasma Superantigen Is a CDR3-dependent Ligand for the T Cell Antigen Receptor.

A. S. Hodtsev, Y. Choi, E. Spanopoulou, and D. N. Posnett (1998)
J. Exp. Med. 187, 319-327
 |  Abstract »  |  Full Text »  |  PDF »

Footprint Analysis of the RAG Protein Recombination Signal Sequence Complex for V(D)J Type Recombination.

F. Nagawa, K.-i. Ishiguro, A. Tsuboi, T. Yoshida, A. Ishikawa, T. Takemori, A. J. Otsuka, and H. Sakano (1998)
Mol. Cell. Biol. 18, 655-663
 |  Abstract »  |  Full Text »

Double Strand Break Repair.

G. Chu (1997)
J. Biol. Chem. 272, 24097-24100
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Point mutations at the purine nucleoside phosphorylase locus impair thymocyte differentiation in the mouse.

F. F. Snyder, J. P. Jenuth, E. R. Mably, and R. K. Mangat (1997)
PNAS 94, 2522-2527
 |  Abstract »  |  Full Text »  |  PDF »

In vitro V(D)J recombination: Signal joint formation.

P. Cortes, F. Weis-Garcia, Z. Misulovin, A. Nussenzweig, J.-S. Lai, G. Li, M. C. Nussenzweig, and D. Baltimore (1996)
PNAS 93, 14008-14013
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of Defective DNA Transfer Activity in Recombination Deficient SCID Cell Extracts by a 72-kDa Protein from Wild-type Thymocytes.

R. Jessberger, B. Riwar, A. Rolink, and H.-R. Rodewald (1995)
J. Biol. Chem. 270, 6788-6797
 |  Abstract »  |  Full Text »  |  PDF »

Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line.

S. Lees-Miller, R Godbout, D. Chan, M Weinfeld, R. Day 3rd, G. Barron, and J Allalunis-Turner (1995)
Science 267, 1183-1185
 |  Abstract »  |  PDF »

Rescue of T cell-specific V(D)J recombination in SCID mice by DNA-damaging agents.

J. Danska, F Pflumio, C. Williams, O Huner, J. Dick, and C. Guidos (1994)
Science 266, 450-455
 |  Abstract »  |  PDF »

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice..

E Spanopoulou, C A Roman, L M Corcoran, M S Schlissel, D P Silver, D Nemazee, M C Nussenzweig, S A Shinton, R R Hardy, and D Baltimore (1994)
Genes & Dev. 8, 1030-1042
 |  Abstract »  |  PDF »

Mice lacking TdT: mature animals with an immature lymphocyte repertoire.

S Gilfillan, A Dierich, M Lemeur, C Benoist, and D Mathis (1993)
Science 261, 1175-1178
 |  Abstract »  |  PDF »

Comparison of the Two Murine Deoxynucleotidyltransferase Terminal Isoforms. A 20-AMINO ACID INSERTION IN THE HIGHLY CONSERVED CARBOXYL-TERMINAL REGION MODIFIES THE THERMOSENSITIVITY BUT NOT THE CATALYTIC ACTIVITY.

J.-B. Boule, F. Rougeon, and C. Papanicolaou (2000)
J. Biol. Chem. 275, 28984-28988
 |  Abstract »  |  Full Text »  |  PDF »

Terminal Deoxynucleotidyl Transferase Indiscriminately Incorporates Ribonucleotides and Deoxyribonucleotides.

J.-B. Boule, F. Rougeon, and C. Papanicolaou (2001)
J. Biol. Chem. 276, 31388-31393
 |  Abstract »  |  Full Text »  |  PDF »

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