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Science 5 August 1994:
Vol. 265. no. 5173, pp. 785 - 789
DOI: 10.1126/science.7914031
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Articles

Science, Vol 265, Issue 5173, 785-789
Copyright © 1994 by American Association for the Advancement of Science

articles

Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans

R Quiring, U Walldorf, U Kloter, and WJ Gehring

Department of Cell Biology, University of Basel, Switzerland.

A Drosophila gene that contains both a paired box and a homeobox and has extensive sequence homology to the mouse Pax-6 (Small eye) gene was isolated and mapped to chromosome IV in a region close to the eyeless locus. Two spontaneous mutations, ey2 and eyR, contain transposable element insertions into the cloned gene and affect gene expression, particularly in the eye primordia. This indicates that the cloned gene encodes ey. The finding that ey of Drosophila, Small eye of the mouse, and human Aniridia are encoded by homologous genes suggests that eye morphogenesis is under similar genetic control in both vertebrates and insects, in spite of the large differences in eye morphology and mode of development.


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Control of Drosophila eye specification by Wingless signalling.
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Development 129, 1143-1154
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Differential interactions of eyeless and twin of eyeless with the sine oculis enhancer.
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PAX6 Mutation as a Genetic Factor Common to Aniridia and Glucose Intolerance.
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Development 128, 4415-4424
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Isolation and characterization of a downstream target of Pax6 in the mammalian retinal primordium.
G. Bernier, W. Vukovich, L. Neidhardt, B. G. Herrmann, and P. Gruss (2001)
Development 128, 3987-3994
   Abstract »    Full Text »    PDF »
Medaka eyeless is the key factor linking retinal determination and eye growth.
F. Loosli, S. Winkler, C. Burgtorf, E. Wurmbach, W. Ansorge, T. Henrich, C. Grabher, D. Arendt, M. Carl, A. Krone, et al. (2001)
Development 128, 4035-4044
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Headless flies generated by developmental pathway interference.
R. Jiao, M. Daube, H. Duan, Y. Zou, E. Frei, and M. Noll (2001)
Development 128, 3307-3319
   Abstract »    Full Text »    PDF »
The eyeless homeodomain is dispensable for eye development in Drosophila.
C. Punzo, S. Kurata, and W. J. Gehring (2001)
Genes & Dev. 15, 1716-1723
   Abstract »    Full Text »    PDF »
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Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6.
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Development 128, 779-790
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Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development.
J Treisman (2001)
Development 128, 603-615
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Homology in Development and the Development of the Homology Concept.
M. D. Laubichler (2000)
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Molecular Analysis of Drosophila eyes absent Mutants Reveals Features of the Conserved Eya Domain.
Q. T. Bui, J. E. Zimmerman, H. Liu, and N. M. Bonini (2000)
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D. Pineda, J. Gonzalez, P. Callaerts, K. Ikeo, W. J. Gehring, and E. Salo (2000)
PNAS 97, 4525-4529
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Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6.
M Schwarz, F Cecconi, G Bernier, N Andrejewski, B Kammandel, M Wagner, and P Gruss (2000)
Development 127, 4325-4334
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Early development of the Drosophila mushroom body: the roles of eyeless and dachshund.
A Noveen, A Daniel, and V Hartenstein (2000)
Development 127, 3475-3488
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FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development.
H. Makarenkova, M Ito, V Govindarajan, S. Faber, L Sun, G McMahon, P. Overbeek, and R. Lang (2000)
Development 127, 2563-2572
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The retinal determination gene, dachshund, is required for mushroom body cell differentiation.
S. Martini, G Roman, S Meuser, G Mardon, and R. Davis (2000)
Development 127, 2663-2672
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The Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism.
M Seimiya and W. Gehring (2000)
Development 127, 1879-1886
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The conditional medaka mutation eyeless uncouples patterning and morphogenesis of the eye.
S Winkler, F Loosli, T Henrich, Y Wakamatsu, and J Wittbrodt (2000)
Development 127, 1911-1919
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Transcriptional regulation of atonal required for Drosophila larval eye development by concerted action of eyes absent, sine oculis and hedgehog signaling independent of fused kinase and cubitus interruptus.
T Suzuki and K Saigo (2000)
Development 127, 1531-1540
   Abstract »    PDF »
pannier acts upstream of wingless to direct dorsal eye disc development in Drosophila.
C Maurel-Zaffran and J. Treisman (2000)
Development 127, 1007-1016
   Abstract »    PDF »
Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent.
J Curtiss and M Mlodzik (2000)
Development 127, 1325-1336
   Abstract »    PDF »
Molecular Genetic Analysis of Drosophila eyes absent Mutants Reveals an Eye Enhancer Element.
J. E. Zimmerman, Q. T. Bui, H. Liu, and N. M. Bonini (2000)
Genetics 154, 237-246
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Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation.
T. A. Heanue, R. Reshef, R. J. Davis, G. Mardon, G. Oliver, S. Tomarev, A. B. Lassar, and C. J. Tabin (1999)
Genes & Dev. 13, 3231-3243
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Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway.
D. C.I. Goberdhan, N. Paricio, E. C. Goodman, M. Mlodzik, and C. Wilson (1999)
Genes & Dev. 13, 3244-3258
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A homeobox gene, vax2, controls the patterning of the eye dorsoventral axis.
A. M. Barbieri, G. Lupo, A. Bulfone, M. Andreazzoli, M. Mariani, F. Fougerousse, G. G. Consalez, G. Borsani, J. S. Beckmann, G. Barsacchi, et al. (1999)
PNAS 96, 10729-10734
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Regional Expression of the Rice KN1-Type Homeobox Gene Family during Embryo, Shoot, and Flower Development.
N. Sentoku, Y. Sato, N. Kurata, Y. Ito, H. Kitano, and M. Matsuoka (1999)
PLANT CELL 11, 1651-1664
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Regulation of Prox 1 during Lens Regeneration.
K. Del Rio-Tsonis, S. I. Tomarev, and P. A. Tsonis (1999)
Invest. Ophthalmol. Vis. Sci. 40, 2039-2045
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A Genetic Method for Generating Drosophila Eyes Composed Exclusively of Mitotic Clones of a Single Genotype.
R. S. Stowers and T. L. Schwarz (1999)
Genetics 152, 1631-1639
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Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding.
H. E. Xu, M. A. Rould, W. Xu, J. A. Epstein, R. L. Maas, and C. O. Pabo (1999)
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