Science 26 August 1994: Vol. 265. no. 5176, pp. 1243 - 1246 DOI: 10.1126/science.8066465

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Articles

ATR-dependent Activation of p38 MAP Kinase Is Responsible for Apoptotic Cell Death in Cells Depleted of Cdc7.

J.-S. Im and J.-K. Lee (2008)
J. Biol. Chem. 283, 25171-25177
 |  Abstract »  |  Full Text »  |  PDF »

One step construction of PCR mutagenized libraries for genetic analysis by recombination cloning.

A.-M. Khalil, J. A. Julius, and J. Bachant (2007)
Nucleic Acids Res.
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms Regulating the Protein Kinases of Saccharomyces cerevisiae.

E. M. Rubenstein and M. C. Schmidt (2007)
Eukaryot. Cell 6, 571-583
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Novel Role for Checkpoint Rad53 Protein Kinase in the Initiation of Chromosomal DNA Replication in Saccharomyces cerevisiae.

P. R. Dohrmann and R. A. Sclafani (2006)
Genetics 174, 87-99
 |  Abstract »  |  Full Text »  |  PDF »

A Dbf4p BRCA1 C-Terminal-Like Domain Required for the Response to Replication Fork Arrest in Budding Yeast.

C. Gabrielse, C. T. Miller, K. H. McConnell, A. DeWard, C. A. Fox, and M. Weinreich (2006)
Genetics 173, 541-555
 |  Abstract »  |  Full Text »  |  PDF »

Dual Role of the Cdc7-regulatory Protein Dbf4 during Yeast Meiosis.

G. Valentin, E. Schwob, and F. D. Seta (2006)
J. Biol. Chem. 281, 2828-2834
 |  Abstract »  |  Full Text »  |  PDF »

Functional analyses of mouse ASK, an activation subunit for Cdc7 kinase, using conditional ASK knockout ES cells.

N. Yamashita, J.-M. Kim, O. Koiwai, K.-i. Arai, and H. Masai (2005)
Genes Cells 10, 551-563
 |  Abstract »  |  Full Text »  |  PDF »

Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2.

M. Thomer, N. R. May, B. D. Aggarwal, G. Kwok, and B. R. Calvi (2004)
Development 131, 4807-4818
 |  Abstract »  |  Full Text »  |  PDF »

Eukaryotic MCM Proteins: Beyond Replication Initiation.

S. L. Forsburg (2004)
Microbiol. Mol. Biol. Rev. 68, 109-131
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Characterization of a Xenopus Homolog of Dbf4, a Regulatory Subunit of the Cdc7 Protein Kinase Required for the Initiation of DNA Replication.

A. Furukohri, N. Sato, H. Masai, K.-i. Arai, A. Sugino, and S. Waga (2003)
J. Biochem. 134, 447-457
 |  Abstract »  |  Full Text »  |  PDF »

An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing.

B. P. Duncker, K. Shimada, M. Tsai-Pflugfelder, P. Pasero, and S. M. Gasser (2002)
PNAS 99, 16087-16092
 |  Abstract »  |  Full Text »  |  PDF »

A Conserved Domain of Schizosaccharomyces pombe dfp1+ Is Uniquely Required for Chromosome Stability following Alkylation Damage during S Phase.

A. D. Fung, J. Ou, S. Bueler, and G. W. Brown (2002)
Mol. Cell. Biol. 22, 4477-4490
 |  Abstract »  |  Full Text »  |  PDF »

Scheduled Conversion of Replication Complex Architecture at Replication Origins of Saccharomyces cerevisiae during the Cell Cycle.

R. Tadokoro, M. Fujita, H. Miura, K. Shirahige, H. Yoshikawa, T. Tsurimoto, and C. Obuse (2002)
J. Biol. Chem. 277, 15881-15889
 |  Abstract »  |  Full Text »  |  PDF »

The origin recognition complex: from simple origins to complex functions.

S. P. Bell (2002)
Genes & Dev. 16, 659-672
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Novel Fission Yeast Cdc7-Dbf4-Like Kinase Complex Required for the Initiation and Progression of Meiotic Second Division.

T. Nakamura, M. Nakamura-Kubo, T. Nakamura, and C. Shimoda (2002)
Mol. Cell. Biol. 22, 309-320
 |  Abstract »  |  Full Text »  |  PDF »

Control of DNA Rereplication via Cdc2 Phosphorylation Sites in the Origin Recognition Complex.

A. Vas, W. Mok, and J. Leatherwood (2001)
Mol. Cell. Biol. 21, 5767-5777
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Initiation of S Phase, Replication Checkpoint Signaling, and Maintenance of Mitotic Chromosome Structures during S Phase by Hsk1 Kinase in the Fission Yeast.

T. Takeda, K. Ogino, K. Tatebayashi, H. Ikeda, K.-i. Arai, and H. Masai (2001)
Mol. Biol. Cell 12, 1257-1274
 |  Abstract »  |  Full Text »

Functionally distinct, sequence-specific replicator and origin elements are required for Drosophila chorion gene amplification.

L. Lu, H. Zhang, and J. Tower (2001)
Genes & Dev. 15, 134-146
 |  Abstract »  |  Full Text »

Initiating DNA synthesis: from recruiting to activating the MCM complex.

M Lei and B. Tye (2001)
J. Cell Sci. 114, 1447-1454
 |  Abstract »  |  PDF »

Xenopus Cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading.

P. Jares and J. J. Blow (2000)
Genes & Dev. 14, 1528-1540
 |  Abstract »  |  Full Text »

Hierarchy of S-Phase-Promoting Factors: Yeast Dbf4-Cdc7 Kinase Requires Prior S-Phase Cyclin-Dependent Kinase Activation.

R. Nougarède, F. Della Seta, P. Zarzov, and E. Schwob (2000)
Mol. Cell. Biol. 20, 3795-3806
 |  Abstract »  |  Full Text »

Distinct Phosphoisoforms of the Xenopus Mcm4 Protein Regulate the Function of the Mcm Complex.

I. Pereverzeva, E. Whitmire, B. Khan, and M. Coué (2000)
Mol. Cell. Biol. 20, 3667-3676
 |  Abstract »  |  Full Text »

The Stability of the Cdc6 Protein Is Regulated by Cyclin-dependent Kinase/Cyclin B Complexes in Saccharomyces cerevisiae.

A. Calzada, M. Sanchez, E. Sanchez, and A. Bueno (2000)
J. Biol. Chem. 275, 9734-9741
 |  Abstract »  |  Full Text »  |  PDF »

Cdc7p-Dbf4p becomes famous in the cell cycle.

R. Sclafani (2000)
J. Cell Sci. 113, 2111-2117
 |  Abstract »  |  PDF »

Dbf4p, an Essential S Phase-Promoting Factor, Is Targeted for Degradation by the Anaphase-Promoting Complex.

M. Godinho Ferreira, C. Santocanale, L. S. Drury, and J. F. X. Diffley (2000)
Mol. Cell. Biol. 20, 242-248
 |  Abstract »  |  Full Text »

A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication.

P. Pasero, B. P. Duncker, E. Schwob, and S. M. Gasser (1999)
Genes & Dev. 13, 2159-2176
 |  Abstract »  |  Full Text »

A Fission Yeast Gene, him1+/dfp1+, Encoding a Regulatory Subunit for Hsk1 Kinase, Plays Essential Roles in S-Phase Initiation as Well as in S-Phase Checkpoint Control and Recovery from DNA Damage.

T. Takeda, K. Ogino, E. Matsui, M. K. Cho, H. Kumagai, T. Miyake, K.-i. Arai, and H. Masai (1999)
Mol. Cell. Biol. 19, 5535-5547
 |  Abstract »  |  Full Text »  |  PDF »

Cell cycle regulation of Dfp1, an activator of the Hsk1 protein kinase.

G. W. Brown and T. J. Kelly (1999)
PNAS 96, 8443-8448
 |  Abstract »  |  Full Text »  |  PDF »

Cell Cycle Control of Cdc7p Kinase Activity through Regulation of Dbf4p Stability.

G. Oshiro, J. C. Owens, Y. Shellman, R. A. Sclafani, and J. J. Li (1999)
Mol. Cell. Biol. 19, 4888-4896
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Growth- and Cell Cycle-Regulated Protein, ASK, Activates Human Cdc7-Related Kinase and Is Essential for G1/S Transition in Mammalian Cells.

H. Kumagai, N. Sato, M. Yamada, D. Mahony, W. Seghezzi, E. Lees, K.-I. Arai, and H. Masai (1999)
Mol. Cell. Biol. 19, 5083-5095
 |  Abstract »  |  Full Text »  |  PDF »

Cell Cycle Regulation of DNA Replication Initiator Factor Dbf4p.

L. Cheng, T. Collyer, and C. F. J. Hardy (1999)
Mol. Cell. Biol. 19, 4270-4278
 |  Abstract »  |  Full Text »  |  PDF »

RAD53 Regulates DBF4 Independently of Checkpoint Function in Saccharomyces cerevisiae.

P. R. Dohrmann, G. Oshiro, M. Tecklenburg, and R. A. Sclafani (1999)
Genetics 151, 965-977
 |  Abstract »  |  Full Text »

Functionally homologous DNA replication genes in fission and budding yeast.

M Sanchez, A Calzada, and A Bueno (1999)
J. Cell Sci. 112, 2381-2390
 |  Abstract »  |  PDF »

nimO, an Aspergillus gene related to budding yeast Dbf4, is required for DNA synthesis and mitotic checkpoint control.

S. James, K. Bullock, S. Gygax, B. Kraynack, R. Matura, J. MacLeod, K. McNeal, K. Prasauckas, P. Scacheri, H. Shenefiel, et al. (1999)
J. Cell Sci. 112, 1313-1324
 |  Abstract »  |  PDF »

Identification of a Novel MCM3-associated Protein that Facilitates MCM3 Nuclear Localization.

Y. Takei and G. Tsujimoto (1998)
J. Biol. Chem. 273, 22177-22180
 |  Abstract »  |  Full Text »  |  PDF »

Purification of Hsk1, a Minichromosome Maintenance Protein Kinase from Fission Yeast.

G. W. Brown and T. J. Kelly (1998)
J. Biol. Chem. 273, 22083-22090
 |  Abstract »  |  Full Text »  |  PDF »

The Cdc7 protein kinase is required for origin firing during S phase.

K. Bousset and J. F.X. Diffley (1998)
Genes & Dev. 12, 480-490
 |  Abstract »  |  Full Text »

Cdc7 is required throughout the yeast S phasetoactivatereplication origins.

A. D. Donaldson, W. L. Fangman, and B. J. Brewer (1998)
Genes & Dev. 12, 491-501
 |  Abstract »  |  Full Text »

Identification of a Preinitiation Step in DNA Replication That Is Independent of Origin Recognition Complex and cdc6, but Dependent on cdk2.

X. H. Hua and J. Newport (1998)
J. Cell Biol. 140, 271-281
 |  Abstract »  |  Full Text »  |  PDF »

Identification and characterization of a human protein kinase related to budding yeast Cdc7p.

W. Jiang and T. Hunter (1997)
PNAS 94, 14320-14325
 |  Abstract »  |  Full Text »  |  PDF »

Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis.

M. Lei, Y. Kawasaki, M. R. Young, M. Kihara, A. Sugino, and B. K. Tye (1997)
Genes & Dev. 11, 3365-3374
 |  Abstract »  |  Full Text »  |  PDF »

CDC45 is required in conjunction with CDC7/DBF4 to trigger the initiation of DNA replication.

J. C. Owens, C. S. Detweiler, and J. J. Li (1997)
PNAS 94, 12521-12526
 |  Abstract »  |  Full Text »  |  PDF »

mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p.

C. F. J. Hardy, O. Dryga, S. Seematter, P. M. B. Pahl, and R. A. Sclafani (1997)
PNAS 94, 3151-3155
 |  Abstract »  |  Full Text »  |  PDF »

Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells..

J F Diffley (1996)
Genes & Dev. 10, 2819-2830
 |  PDF »

Human Cdc7-related Kinase Complex. IN VITRO PHOSPHORYLATION OF MCM BY CONCERTED ACTIONS OF Cdks AND Cdc7 AND THAT OF A CRITICAL THREONINE RESIDUE OF Cdc7 BY Cdks.

H. Masai, E. Matsui, Z. You, Y. Ishimi, K. Tamai, and K.-i. Arai (2000)
J. Biol. Chem. 275, 29042-29052
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Yeast Cdc7p/Dbf4p Complex Purified from Insect Cells. ITS PROTEIN KINASE ACTIVITY IS REGULATED BY Rad53p.

M. Kihara, W. Nakai, S. Asano, A. Suzuki, K. Kitada, Y. Kawasaki, L. H. Johnston, and A. Sugino (2000)
J. Biol. Chem. 275, 35051-35062
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for Sequential Action of cdc7 and cdk2 Protein Kinases during Initiation of DNA Replication in Xenopus Egg Extracts.

J. C. Walter (2000)
J. Biol. Chem. 275, 39773-39778
 |  Abstract »  |  Full Text »  |  PDF »

Bipartite Binding of a Kinase Activator Activates Cdc7-related Kinase Essential for S Phase.

K. Ogino, T. Takeda, E. Matsui, H. Iiyama, C. Taniyama, K.-i. Arai, and H. Masai (2001)
J. Biol. Chem. 276, 31376-31387
 |  Abstract »  |  Full Text »  |  PDF »

Premature Structural Changes at Replication Origins in a Yeast Minichromosome Maintenance (MCM) Mutant.

D. S. Geraghty, M. Ding, N. H. Heintz, and D. S. Pederson (2000)
J. Biol. Chem. 275, 18011-18021
 |  Abstract »  |  Full Text »  |  PDF »

Synthetic promoter elements obtained by nucleotide sequence variation and selection for activity.

G. M. Edelman, R. Meech, G. C. Owens, and F. S. Jones (2000)
PNAS 97, 3038-3043
 |  Abstract »  |  Full Text »  |  PDF »

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