Science 11 November 1994: Vol. 266. no. 5187, pp. 1045 - 1047 DOI: 10.1126/science.7973659

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Articles

Kaempferol Inhibits IL-4-Induced STAT6 Activation by Specifically Targeting JAK3.

J. R. Cortes, M. Perez-G, M. D. Rivas, and J. Zamorano (2007)
J. Immunol. 179, 3881-3887
 |  Abstract »  |  Full Text »  |  PDF »

Activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment.

C.-L. Hsu, K. Kikuchi, and M. Kondo (2007)
Blood 110, 1420-1428
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Lipid Rafts by {Omega}-3 Fatty Acids in Inflammation and Cancer: Implications for Use of Lipids During Nutrition Support.

R. A. Siddiqui, K. A. Harvey, G. P. Zaloga, and W. Stillwell (2007)
Nutr Clin Pract 22, 74-88
 |  Abstract »  |  Full Text »  |  PDF »

Murine Mammary Carcinoma Exosomes Promote Tumor Growth by Suppression of NK Cell Function.

C. Liu, S. Yu, K. Zinn, J. Wang, L. Zhang, Y. Jia, J. C. Kappes, S. Barnes, R. P. Kimberly, W. E. Grizzle, et al. (2006)
J. Immunol. 176, 1375-1385
 |  Abstract »  |  Full Text »  |  PDF »

Progesterone-Induced Blocking Factor Activates STAT6 via Binding to a Novel IL-4 Receptor.

N. Kozma, M. Halasz, B. Polgar, T. G. Poehlmann, U. R. Markert, T. Palkovics, M. Keszei, G. Par, K. Kiss, J. Szeberenyi, et al. (2006)
J. Immunol. 176, 819-826
 |  Abstract »  |  Full Text »  |  PDF »

Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts.

Q. Li, M. Wang, L. Tan, C. Wang, J. Ma, N. Li, Y. Li, G. Xu, and J. Li (2005)
J. Lipid Res. 46, 1904-1913
 |  Abstract »  |  Full Text »  |  PDF »

Aberrant Stat3 Signaling by Interleukin-4 in Malignant Glioma Cells: Involvement of IL-13R{alpha}2.

S. O. Rahaman, M. A. Vogelbaum, and S. J. Haque (2005)
Cancer Res. 65, 2956-2963
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-2-induced survival of natural killer (NK) cells involving phosphatidylinositol-3 kinase-dependent reduction of ceramide through acid sphingomyelinase, sphingomyelin synthase, and glucosylceramide synthase.

Y. Taguchi, T. Kondo, M. Watanabe, M. Miyaji, H. Umehara, Y. Kozutsumi, and T. Okazaki (2004)
Blood 104, 3285-3293
 |  Abstract »  |  Full Text »  |  PDF »

Targeting the Jak/STAT pathway for immunosuppression.

J J O'Shea (2004)
Ann Rheum Dis 63, ii67-ii71
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Interleukin-7 and Transforming Growth Factor-{beta} Play Counter-regulatory Roles in Protein Kinase C-{delta}-dependent Control of Fibroblast Collagen Synthesis in Pulmonary Fibrosis.

L. Zhang, M. P. Keane, L. X. Zhu, S. Sharma, E. Rozengurt, R. M. Strieter, S. M. Dubinett, and M. Huang (2004)
J. Biol. Chem. 279, 28315-28319
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-13 Induction of 15-Lipoxygenase Gene Expression Requires p38 Mitogen-Activated Protein Kinase-Mediated Serine 727 Phosphorylation of Stat1 and Stat3.

B. Xu, A. Bhattacharjee, B. Roy, H.-M. Xu, D. Anthony, D. A. Frank, G. M. Feldman, and M. K. Cathcart (2003)
Mol. Cell. Biol. 23, 3918-3928
 |  Abstract »  |  Full Text »  |  PDF »

Interleukins in Atherosclerosis: Molecular Pathways and Therapeutic Potential.

J. H. Von der Thusen, J. Kuiper, T. J. C. Van Berkel, and E. A. L. Biessen (2003)
Pharmacol. Rev. 55, 133-166
 |  Abstract »  |  Full Text »  |  PDF »

Contribution of the Box 1 and Box 2 Motifs of Cytokine Receptors to Jak1 Association and Activation.

A. Usacheva, R. Sandoval, P. Domanski, S. V. Kotenko, K. Nelms, M. A. Goldsmith, and O. R. Colamonici (2002)
J. Biol. Chem. 277, 48220-48226
 |  Abstract »  |  Full Text »  |  PDF »

The Pseudokinase Domain Is Required for Suppression of Basal Activity of Jak2 and Jak3 Tyrosine Kinases and for Cytokine-inducible Activation of Signal Transduction.

P. Saharinen and O. Silvennoinen (2002)
J. Biol. Chem. 277, 47954-47963
 |  Abstract »  |  Full Text »  |  PDF »

Enforced Expression of Bcl-2 Restores the Number of NK Cells, But Does Not Rescue the Impaired Development of NKT Cells or Intraepithelial Lymphocytes, in IL-2/IL-15 Receptor {beta}-Chain-Deficient Mice.

M. Minagawa, H. Watanabe, C. Miyaji, K. Tomiyama, H. Shimura, A. Ito, M. Ito, J. Domen, I. L. Weissman, and K. Kawai (2002)
J. Immunol. 169, 4153-4160
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Jak3 pathway is associated with granulocytic differentiation of myeloid precursor cells.

S. G. Rane, J. K. Mangan, A. Amanullah, B. C. Wong, R. K. Vora, D. A. Liebermann, B. Hoffman, X. Grana, and E. P. Reddy (2002)
Blood 100, 2753-2762
 |  Abstract »  |  Full Text »  |  PDF »

IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats.

B. Roy, A. Bhattacharjee, B. Xu, D. Ford, A. L. Maizel, and M. K. Cathcart (2002)
J. Leukoc. Biol. 72, 580-589
 |  Abstract »  |  Full Text »  |  PDF »

Two Distinct Domains Within the N-Terminal Region of Janus Kinase 1 Interact with Cytokine Receptors.

A. Usacheva, S. Kotenko, M. M. Witte, and O. R. Colamonici (2002)
J. Immunol. 169, 1302-1308
 |  Abstract »  |  Full Text »  |  PDF »

Positive Effects of Glucocorticoids on T Cell Function by Up-Regulation of IL-7 Receptor {alpha}.

D. Franchimont, J. Galon, M. S. Vacchio, S. Fan, R. Visconti, D. M. Frucht, V. Geenen, G. P. Chrousos, J. D. Ashwell, and J. J. O'Shea (2002)
J. Immunol. 168, 2212-2218
 |  Abstract »  |  Full Text »  |  PDF »

IL-13R{alpha}2, a Decoy Receptor for IL-13 Acts As an Inhibitor of IL-4-dependent Signal Transduction in Glioblastoma Cells.

S. O. Rahaman, P. Sharma, P. C. Harbor, M. J. Aman, M. A. Vogelbaum, and S. J. Haque (2002)
Cancer Res. 62, 1103-1109
 |  Abstract »  |  Full Text »  |  PDF »

IL-2 and Related Cytokines Can Promote T Cell Survival by Activating AKT.

E. Kelly, A. Won, Y. Refaeli, and L. V. Parijs (2002)
J. Immunol. 168, 597-603
 |  Abstract »  |  Full Text »  |  PDF »

Role for lipid rafts in regulating interleukin-2 receptor signaling.

M. D. Marmor and M. Julius (2001)
Blood 98, 1489-1497
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: The Common {{gamma}}-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex.

H. Asao, C. Okuyama, S. Kumaki, N. Ishii, S. Tsuchiya, D. Foster, and K. Sugamura (2001)
J. Immunol. 167, 1-5
 |  Abstract »  |  Full Text »  |  PDF »

Sulfhydryl-2 domain-containing protein tyrosine phosphatase-1 is not a negative regulator of interleukin-4 signaling in murine mast cells.

E. D. White, R. P. Andrews, and G. K. K. Hershey (2001)
J. Leukoc. Biol. 69, 825-830
 |  Abstract »  |  Full Text »

A p74 common gamma receptor chain isoform facilitates IL-2 and IL-15 responses by the myelomonocytic cell line Tf-1{beta}2.

N. L. Monson, T. J. Fenske, S. Wei, A. J. Okragly, J. L.O. de Jong, M. Haak-Frendscho, J. O’Shea, J. Djeu, and P. M. Sondel (2001)
J. Leukoc. Biol. 69, 419-425
 |  Abstract »  |  Full Text »

Fes Mediates the IL-4 Activation of Insulin Receptor Substrate-2 and Cellular Proliferation.

H. Jiang, K. Foltenyi, M. Kashiwada, L. Donahue, B. Vuong, B. Hehn, and P. Rothman (2001)
J. Immunol. 166, 2627-2634
 |  Abstract »  |  Full Text »  |  PDF »

Control of T Cell Development In Vivo by Subdomains Within the IL-7 Receptor {{alpha}}-Chain Cytoplasmic Tail.

B. O. Porter, P. Scibelli, and T. R. Malek (2001)
J. Immunol. 166, 262-269
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin 15: biology and relevance to human disease.

T. A. Fehniger and M. A. Caligiuri (2001)
Blood 97, 14-32
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A soluble form of the murine common {gamma} chain is present at high concentrations in vivo and suppresses cytokine signaling.

U. Mei{beta}ner, H. Blum, M. Schnare, M. Rollinghoff, and A. Gessner (2001)
Blood 97, 183-191
 |  Abstract »  |  Full Text »  |  PDF »

JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling.

B. Sporri, P. E. Kovanen, A. Sasaki, A. Yoshimura, and W. J. Leonard (2001)
Blood 97, 221-226
 |  Abstract »  |  Full Text »  |  PDF »

Efficient Internalization of IL-2 Depends on the Distal Portion of the Cytoplasmic Tail of the IL-2R Common {gamma}-Chain and a Lymphoid Cell Environment.

A. Yu, F. Olosz, C. Y. Choi, and T. R. Malek (2000)
J. Immunol. 165, 2556-2562
 |  Abstract »  |  Full Text »  |  PDF »

Histone deacetylase inhibitors suppress IL-2-mediated gene expression prior to induction of apoptosis.

Y. Koyama, M. Adachi, M. Sekiya, M. Takekawa, and K. Imai (2000)
Blood 96, 1490-1495
 |  Abstract »  |  Full Text »  |  PDF »

Hierarchy of Protein Tyrosine Kinases in Interleukin-2 (IL-2) Signaling: Activation of Syk Depends on Jak3; However, Neither Syk nor Lck Is Required for IL-2-Mediated STAT Activation.

Y.-J. Zhou, K. S. Magnuson, T. P. Cheng, M. Gadina, D. M. Frucht, J. Galon, F. Candotti, R. L. Geahlen, P. S. Changelian, and J. J. O'Shea (2000)
Mol. Cell. Biol. 20, 4371-4380
 |  Abstract »  |  Full Text »

IL-2 Signaling in Human Monocytes Involves the Phosphorylation and Activation of p59hck 1.

M. C. Bosco, R. E. Curiel, A. H. Zea, M. G. Malabarba, J. R. Ortaldo, and I. Espinoza-Delgado (2000)
J. Immunol. 164, 4575-4585
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-4 Mediates Cell Growth Inhibition through Activation of Stat1.

T. L.-Y. Chang, X. Peng, and X.-Y. Fu (2000)
J. Biol. Chem. 275, 10212-10217
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of c-myc Transcription by Interleukin-2 (IL-2). IDENTIFICATION OF A NOVEL IL-2 RESPONSE ELEMENT INTERACTING WITH STAT-4.

I. Grigorieva, V. G. Grigoriev, M. K. Rowney, and R. G. Hoover (2000)
J. Biol. Chem. 275, 7343-7350
 |  Abstract »  |  Full Text »  |  PDF »

The IL-2 Receptor Promotes Lymphocyte Proliferation and Induction of the c-myc, bcl-2, and bcl-x Genes Through the trans-Activation Domain of Stat5.

J. D. Lord, B. C. McIntosh, P. D. Greenberg, and B. H. Nelson (2000)
J. Immunol. 164, 2533-2541
 |  Abstract »  |  Full Text »  |  PDF »

Complex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions between the Kinase and Pseudokinase Domains.

M. Chen, A. Cheng, F. Candotti, Y.-J. Zhou, A. Hymel, A. Fasth, L. D. Notarangelo, and J. J. O'Shea (2000)
Mol. Cell. Biol. 20, 947-956
 |  Abstract »  |  Full Text »

IL-2 Unresponsiveness in Anergic CD4+ T Cells Is Due to Defective Signaling Through the Common {gamma}-Chain of the IL-2 Receptor.

S. Grundstrom, M. Dohlsten, and A. Sundstedt (2000)
J. Immunol. 164, 1175-1184
 |  Abstract »  |  Full Text »  |  PDF »

FUNCTIONAL INTERLEUKIN 4 RECEPTOR AND INTERLEUKIN 2 RECEPTOR COMMON {gamma}-CHAIN ON HUMAN NON-SMALL CELL LUNG CANCERS: NOVEL TARGETS FOR IMMUNE THERAPY.

R. Essner, Y. Huynh, T. Nguyen, D. L. Morton, and D. S. B. Hoon (2000)
J. Thorac. Cardiovasc. Surg. 119, 10-20
 |  Abstract »  |  Full Text »  |  PDF »

CIS Associates with the Interleukin-2 Receptor beta Chain and Inhibits Interleukin-2-dependent Signaling.

M. J. Aman, T.-S. Migone, A. Sasaki, D. P. Ascherman, M.-h. Zhu, E. Soldaini, K. Imada, A. Miyajima, A. Yoshimura, and W. J. Leonard (1999)
J. Biol. Chem. 274, 30266-30272
 |  Abstract »  |  Full Text »  |  PDF »

Reconstitution of Early Lymphoid Proliferation and Immune Function in Jak3-Deficient Mice by Interleukin-3.

M. P. Brown, T. Nosaka, R. A. Tripp, J. Brooks, J. M.A. van Deursen, M. K. Brenner, P. C. Doherty, and J. N. Ihle (1999)
Blood 94, 1906-1914
 |  Abstract »  |  Full Text »  |  PDF »

Activation of STAT5 by IL-4 relies on Janus kinase function but not on receptor tyrosine phosphorylation, and can contribute to both cell proliferation and gene regulation.

K. Friedrich, W. Kammer, I. Erhardt, S. Brandlein, W. Sebald, and R. Moriggl (1999)
Int. Immunol. 11, 1283-1294
 |  Abstract »  |  Full Text »  |  PDF »

One Lyn molecule is sufficient to initiate phosphorylation of aggregated high-affinity IgE receptors.

C. Wofsy, B. M. Vonakis, H. Metzger, and B. Goldstein (1999)
PNAS 96, 8615-8620
 |  Abstract »  |  Full Text »  |  PDF »

Diacylglycerol Kinase Inhibition Prevents IL-2-Induced G1 to S Transition Through a Phosphatidylinositol-3 Kinase-Independent Mechanism.

I. Flores, D. R. Jones, A. Cipres, E. Diaz-Flores, M. A. Sanjuan, and I. Merida (1999)
J. Immunol. 163, 708-714
 |  Abstract »  |  Full Text »  |  PDF »

Efficient Gene Delivery to Quiescent Interleukin-2 (IL-2)-Dependent Cells by Murine Leukemia Virus-Derived Vectors Harboring IL-2 Chimeric Envelopes Glycoproteins.

M. Maurice, S. Mazur, F. J. Bullough, A. Salvetti, M. K.L. Collins, S. J. Russell, and F.-L. Cosset (1999)
Blood 94, 401-410
 |  Abstract »  |  Full Text »  |  PDF »

Possible Involvement of a Novel STAM-associated Molecule "AMSH" in Intracellular Signal Transduction Mediated by Cytokines.

N. Tanaka, K. Kaneko, H. Asao, H. Kasai, Y. Endo, T. Fujita, T. Takeshita, and K. Sugamura (1999)
J. Biol. Chem. 274, 19129-19135
 |  Abstract »  |  Full Text »  |  PDF »

p70s6k Integrates Phosphatidylinositol 3-Kinase and Rapamycin-Regulated Signals for E2F Regulation in T Lymphocytes.

P. Brennan, J. W. Babbage, G. Thomas, and D. Cantrell (1999)
Mol. Cell. Biol. 19, 4729-4738
 |  Abstract »  |  Full Text »  |  PDF »

The Identification of Phosphatidylinositol 3,5-bisphosphate in T-lymphocytes and Its Regulation by Interleukin-2.

D. R. Jones, A. Gonzalez-Garcia, E. Diez, C. Martinez-A., A. C. Carrera, and I. Merida (1999)
J. Biol. Chem. 274, 18407-18413
 |  Abstract »  |  Full Text »  |  PDF »

Attenuation of Interleukin 2 Signal in the Spleen Cells of Complex Ganglioside-lacking Mice.

J. Zhao, K. Furukawa, S. Fukumoto, M. Okada, R. Furugen, H. Miyazaki, K. Takamiya, S. Aizawa, H. Shiku, T. Matsuyama, et al. (1999)
J. Biol. Chem. 274, 13744-13747
 |  Abstract »  |  Full Text »  |  PDF »

Downregulation of JAK3 Protein Levels in T Lymphocytes by Prostaglandin E2 and Other Cyclic Adenosine Monophosphate-Elevating Agents: Impact on Interleukin-2 Receptor Signaling Pathway.

V. Kolenko, P. Rayman, B. Roy, M. K. Cathcart, J. O'Shea, R. Tubbs, L. Rybicki, R. Bukowski, and J. Finke (1999)
Blood 93, 2308-2318
 |  Abstract »  |  Full Text »  |  PDF »

IL-2-Mediated Cell Cycle Progression and Inhibition of Apoptosis Does Not Require NF-{kappa}B or Activating Protein-1 Activation in Primary Human T Cells.

M. Iacobelli, F. Rohwer, P. Shanahan, J. A. Quiroz, and K. L. McGuire (1999)
J. Immunol. 162, 3308-3315
 |  Abstract »  |  Full Text »  |  PDF »

Interferon-alpha Activates Multiple STAT Proteins and Upregulates Proliferation-Associated IL-2Ralpha , c-myc, and pim-1 Genes in Human T Cells.

S. Matikainen, T. Sareneva, T. Ronni, A. Lehtonen, P. J. Koskinen, and I. Julkunen (1999)
Blood 93, 1980-1991
 |  Abstract »  |  Full Text »  |  PDF »

Role of Interleukin (IL)-2 Receptor beta -Chain Subdomains and Shc in p38 Mitogen-activated Protein (MAP) Kinase and p54 MAP Kinase (Stress-activated Protein Kinase/c-Jun N-terminal Kinase) Activation. IL-2-DRIVEN PROLIFERATION IS INDEPENDENT OF p38 AND p54 MAP KINASE ACTIVATION.

A. E. Hunt, F. V. Lali, J. D. Lord, B. H. Nelson, T. Miyazaki, K. J. Tracey, and B. M. J. Foxwell (1999)
J. Biol. Chem. 274, 7591-7597
 |  Abstract »  |  Full Text »  |  PDF »

The Significance of Tetramerization in Promoter Recruitment by Stat5.

S. John, U. Vinkemeier, E. Soldaini, J. E. Darnell Jr., and W. J. Leonard (1999)
Mol. Cell. Biol. 19, 1910-1918
 |  Abstract »  |  Full Text »  |  PDF »

IL-4 Selectively Inhibits IL-2-Triggered Stat5 Activation, But Not Proliferation, in Human T Cells.

A. Castro, T. K. Sengupta, D. C. Ruiz, E. Yang, and L. B. Ivashkiv (1999)
J. Immunol. 162, 1261-1269
 |  Abstract »  |  Full Text »  |  PDF »

Thymic Stromal Lymphopoietin: A Cytokine That Promotes the Development of IgM+ B Cells In Vitro and Signals Via a Novel Mechanism.

S. D. Levin, R. M. Koelling, S. L. Friend, D. E. Isaksen, S. F. Ziegler, R. M. Perlmutter, and A. G. Farr (1999)
J. Immunol. 162, 677-683
 |  Abstract »  |  Full Text »  |  PDF »

IgE Hyperproduction Through Enhanced Tyrosine Phosphorylation of Janus Kinase 3 in NC/Nga Mice, a Model for Human Atopic Dermatitis.

M. Matsumoto, C. Ra, K. Kawamoto, H. Sato, A. Itakura, J. Sawada, H. Ushio, H. Suto, K. Mitsuishi, Y. Hikasa, et al. (1999)
J. Immunol. 162, 1056-1063
 |  Abstract »  |  Full Text »  |  PDF »

Functional Role of Interleukin-4 (IL-4) and IL-7 in the Development of X-Linked Severe Combined Immunodeficiency.

S. Kumaki, N. Ishii, M. Minegishi, S. Tsuchiya, D. Cosman, K. Sugamura, and T. Konno (1999)
Blood 93, 607-612
 |  Abstract »  |  Full Text »  |  PDF »

Signaling via the IL-2 and IL-7 Receptors from the Membrane to the Nucleus.

W.J. LEONARD, K. IMADA, H. NAKAJIMA, A. PUEL, E. SOLDAINI, and S. JOHN (1999)
Cold Spring Harb Symp Quant Biol 64, 417-424
 |  Abstract »  |  PDF »

Interleukin 7 Receptor Control of  T Cell Receptor gamma  Gene Rearrangement: Role of Receptor-associated Chains and Locus Accessibility.

S. K. Durum, S. Candeias, H. Nakajima, W. J. Leonard, A. M. Baird, L. J. Berg, and K. Muegge (1998)
J. Exp. Med. 188, 2233-2241
 |  Abstract »  |  Full Text »  |  PDF »

The Interleukin-4 Receptor Activates STAT5 by a Mechanism That Relies upon Common gamma -Chain.

A. Lischke, R. Moriggl, S. Brandlein, S. Berchtold, W. Kammer, W. Sebald, B. Groner, X. Liu, L. Hennighausen, and K. Friedrich (1998)
J. Biol. Chem. 273, 31222-31229
 |  Abstract »  |  Full Text »  |  PDF »

MRG1, the product of a melanocyte-specific gene related gene, is a cytokine-inducible transcription factor with transformation activity.

H. B. Sun, Y. X. Zhu, T. Yin, G. Sledge, and Y.-C. Yang (1998)
PNAS 95, 13555-13560
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin 2-mediated Uncoupling of T Cell Receptor alpha /beta from CD3 Signaling.

L. Haughn, B. Leung, L. Boise, A. Veillette, C. Thompson, and M. Julius (1998)
J. Exp. Med. 188, 1575-1586
 |  Abstract »  |  Full Text »  |  PDF »

Functional Cooperation of the Interleukin-2 Receptor beta  Chain and Jak1 in Phosphatidylinositol 3-Kinase Recruitment and Phosphorylation.

T.-S. Migone, S. Rodig, N. A. Cacalano, M. Berg, R. D. Schreiber, and W. J. Leonard (1998)
Mol. Cell. Biol. 18, 6416-6422
 |  Abstract »  |  Full Text »

The IL-2 Receptor Promotes Proliferation, bcl-2 and bcl-x Induction, But Not Cell Viability Through the Adapter Molecule Shc.

J. D. Lord, B. C. McIntosh, P. D. Greenberg, and B. H. Nelson (1998)
J. Immunol. 161, 4627-4633
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Mapping with Functional Antibodies Localizes Critical Sites on the Human IL Receptor Common {gamma} ({gamma}c) Chain.

N. Raskin, A. Jakubowski, I. Sizing, D. L. Olson, S. L. Kalled, C. A. Hession, C. D. Benjamin, D. P. Baker, and L. C. Burkly (1998)
J. Immunol. 161, 3474-3483
 |  Abstract »  |  Full Text »  |  PDF »

Endocytosis of the Common Cytokine Receptor gamma c Chain. IDENTIFICATION OF SEQUENCES INVOLVED IN INTERNALIZATION AND DEGRADATION.

E. Morelon and A. Dautry-Varsat (1998)
J. Biol. Chem. 273, 22044-22051
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of a Mobile Stat6 Activation Motif in the Human IL-4 Receptor.

J. J. Ryan, L. J. McReynolds, H. Huang, K. Nelms, and W. E. Paul (1998)
J. Immunol. 161, 1811-1821
 |  Abstract »  |  Full Text »  |  PDF »

A New Tyrosine-phosphorylated 97-kDa Adaptor Protein Mediates Interleukin-2-induced Association of SHP-2 with p85-Phosphatidylinositol 3-Kinase in Human T Lymphocytes.

F. Gesbert, C. Guenzi, and J. Bertoglio (1998)
J. Biol. Chem. 273, 18273-18281
 |  Abstract »  |  Full Text »  |  PDF »

Differential Regulation of the Janus Kinase-STAT Pathway and Biologic Function of IL-13 in Primary Human NK and T Cells: A Comparative Study with IL-4.

C.-R. Yu, R. A. Kirken, M. G. Malabarba, H. A. Young, and J. R. Ortaldo (1998)
J. Immunol. 161, 218-227
 |  Abstract »  |  Full Text »  |  PDF »

Human and Simian T-Cell Leukemia Viruses Type 2 (HTLV-2 and STLV-2pan-p) Transform T Cells Independently of Jak/STAT Activation.

J. C. Mulloy, T.-S. Migone, T. M. Ross, N. Ton, P. L. Green, W. J. Leonard, and G. Franchini (1998)
J. Virol. 72, 4408-4412
 |  Abstract »  |  Full Text »  |  PDF »

Delineation of the Regions of Interleukin-2 (IL-2) Receptor beta  Chain Important for Association of Jak1 and Jak3. Jak1-INDEPENDENT FUNCTIONAL RECRUITMENT OF Jak3 TO IL-2Rbeta.

M.-h. Zhu, J. A. Berry, S. M. Russell, and W. J. Leonard (1998)
J. Biol. Chem. 273, 10719-10725
 |  Abstract »  |  Full Text »  |  PDF »

A Role for the Insulin-Interleukin (IL)-4 Receptor Motif of the IL-4 Receptor alpha -Chain in Regulating Activation of the Insulin Receptor Substrate 2 and Signal Transducer and Activator of Transcription 6 Pathways. ANALYSIS BY MUTAGENESIS.

H. Y. Wang, J. Zamorano, and A. D. Keegan (1998)
J. Biol. Chem. 273, 9898-9905
 |  Abstract »  |  Full Text »  |  PDF »

Stat Proteins Control Lymphocyte Proliferation by Regulating p27Kip1 Expression.

M. H. Kaplan, C. Daniel, U. Schindler, and M. J. Grusby (1998)
Mol. Cell. Biol. 18, 1996-2003
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Regulation of Cell Growth by IL-2: Role of STAT5 in Protection from Apoptosis But Not in Cell Cycle Progression.

J. Zamorano, H. Y. Wang, R. Wang, Y. Shi, G. D. Longmore, and A. D. Keegan (1998)
J. Immunol. 160, 3502-3512
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Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells.

T.-S. Migone, N. A. Cacalano, N. Taylor, T. Yi, T. A. Waldmann, and J. A. Johnston (1998)
PNAS 95, 3845-3850
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Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway.

T. Miyazaki, A. Takaoka, L. Nogueira, I. Dikic, H. Fujii, S. Tsujino, Y. Mitani, M. Maeda, J. Schlessinger, and T. Taniguchi (1998)
Genes & Dev. 12, 770-775
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Erythropoietin and Friend Virus gp55 Activate Different JAK/STAT Pathways through the Erythropoietin Receptor in Erythroid Cells.

Y. Yamamura, H. Senda, Y. Kageyama, T. Matsuzaki, M. Noda, and Y. Ikawa (1998)
Mol. Cell. Biol. 18, 1172-1180
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Requirement for Jak3 in Mature T Cells: Its Role in Regulation of T Cell Homeostasis.

S. J. Sohn, K. A. Forbush, N. Nguyen, B. Witthuhn, T. Nosaka, J. N. Ihle, and R. M. Perlmutter (1998)
J. Immunol. 160, 2130-2138
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Altered Interleukin-12 Responsiveness in Th1 and Th2 Cells Is Associated With the Differential Activation of STAT5 and STAT1.

J. A. Gollob, E. A. Murphy, S. Mahajan, C. P. Schnipper, J. Ritz, and D. A. Frank (1998)
Blood 91, 1341-1354
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Development of Autologous, Oligoclonal, Poorly Functioning T Lymphocytes in a Patient With Autosomal Recessive Severe Combined Immunodeficiency Caused by Defects of the Jak3 Tyrosine Kinase.

D. Brugnoni, L. D. Notarangelo, A. Sottini, P. Airo, M. Pennacchio, E. Mazzolari, S. Signorini, F. Candotti, A. Villa, P. Mella, et al. (1998)
Blood 91, 949-955
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Nitric oxide and thiol redox regulation of Janus kinase activity.

R. J. Duhe, G. A. Evans, R. A. Erwin, R. A. Kirken, G. W. Cox, and W. L. Farrar (1998)
PNAS 95, 126-131
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Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity.

Y.-J. Zhou, E. P. Hanson, Y.-Q. Chen, K. Magnuson, M. Chen, P. G. Swann, R. L. Wange, P. S. Changelian, and J. J. O'Shea (1997)
PNAS 94, 13850-13855
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Mouse Brain Microglia Express Interleukin-15 and Its Multimeric Receptor Complex Functionally Coupled to Janus Kinase Activity.

U.-K. Hanisch, S. A. Lyons, M. Prinz, C. Nolte, J. R. Weber, H. Kettenmann, and F. Kirchhoff (1997)
J. Biol. Chem. 272, 28853-28860
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