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Science 24 November 1995:
Vol. 270. no. 5240, pp. 1369 - 1372
DOI: 10.1126/science.270.5240.1369
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Reports

Regulated Expression of the Neural Cell Adhesion Molecule L1 by Specific Patterns of Neural Impulses

Kouichi Itoh,  Beth Stevens,  Melitta Schachner,  R. Douglas Fields (1)

Development of the mammalian nervous system is regulated by neural impulse activity, but the molecular mechanisms are not well understood. If cell recognition molecules [for example, L1 and the neural cell adhesion molecule (NCAM)] were influenced by specific patterns of impulse activity, cell-cell interactions controlling nervous system structure could be regulated by nervous system function at critical stages of development. Low-frequency electrical pulses delivered to mouse sensory neurons in culture (0.1 hertz for 5 days) down-regulated expression of L1 messenger RNA and protein (but not NCAM). Fasciculation of neurites, adhesion of neuroblastoma cells, and the number of Schwann cells on neurites was reduced after 0.1-hertz stimulation, but higher frequencies or stimulation after synaptogenesis were without effect.


K. Itoh, B. Stevens, R. D. Fields, National Institutes of Health, National Institute of Child Health and Human Development, LDN 49/5A38, Neurocytology and Physiology Unit, Bethesda, MD 20892, USA.
M. Schachner, Department of Neurobiology, Swiss Federal Institute of Technology, Honggerberg, 8093 Zurich, Switzerland.
(1) To whom correspondence should be addressed.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)