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Science 1 November 1996:
Vol. 274. no. 5288, pp. 792 - 795
DOI: 10.1126/science.274.5288.792
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Reports

Protection from Natural Killer Cell-Mediated Lysis by HLA-G Expression on Target Cells

Laszlo Pazmany, * Ofer Mandelboim, * Mar Valés-Gómez, Daniel M. Davis, Hugh T. Reyburn, Jack L. Strominger

The outermost layer of the human placenta is devoid of classical class I human leukocyte antigens (HLA-A, HLA-B, and HLA-C) and class II proteins (HLA-DR, HLA-DQ, and HLA-DP). Although this prevents recognition by maternal T lymphocytes, the lack of class I molecules leaves these cells susceptible to attack by natural killer (NK) cells. However, trophoblast cells directly in contact with the maternal tissues express the class I molecule HLA-G, which may be involved in protecting the trophoblast from recognition by NK cells. Here evidence is provided that expression of HLA-G is sufficient to protect otherwise susceptible target cells from lysis by activated NK1 and NK2 cell lines and clones that are specific for distinct groups of HLA-C alleles. The receptors on NK cells that recognize HLA-G are also identified.

Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA.
*   These authors contributed equally to this work.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)