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Science 22 November 1996:
Vol. 274. no. 5291, pp. 1363 - 1366
DOI: 10.1126/science.274.5291.1363
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Reports

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

M. Hahne, D. Rimoldi, M. Schröter, P. Romero, M. Schreier, L. E. French, P. Schneider, T. Bornand, A. Fontana, D. Lienard, J.-C. Cerottini, J. Tschopp *

Malignant melanoma accounts for most of the increasing mortality from skin cancer. Melanoma cells were found to express Fas (also called Apo-1 or CD95) ligand (FasL). In metastatic lesions, Fas-expressing T cell infiltrates were proximal to FasL+ tumor cells. In vitro, apoptosis of Fas-sensitive target cells occurred upon incubation with melanoma tumor cells; and in vivo, injection of FasL+ mouse melanoma cells in mice led to rapid tumor formation. In contrast, tumorigenesis was delayed in Fas-deficient lpr mutant mice in which immune effector cells cannot be killed by FasL. Thus, FasL may contribute to the immune privilege of tumors.

M. Hahne, M. Schröter, P. Schneider, T. Bornand, J. Tschopp, Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.
D. Rimoldi, P. Romero, M. Schreier, J.-C. Cerottini, Ludwig Institute of Cancer Research, Lausanne branch, University of Lausanne, CH-1066 Epalinges, Switzerland.
L. E. French, Department of Dermatology, University of Geneva, Medical School, CH-1211 Geneva 4, Switzerland.
A. Fontana, Clinical Immunology, Department of Internal Medicine, University Hospital, CH-8044 Zürich, Switzerland.
D. Lienard, Centre Pluridisciplinaire d'Oncologie, CHUV, CH-1011 Lausanne, Switzerland.
*   To whom correspondence should be addressed. E-mail: jurg.tschopp{at}ib.unil.ch

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T. Waku, T. Fujiwara, J. Shao, T. Itoshima, T. Murakami, M. Kataoka, S. Gomi, J. A. Roth, and N. Tanaka (2000)
J. Immunol. 165, 5884-5890
   Abstract »    Full Text »    PDF »
Inhibition of Daxx-Mediated Apoptosis by Heat Shock Protein 27.
S. J. Charette, J. N. Lavoie, H. Lambert, and J. Landry (2000)
Mol. Cell. Biol. 20, 7602-7612
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CM101 Treatment Overrides Tumor-induced Immunoprivilege Leading to Apoptosis.
F. M. Yakes, B. D. Wamil, F. Sun, H.-P. Yan, C. E. Carter, and C. G. Hellerqvist (2000)
Cancer Res. 60, 5740-5746
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The Mechanism of Unresponsiveness to Circulating Tumor Antigen MUC1 Is a Block in Intracellular Sorting and Processing by Dendritic Cells.
E. M. Hiltbold, A. M. Vlad, P. Ciborowski, S. C. Watkins, and O. J. Finn (2000)
J. Immunol. 165, 3730-3741
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Frequency of Apoptosis of Tumor-infiltrating Lymphocytes Induced by Fas Counterattack in Human Colorectal Carcinoma and Its Correlation with Prognosis.