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Science 3 October 1997:
Vol. 278. no. 5335, pp. 141 - 144
DOI: 10.1126/science.278.5335.141
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Reports

Evidence for a Role of CRM1 in Signal-Mediated Nuclear Protein Export

Batool Ossareh-Nazari, Françoise Bachelerie, Catherine Dargemont *

Chromosome maintenance region 1 (CRM1), a protein that shares sequence similarities with the karyopherin beta  family of proteins involved in nuclear import pathway, was shown to form a complex with the leucine-rich nuclear export signal (NES). This interaction was inhibited by leptomycin B, a drug that prevents the function of the CRM1 protein in yeast. To analyze the role of the CRM1-NES interaction in nuclear export, a transport assay based on semipermeabilized cells was developed. In this system, which reconstituted NES-, cytosol-, and energy-dependent nuclear export, leptomycin B specifically blocked export of NES-containing proteins. Thus, the CRM1 protein could act as a NES receptor involved in nuclear protein export.

B. Ossareh-Nazari and C. Dargemont, Institut Curie- CNRS Unité Mixte de Recherche 144, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
F. Bachelerie, Institut Pasteur, Unite d'Immunologie Virale, 75015 Paris, France.
*   To whom correspondence should be addressed. E-mail: dargemon{at}curie.fr

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Direct Participation of Sam68, the 68-Kilodalton Src-Associated Protein in Mitosis, in the CRM1-Mediated Rev Nuclear Export Pathway.
J. Li, Y. Liu, B. O. Kim, and J. J. He (2002)
J. Virol. 76, 8374-8382
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