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Science 10 October 1997:
Vol. 278. no. 5336, pp. 298 - 301
DOI: 10.1126/science.278.5336.298
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Reports

V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses

Fotini Papavasiliou, Rafael Casellas, Heikyung Suh, Xiao-Feng Qin, Eva Besmer, Roberta Pelanda, David Nemazee, Klaus Rajewsky, Michel C. Nussenzweig *

The clonal selection theory states that B lymphocytes producing high-affinity immunoglobulins are selected from a pool of cells undergoing antibody gene mutation. Somatic hypermutation is a well-documented mechanism for achieving diversification of immune responses in mature B cells. Antibody genes were also found to be modified in such cells in germinal centers by recombination of the variable (V), diversity (D), and joining (J) segments. The ability to alter immunoglobulin expression by V(D)J recombination in the selective environment of the germinal center may be an additional mechanism for inactivation or diversification of immune responses.

F. Papavasiliou, R. Casellas, X.-F. Qin, Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10021, USA.
H. Suh, E. Besmer, M. C. Nussenzweig, Laboratory of Molecular Immunology and Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021, USA.
R. Pelanda, Max Plank Institute for Immunobiology, Freiburg, Germany 79108.
D. Nemazee, Division of Basic Sciences, Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA.
K. Rajewsky, Institute for Genetics, University of Cologne, Weyertal, Germany 50931.
*   To whom correspondence should be addressed. E-mail: nussen{at}rockvax.rockefeller.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)