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Science 28 November 1997:
Vol. 278. no. 5343, pp. 1638 - 1641
DOI: 10.1126/science.278.5343.1638
Prev | Table of Contents | Next

Reports

Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway

Chi-Wing Chow, Mercedes Rincón, Julie Cavanagh, Martin Dickens, Roger J. Davis *

The nuclear factor of activated T cells (NFAT) group of transcription factors is retained in the cytoplasm of quiescent cells. NFAT activation is mediated in part by induced nuclear import. This process requires calcium-dependent dephosphorylation of NFAT caused by the phosphatase calcineurin. The c-Jun amino-terminal kinase (JNK) phosphorylates NFAT4 on two sites. Mutational removal of the JNK phosphorylation sites caused constitutive nuclear localization of NFAT4. In contrast, JNK activation in calcineurin-stimulated cells caused nuclear exclusion of NFAT4. These findings show that the nuclear accumulation of NFAT4 promoted by calcineurin is opposed by the JNK signal transduction pathway.

C.-W. Chow, J. Cavanagh, M. Dickens, R. J. Davis, Howard Hughes Medical Institute, Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
M. Rincón, Program in Immunobiology, Department of Medicine, University of Vermont, Burlington, VT 05405, USA.
*   To whom correspondence should be addressed.

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Activation and Cellular Localization of the Cyclosporine A-sensitive Transcription Factor NF-AT in Skeletal Muscle Cells.
K. L. Abbott, B. B. Friday, D. Thaloor, T.J. Murphy, and G. K. Pavlath (1998)
Mol. Biol. Cell 9, 2905-2916
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Rac-1 Regulates Nuclear Factor of Activated T Cells (NFAT) C1 Nuclear Translocation in Response to Fcepsilon Receptor Type 1 Stimulation of Mast Cells.
H. Turner, M. Gomez, E. McKenzie, A. Kirchem, A. Lennard, and D. A. Cantrell (1998)
J. Exp. Med. 188, 527-537
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Heat Stress Activates Fission Yeast Spc1/StyI MAPK by a MEKK-Independent Mechanism.
K. Shiozaki, M. Shiozaki, and P. Russell (1998)
Mol. Biol. Cell 9, 1339-1349
   Abstract »    Full Text »
The Tpl-2 protooncoprotein activates the nuclear factor of activated T cells and induces interleukin 2 expression in T cell lines.