Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Johnson & Johnson

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 12 December 1997:
Vol. 278. no. 5345, pp. 1937 - 1940
DOI: 10.1126/science.278.5345.1937
Prev | Table of Contents | Next

Reports

Cleavage of the BMP-4 Antagonist Chordin by Zebrafish Tolloid

Patrick Blader, * Sepand Rastegar, * Nadine Fischer, Uwe Strähle dagger

Dorsoventral patterning of vertebrate and Drosophila embryos requires bone morphogenetic proteins (BMPs) and antagonists of BMP activity. The Drosophila gene tolloid encodes a metalloprotease similar to BMP-1 that interacts genetically with decapentaplegic, the Drosophila homolog of vertebrate BMP-2/4. Zebrafish embryos overexpressing a zebrafish homolog of tolloid were shown to resemble loss-of-function mutations in chordino, the zebrafish homolog of the Xenopus BMP-4 antagonist Chordin. Furthermore, Chordin was degraded by COS cells expressing Tolloid. These data suggest that Tolloid antagonizes Chordin activity by proteolytically cleaving Chordin. A conserved function for zebrafish and Drosophila Tolloid during embryogenesis is proposed.

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, BP 163, 67404 Illkirch Cedex, C.U. de Strasbourg, France.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: uwe{at}titus.u-strasbg.fr

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Presynaptic Contributions of Chordin to Hippocampal Plasticity and Spatial Learning.
M. Sun, M. J. Thomas, R. Herder, M. L. Bofenkamp, S. B. Selleck, and M. B. O'Connor (2007)
J. Neurosci. 27, 7740-7750
   Abstract »    Full Text »    PDF »
Bone Morphogenetic Protein 1 Prodomain Specifically Binds and Regulates Signaling by Bone Morphogenetic Proteins 2 and 4.
R. Jasuja, G. Ge, N. G. Voss, J. Lyman-Gingerich, A. M. Branam, F. J. Pelegri, and D. S. Greenspan (2007)
J. Biol. Chem. 282, 9053-9062
   Abstract »    Full Text »    PDF »
The metalloprotease Tolloid-related and its TGF-{beta}-like substrate Dawdle regulate Drosophila motoneuron axon guidance..
M. Serpe and M. B. O'Connor (2006)
Development 133, 4969-4979
   Abstract »    Full Text »    PDF »
BMP1 controls TGF{beta}1 activation via cleavage of latent TGF{beta}-binding protein.
G. Ge and D. S. Greenspan (2006)
J. Cell Biol. 175, 111-120
   Abstract »    Full Text »    PDF »
A {beta}1,4-galactosyltransferase is required for Bmp2-dependent patterning of the dorsoventral axis during zebrafish embryogenesis.
Q. J. Machingo, A. Fritz, and B. D. Shur (2006)
Development 133, 2233-2241
   Abstract »    Full Text »    PDF »
A Complete Domain Structure of Drosophila Tolloid Is Required for Cleavage of Short Gastrulation.
E. G. Canty, L. Garrigue-Antar, and K. E. Kadler (2006)
J. Biol. Chem. 281, 13258-13267
   Abstract »    Full Text »    PDF »
Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation.
F. Rentzsch, J. Zhang, C. Kramer, W. Sebald, and M. Hammerschmidt (2006)
Development 133, 801-811
   Abstract »    Full Text »    PDF »
Use of Differentiating Adult Stem Cells (Marrow Stromal Cells) to Identify New Downstream Target Genes for Transcription Factors.
J. Ylostalo, J. R. Smith, R. R. Pochampally, R. Matz, I. Sekiya, B. L. Larson, J. T. Vuoristo, and D. J. Prockop (2006)
Stem Cells 24, 642-652
   Abstract »    Full Text »    PDF »
Matching catalytic activity to developmental function: Tolloid-related processes Sog in order to help specify the posterior crossvein in the Drosophila wing.
M. Serpe, A. Ralston, S. S. Blair, and M. B. O'Connor (2005)
Development 132, 2645-2656
   Abstract »    Full Text »    PDF »
Twisted gastrulation enhances BMP signaling through chordin dependent and independent mechanisms.
J. Xie and S. Fisher (2005)
Development 132, 383-391
   Abstract »    Full Text »    PDF »
Cell-surface Heparan Sulfate Proteoglycans Potentiate Chordin Antagonism of Bone Morphogenetic Protein Signaling and Are Necessary for Cellular Uptake of Chordin.
R. Jasuja, B. L. Allen, W. N. Pappano, A. C. Rapraeger, and D. S. Greenspan (2004)
J. Biol. Chem. 279, 51289-51297
   Abstract »    Full Text »    PDF »
Purification and Cloning of an Endogenous Protein Inhibitor of Carp Nephrosin, an Astacin Metalloproteinase.
P.-L. Tsai, C.-H. Chen, C.-J. Huang, C.-M. Chou, and G.-D. Chang (2004)
J. Biol. Chem. 279, 11146-11155
   Abstract »    Full Text »    PDF »
Bone Morphogenetic Protein-1/Tolloid-like Proteinases Process Dentin Matrix Protein-1.
B. M. Steiglitz, M. Ayala, K. Narayanan, A. George, and D. S. Greenspan (2004)
J. Biol. Chem. 279, 980-986
   Abstract »    Full Text »    PDF »
Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases.
N. M. Wolfman, A. C. McPherron, W. N. Pappano, M. V. Davies, K. Song, K. N. Tomkinson, J. F. Wright, L. Zhao, S. M. Sebald, D. S. Greenspan, et al. (2003)
PNAS 100, 15842-15846
   Abstract »    Full Text »    PDF »
Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of the Drosophila embryo.
O. Shimmi and M. B. O'Connor (2003)
Development 130, 4673-4682
   Abstract »    Full Text »    PDF »
Use of Bmp1/Tll1 Doubly Homozygous Null Mice and Proteomics To Identify and Validate In Vivo Substrates of Bone Morphogenetic Protein 1/Tolloid-Like Metalloproteinases.
W. N. Pappano, B. M. Steiglitz, I. C. Scott, D. R. Keene, and D. S. Greenspan (2003)
Mol. Cell. Biol. 23, 4428-4438
   Abstract »    Full Text »    PDF »
Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling.
T. Yabe, T. Shimizu, O. Muraoka, Y.-K. Bae, T. Hirata, H. Nojima, A. Kawakami, T. Hirano, and M. Hibi (2003)
Development 130, 2705-2716
   Abstract »    Full Text »    PDF »
Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton.
E. Canalis, A. N. Economides, and E. Gazzerro (2003)
Endocr. Rev. 24, 218-235
   Abstract »    Full Text »    PDF »
Gelsolin is a dorsalizing factor in zebrafish.
J. Kanungo, Z. Kozmik, S. K. Swamynathan, and J. Piatigorsky (2003)
PNAS 100, 3287-3292
   Abstract »    Full Text »    PDF »
Inhibin Is an Antagonist of Bone Morphogenetic Protein Signaling.
E. Wiater and W. Vale (2003)
J. Biol. Chem. 278, 7934-7941
   Abstract »    Full Text »    PDF »
Non-cell autonomous requirement for the bloodless gene in primitive hematopoiesis of zebrafish.
E. C. Liao, N. S. Trede, D. Ransom, A. Zapata, M. Kieran, and L. I. Zon (2002)
Development 129, 649-659
   Abstract »    Full Text »    PDF »
Proteolytic cleavage of Chordin as a switch for the dual activities of Twisted gastrulation in BMP signaling.
J. Larrain, M. Oelgeschlager, N. I. Ketpura, B. Reversade, L. Zakin, and E. M. De Robertis (2001)
Development 128, 4439-4447
   Abstract »    Full Text »    PDF »
The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo.
H Bauer, Z Lele, G. Rauch, R Geisler, and M Hammerschmidt (2001)
Development 128, 849-858
   Abstract »    PDF »
Bone Morphogenetic Protein (BMP) Localization in Developing Human and Rat Growth Plate, Metaphysis, Epiphysis, and Articular Cartilage.
H. C. Anderson, P. T. Hodges, X. M. Aguilera, L. Missana, and P. E. Moylan (2000)
J. Histochem. Cytochem. 48, 1493-1502
   Abstract »    Full Text »
Zebrafish developmental genetics and central nervous system development.
P. Blader and U. Strahle (2000)
Hum. Mol. Genet. 9, 945-951
   Abstract »    Full Text »    PDF »
Controlling TGF-beta signaling.
J. Massagué and Y.-G. Chen (2000)
Genes & Dev. 14, 627-644
   Full Text »
Identification and characterization of hydra metalloproteinase 2 (HMP2): a meprin-like astacin metalloproteinase that functions in foot morphogenesis.
L Yan, K Fei, J Zhang, S Dexter, and M. Sarras (2000)
Development 127, 129-141
   Abstract »    PDF »
Essential role of Bmp7 (snailhouse) and its prodomain in dorsoventral patterning of the zebrafish embryo.
A Dick, M Hild, H Bauer, Y Imai, H Maifeld, A. Schier, W. Talbot, T Bouwmeester, and M Hammerschmidt (2000)
Development 127, 343-354
   Abstract »    PDF »
Specificity, diversity, and regulation in TGF-{beta} superfamily signaling.
E. PIEK, C.-H. HELDIN, and P. TEN DIJKE (1999)
FASEB J 13, 2105-2124
   Abstract »    Full Text »
The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart.
T. Clark, S. Conway, I. Scott, P. Labosky, G Winnier, J Bundy, B. Hogan, and D. Greenspan (1999)
Development 126, 2631-2642
   Abstract »    PDF »
The role of tolloid/mini fin in dorsoventral pattern formation of the zebrafish embryo.
S. Connors, J Trout, M Ekker, and M. Mullins (1999)
Development 126, 3119-3130
   Abstract »    PDF »
Bone Morphogenetic Protein-1 Processes the NH2-terminal Propeptide, and a Furin-like Proprotein Convertase Processes the COOH-terminal Propeptide of pro-alpha 1(V) Collagen.
Y. Imamura, B. M. Steiglitz, and D. S. Greenspan (1998)
J. Biol. Chem. 273, 27511-27517
   Abstract »    Full Text »    PDF »
Bone Morphogenetic Protein 1 Is an Extracellular Processing Enzyme of the Laminin 5 gamma 2 Chain.
S. Amano, I. C. Scott, K. Takahara, M. Koch, M.-F. Champliaud, D. R. Gerecke, D. R. Keene, D. L. Hudson, T. Nishiyama, S. Lee, et al. (2000)
J. Biol. Chem. 275, 22728-22735
   Abstract »    Full Text »    PDF »
Bone Morphogenetic Protein-1 Processes Probiglycan.
I. C. Scott, Y. Imamura, W. N. Pappano, J. M. Troedel, A. D. Recklies, P. J. Roughley, and D. S. Greenspan (2000)
J. Biol. Chem. 275, 30504-30511
   Abstract »    Full Text »    PDF »
Bone Morphogenetic Protein-1 (BMP-1) Mediates C-terminal Processing of Procollagen V Homotrimer.
E. Kessler, A. Fichard, H. Chanut-Delalande, M. Brusel, and F. Ruggiero (2001)
J. Biol. Chem. 276, 27051-27057
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)