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Science 10 December 1999:
Vol. 286. no. 5447, pp. 2159 - 2162
DOI: 10.1126/science.286.5447.2159
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Reports

The Role of CCR7 in TH1 and TH2 Cell Localization and Delivery of B Cell Help in Vivo

David A. Randolph, 12 Guangming Huang, 3 Cynthia J. L. Carruthers, 3 Lindsay E. Bromley, 3 David D. Chaplin 123*

Subsets of murine CD4+ T cells localize to different areas of the spleen after adoptive transfer. Naïve and T helper 1 (TH1) cells, which express the chemokine receptor CCR7, are home to the periarteriolar lymphoid sheath, whereas activated TH2 cells, which lack CCR7, form rings at the periphery of the T cell zones near B cell follicles. Retroviral transduction of TH2 cells with CCR7 forces them to localize in a TH1-like pattern and inhibits their participation in B cell help in vivo but not in vitro. Thus, differential expression of chemokine receptors results in unique cellular migration patterns that are important for effective immune responses.

1 Division of Allergy and Immunology, Department of Internal Medicine;
2 Center for Immunology, Washington University School of Medicine;
3 Howard Hughes Medical Institute, St. Louis, MO 63110, USA.
*   To whom correspondence should be addressed at Howard Hughes Medical Institute, Washington University School of Medicine, 660 South Euclid Avenue, Box 8022, St. Louis, MO 63110, USA. E-mail: chaplin{at}im.wustl.edu

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