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Originally published in Science Express on 15 February 2007
Science 2 March 2007:
Vol. 315. no. 5816, pp. 1243 - 1249
DOI: 10.1126/science.1136281
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Research Articles

Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension

Maurice A. Curtis,1,2 Monica Kam,1 Ulf Nannmark,3 Michelle F. Anderson,2 Mathilda Zetterstrom Axell,2 Carsten Wikkelso,2 Stig Holtås,4 Willeke M. C. van Roon-Mom,1 Thomas Björk-Eriksson,5 Claes Nordborg,6 Jonas Frisén,7 Michael Dragunow,8 Richard L. M. Faull,1* Peter S. Eriksson2*

The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2'-deoxyuridine and become mature neurons in the OB.

1 Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.
2 Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Medicinaregatan 11, Box 432, SE 405 30 Göteborg, Sweden.
3 Institute of Biomedicine at Sahlgrenska Academy, Medicinaregatan 11, Box 432, SE 405 30 Göteborg, Sweden.
4 Department of Radiology, Bruna Stråket 11 plan 2, Sahlgrenska University Hospital, SE 413 45 Göteborg, Sweden.
5 Department of Oncology, Sahlgrenska University Hospital, 413 45 Göteborg, Sweden.
6 Department of Pathology, Sahlgrenska University Hospital, 413 45 Göteborg, Sweden.
7 Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE-171 77 Stockholm, Sweden.
8 Department of Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.

* To whom correspondence should be addressed. E-mail: per{at}neuro.gu.se (P.S.E.); rlm.faull{at}auckland.ac.nz (R.L.M.F.)

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