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Emerging Challenges in Regulatory T Cell Function and Biology
Shimon Sakaguchi1 and
Fiona Powrie2
Much progress has been made in understanding how the immunesystem is regulated, with a great deal of recent interest innaturally occurring CD4+ regulatory T cells that actively engagein the maintenance of immunological self-tolerance and immunehomeostasis. The challenge ahead for immunologists is the furtherelucidation of the molecular and cellular processes that governthe development and function of these cells. From this, excitingpossibilities are emerging for the manipulation of regulatoryT cell pathways in treating immunological diseases and suppressingor augmenting physiological immune responses.
1 Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan. 2 Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
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