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Retraction of Davis et al., Science 291 (5501) 134-137.

Science 20 December 2002:
Vol. 298. no. 5602, p. 2327
DOI: 10.1126/science.298.5602.2327b
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Letters

Retraction

The Report "Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors" (1) harbors a fundamental inaccuracy. Although the chemical structure of compound 4 is correct as presented, we have not been able to reproduce the biological activity of this compound in the neonatal rat model of chemotherapy-induced alopecia. Thus, we must retract our results. We are continuing to investigate several compounds from another structural class of CDK inhibitors that block chemotherapy-induced alopecia in this model.

Stephen T. Davis,
Trans Tech Pharmaceuticals,
4170 Mendenhall Oaks Parkway,
High Point, NC 27265,
USA.

Bill G. Benson,
Department of Discovery Genetics,
Glaxo Wellcome Research and Development,
5 Moore Drive,
Research Triangle Park, NC 27709,
USA.

H. Neal Bramson,
Department of Molecular Biochemistry,
Glaxo Wellcome Research and Development,
5 Moore Drive,
Research Triangle Park, NC 27709,
USA.

Dennis E. Chapman,
Ligand Pharmaceuticals,
10275 Science Center Drive,
San Diego, CA 92121,
USA.

Scott H. Dickerson,
Department of Medicinal Chemistry,
Glaxo Wellcome Research and Development,
5 Moore Drive,
Research Triangle Park, NC 27709,
USA.

Karen M. Dold,
Department of Cancer Biology,
Glaxo Wellcome Research and Development,
5 Moore Drive,
Research Triangle Park, NC 27709,
USA.

Derek J. Eberwein,
Department of Cancer Biology,
Glaxo Wellcome Research and Development,
5 Moore Drive,
Research Triangle Park, NC 27709,
USA.

Mark Edelstein,
Department of Cancer Biology,
Glaxo Wellcome Research and Development,
5 Moore Drive,
Research Triangle Park, NC 27709,
USA.

Stephen V. Frye,
Department of Medicinal Chemistry,
Glaxo Wellcome Research and Development,
5 Moore Drive,
Research Triangle Park, NC 27709,
USA.

Robert T. Gampe Jr.,
Department of Structural Chemistry,
Glaxo Wellcome Research and Development,
5 Moore Drive,
Research Triangle Park,
NC 27709,
USA.

Robert J. Griffin,
Department of Biomet Research Support,
Glaxo Wellcome Research and Development,
5 Moore Drive,
Research Triangle Park,
NC 27709,
USA.

Philip A. Harris,
Department of Medicinal Chemistry,
Glaxo Wellcome Research and Development,
5 Moore Drive,
Research Triangle Park, NC 27709,
USA.

Anne M. Hassell,
Department of Structural Chemistry,
Glaxo Wellcome Research and Development,
5 Moore Drive,
Research Triangle Park, NC 27709,
USA.

William D. Holmes,
Lilly Research Laboratories,
Lilly Corporate Center,
Indiannapolis, IN 46285,
USA.

Robert N. Hunter,
Department of Medicinal Chemistry,
Glaxo Wellcome Research and Development,
5 Moore Drive,
Research Triangle Park, NC 27709,
USA.

Victoria B. Knick,
Department of Cancer Biology,
Glaxo Wellcome Research and Development,
5 Moore Drive,
Research Triangle Park, NC 27709,
USA.

Karen Lackey,
Department of Medicinal Chemistry,
Glaxo Wellcome Research and Development,
5 Moore Drive,
Research Triangle Park, NC 27709,
USA.

Brett Lovejoy,
Pennie & Edmonds LLP,
3300 Hillview Avenue,
Palo Alto, CA 94304,
USA.

Michael J. Luzzio,
Pfizer Inc.,
Pfizer Central Research,
Eastern Point Road,
Groton, CT 06340,
USA.

Doris Murray,
Department of Cancer Biology,
Glaxo Wellcome Research and Development,
5 Moore Drive,
Research Triangle Park, NC 27709,
USA.

Patricia Parker,
2103 St. Mary's Road,
Hillsborough, NC 27278,
USA.

Warren J. Rocque,
Department of Molecular Sciences,
Glaxo Wellcome Research and Development,
5 Moore Drive,
Research Triangle Park, NC 27709,
USA.

Lisa Shewchuk-Chapman,
Department of Structural Chemistry,
Glaxo Wellcome Research and Development,
5 Moore Drive,
Research Triangle Park, NC 27709,
USA.

James M. Veal,
Department of Structural Chemistry,
Glaxo Wellcome Research and Development,
5 Moore Drive,
Research Triangle Park, NC 27709,
USA.

Duncan H. Walker,
Sunesis Pharmaceuticals,
340 Oyster Point Road,
South San Francisco, CA 94080,
USA.

Lee F. Kuyper
Department of Structural Chemistry,
Glaxo Wellcome Research and Development,
5 Moore Drive,
Research Triangle Park, NC 27709,
USA.

Reference

  1. S. T. Davis et al., Science 291, 134 (2001).




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Science. ISSN 0036-8075 (print), 1095-9203 (online)