Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 9 August 1991:
Vol. 253. no. 5020, pp. 669 - 673
DOI: 10.1126/science.1871601
Prev | Table of Contents | Next

Articles

Science, Vol 253, Issue 5020, 669-673
Copyright © 1991 by American Association for the Advancement of Science

articles

Genes for epilepsy mapped in the mouse

ML Rise, WN Frankel, JM Coffin, and TN Seyfried

Department of Biology, Boston College, Chestnut Hill 02167.

The neurological mutant mouse strain E1 is a model for complex partial seizures in humans. The inheritance of epileptic seizures with seven conventional chromosomal markers and over 60 endogenous proviral markers was studied by means of back-crosses of E1 with two seizure-resistant strains, DBA/2J and ABP/LeJ. The major gene responsible for this epileptic phenotype (El-1) was localized to a region distal with respect to the centromere on chromosome 9. At least one other gene, El-2, linked to proviral markers on chromosome 2, also influences the seizure phenotype. In addition, a potential modifier of seizures was detected in the DBA/2J background. The location of El-1 on distal chromosome 9 may allow identification of an epilepsy candidate gene in humans on the basis of conserved synteny with human chromosome 3.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Familial mesial temporal lobe epilepsy maps to chromosome 4q13.2-q21.3.
P. Hedera, M. A. Blair, E. Andermann, F. Andermann, D. D'Agostino, K. A. Taylor, L. Chahine, M. Pandolfo, Y. Bradford, J. L. Haines, et al. (2007)
Neurology 68, 2107-2112
   Abstract »    Full Text »    PDF »
Genetic Dissection of Complex Traits.
E. S. Lander and N. J. Schork (2006)
Focus 4, 442
   Abstract »    Full Text »    PDF »
Combined application of behavior genetics and microarray analysis to identify regional expression themes and gene-behavior associations..
N. E. Letwin, N. Kafkafi, Y. Benjamini, C. Mayo, B. C. Frank, T. Luu, N. H. Lee, and G. I. Elmer (2006)
J. Neurosci. 26, 5277-5287
   Abstract »    Full Text »    PDF »
Development of a New Genetic Model for Absence Epilepsy: Spike-Wave Seizures in C3H/He and Backcross Mice.
W. N. Frankel, B. Beyer, C. R. Maxwell, S. Pretel, V. A. Letts, and S. J. Siegel (2005)
J. Neurosci. 25, 3452-3458
   Abstract »    Full Text »    PDF »
Genetic Mapping of the Absence of Third Molars in EL Mice to Chromosome 3.
R. Nomura, T. Shimizu, Y. Asada, S. Hirukawa, and T. Maeda (2003)
Journal of Dental Research 82, 786-790
   Abstract »    Full Text »    PDF »
Cocaine-Induced Seizure Thresholds: Quantitative Trait Loci Detection and Mapping in Two Populations Derived from the C57BL/6 and DBA/2 Mouse Strains.
H. S. Hain, J. C. Crabbe, S. E. Bergeson, and J. K. Belknap (2000)
J. Pharmacol. Exp. Ther. 293, 180-187
   Abstract »    Full Text »
A Major Effect QTL Determined by Multiple Genes in Epileptic EL Mice.
M. E. Legare, F. S. Bartlett II, and W. N. Frankel (2000)
Genome Res. 10, 42-48
   Abstract »    Full Text »
Mapping Quantitative Trait Loci for Seizure Response to a GABAA Receptor Inverse Agonist in Mice.
H. K. Gershenfeld, P. E. Neumann, X. Li, P. L. St. Jean, and S. M. Paul (1999)
J. Neurosci. 19, 3731-3738
   Abstract »    Full Text »    PDF »
Provisional Mapping of Quantitative Trait Loci for Chronic Ethanol Withdrawal Severity in BXD Recombinant Inbred Mice.
J. C. Crabbe (1998)
J. Pharmacol. Exp. Ther. 286, 263-271
   Abstract »    Full Text »
Sensitivity to the Seizure-Inducing Effects of Nicotine is Associated with Strain-Specific Variants of the alpha 5 and alpha 7 Nicotinic Receptor Subunit Genes.
J. A. Stitzel, J. M. Blanchette, and A. C. Collins (1998)
J. Pharmacol. Exp. Ther. 284, 1104-1111
   Abstract »    Full Text »
The Physiology of Body Weight Regulation: Relevance to the Etiology of Obesity in Children.
M. Rosenbaum and R. L. Leibel (1998)
Pediatrics 101, 525-539
   Abstract »    Full Text »    PDF »
Quantitative Trait Loci Involved in Genetic Predisposition to Acute Alcohol Withdrawal in Mice.
K. J. Buck, P. Metten, J. K. Belknap, and J. C. Crabbe (1997)
J. Neurosci. 17, 3946-3955
   Abstract »    Full Text »    PDF »
Mice devoid of gamma -aminobutyrate type A receptor beta 3 subunit have epilepsy, cleft palate, and hypersensitive behavior.
G. E. Homanics, T. M. DeLorey, L. L. Firestone, J. J. Quinlan, A. Handforth, N. L. Harrison, M. D. Krasowski, C. E. M. Rick, E. R. Korpi, R. Makela, et al. (1997)
PNAS 94, 4143-4148
   Abstract »    Full Text »    PDF »
Convergent Domestication of Cereal Crops by Independent Mutations at Corresponding Genetic Loci.
A. H. Paterson, Y.-R. Lin, Z. Li, K. F. Schertz, J. F. Doebley, S. R. M. Pinson, S.-C. Liu, J. W. Stansel, and J. E. Irvine (1995)
Science 269, 1714-1718
   Abstract »    PDF »
Quantitative trait loci that modify the severity of spotting in piebald mice..
W J Pavan, S Mac, M Cheng, and S M Tilghman (1995)
Genome Res. 5, 29-41
   Abstract »    PDF »
Identification of a Sequence-specific Single-stranded DNA Binding Protein That Suppresses Transcription of the Mouse Myelin Basic Protein Gene.
S. Haas, A. Steplewski, L. D. Siracusa, S. Amini, and K. Khalili (1995)
J. Biol. Chem. 270, 12503-12510
   Abstract »    Full Text »    PDF »
Genetic dissection of complex traits.
E. Lander and N. Schork (1994)
Science 265, 2037-2048
   Abstract »    PDF »
Genetic animal models of alcohol and drug abuse.
J. Crabbe, J. Belknap, and K. Buck (1994)
Science 264, 1715-1723
   Abstract »    PDF »
Forward and reverse genetic approaches to behavior in the mouse.
J. Takahashi, L. Pinto, and M. Vitaterna (1994)
Science 264, 1724-1733
   Abstract »    PDF »
A genetic linkage map of the mouse: current applications and future prospects.
N. Copeland, N. Jenkins, D. Gilbert, J. Eppig, L. Maltais, J. Miller, W. Dietrich, A Weaver, S. Lincoln, R. Steen, et al. (1993)
Science 262, 57-66
   Abstract »    PDF »
Linkage on chromosome 3 of autoimmune diabetes and defective Fc receptor for IgG in NOD mice.
J. Prins, J. Todd, N. Rodrigues, S Ghosh, P. Hogarth, L. Wicker, E Gaffney, P. Podolin, P. Fischer, A Sirotina, et al. (1993)
Science 260, 695-698
   Abstract »    PDF »
Of fin and fur: mutational analysis of vertebrate embryonic development..
J Rossant and N Hopkins (1992)
Genes & Dev. 6, 1-13
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)