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Science 1 December 2000:
Vol. 290. no. 5497, pp. 1709 - 1711
DOI: 10.1126/science.290.5497.1709
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Perspectives

BIOCHEMISTRY:
An Absorbing Study of Cholesterol

Hooman Allayee, Bryan A. Laffitte, Aldons J. Lusis

We obtain sterols from the animal and plant food that we eat. How these plant and animal sterols are absorbed, transported around the body, and excreted has been the subject of much investigation. In a Perspective, Allayee and colleagues discuss a new study (Berge et al.) that implicates two new ABC transporter proteins in the efflux of plant and animal sterols from gut epithelial cells into the gut lumen.

H. Allayee and A. J. Lusis are in the Department of Medicine and the Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles (UCLA) School of Medicine, Los Angeles, CA 90095, USA. B. A. Laffitte is at the Howard Hughes Medical Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA. E-mail: hallayee{at}ucla.edu; jlusis{at}mednet.ucla.edu

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