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Comment on "The Consensus Coding Sequences of Human Breast and Colorectal Cancers"
Alan F. Rubin1 and
Phil Green1,2*
Sjöblom et al. (Research Article, 13 October 2006, p. 268)reported many new genes with an apparent significant excessof mutations in breast and colorectal cancer. Reanalysis oftheir data with more appropriate statistical methods and backgroundmutation rate assumptions reveals that few if any of these geneshave significantly elevated mutation rates.
1 Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. 2 Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
* To whom correspondence should be addressed. E-mail: phg{at}u.washington.edu
Gad Getz, Holger Höfling, Jill P. Mesirov, Todd R. Golub, Matthew Meyerson, Robert Tibshirani, and Eric S. Lander (14 September 2007) Science317 (5844), 1500b.
[DOI: 10.1126/science.1138764] |Abstract »|Full Text »|PDF »|Supporting Online Material »
TECHNICAL COMMENTS
Giovanni Parmigiani, Jimmy Lin, Simina M. Boca, Tobias Sjöblom, Siân Jones, Laura D. Wood, D. Williams Parsons, Thomas Barber, Phillip Buckhaults, Sanford D. Markowitz, Ben Ho Park, Kurtis E. Bachman, Nickolas Papadopoulos, Bert Vogelstein, Kenneth W. Kinzler, and Victor E. Velculescu (14 September 2007) Science317 (5844), 1500d.
[DOI: 10.1126/science.1138773] |Abstract »|Full Text »|PDF »|Supporting Online Material »
RESEARCH ARTICLES
Tobias Sjöblom, Siân Jones, Laura D. Wood, D. Williams Parsons, Jimmy Lin, Thomas D. Barber, Diana Mandelker, Rebecca J. Leary, Janine Ptak, Natalie Silliman, Steve Szabo, Phillip Buckhaults, Christopher Farrell, Paul Meeh, Sanford D. Markowitz, Joseph Willis, Dawn Dawson, James K. V. Willson, Adi F. Gazdar, James Hartigan, Leo Wu, Changsheng Liu, Giovanni Parmigiani, Ben Ho Park, Kurtis E. Bachman, Nickolas Papadopoulos, Bert Vogelstein, Kenneth W. Kinzler, and Victor E. Velculescu (13 October 2006) Science314 (5797), 268.
[DOI: 10.1126/science.1133427] |Abstract »|Full Text »|PDF »|Supporting Online Material »
