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Science 9 May 2008:
Vol. 320. no. 5877, pp. 760 - 764
DOI: 10.1126/science.1152622
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Review

Toward an AIDS Vaccine

Bruce D. Walker1,2* and Dennis R. Burton3*

A quarter century of scientific discovery has been applied to developing an AIDS vaccine, yet this goal remains elusive. Specific characteristics of the virus, including the extreme genetic variability in circulating viral isolates worldwide, biological properties of HIV that impede immune attack, and a high mutation rate that allows for rapid escape from adaptive immune responses, render this a huge challenge. However, evidence of protection against AIDS viruses in animal models and control of HIV in humans under certain circumstances, together with scientific advances in understanding disease pathogenesis, provide a strong rationale and objective paths to continue the pursuit of an effective AIDS vaccine to stem the global epidemic.

1 Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
2 Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
3 The Scripps Research Institute, La Jolla, CA 92037, USA.

* To whom correspondence should be addressed. E-mail: bwalker{at}partners.org, burton{at}scripps.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Glycosylation of gp41 of Simian Immunodeficiency Virus Shields Epitopes That Can Be Targets for Neutralizing Antibodies.
E. Yuste, J. Bixby, J. Lifson, S. Sato, W. Johnson, and R. Desrosiers (2008)
J. Virol. 82, 12472-12486
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Importance of the V1/V2 Loop Region of Simian-Human Immunodeficiency Virus Envelope Glycoprotein gp120 in Determining the Strain Specificity of the Neutralizing Antibody Response.
M. E. Laird, T. Igarashi, M. A. Martin, and R. C. Desrosiers (2008)
J. Virol. 82, 11054-11065
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With Minimal Systemic T-Cell Expansion, CD8+ T Cells Mediate Protection of Rhesus Macaques Immunized with Attenuated Simian-Human Immunodeficiency Virus SHIV89.6 from Vaginal Challenge with Simian Immunodeficiency Virus.
M. Genesca, P. J. Skinner, J. J. Hong, J. Li, D. Lu, M. B. McChesney, and C. J. Miller (2008)
J. Virol. 82, 11181-11196
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HIV Vaccine Research: The Way Forward.
A. S. Fauci, M. I. Johnston, C. W. Dieffenbach, D. R. Burton, S. M. Hammer, J. A. Hoxie, M. Martin, J. Overbaugh, D. I. Watkins, A. Mahmoud, et al. (2008)
Science 321, 530-532
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)