Policy Forum

Maynard V. Olson

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The author is in the Department of Molecular Biotechnology, University of Washington, Seattle, WA 98195, USA. M. Olson, from the University of Washington, Seattle, expresses his view that the time has come to focus on large-scale sequencing of the human genome and to divert resources from such areas as technology development, analysis of gene function, and the launching of new model-organism projects.

An Effective Approach for Analyzing "Prefinished" Genomic Sequence Data.

P. M. Kuehl, J. M. Weisemann, J. W. Touchman, E. D. Green, and M. S. Boguski (1999)
Genome Res. 9, 189-194
 |  Abstract »  |  Full Text »

An Integrated Nanoliter DNA Analysis Device.

M. A. Burns, B. N. Johnson, S. N. Brahmasandra, K. Handique, J. R. Webster, M. Krishnan, T. S. Sammarco, P. M. Man, D. Jones, D. Heldsinger, et al. (1998)
Science 282, 484-487
 |  Abstract »  |  Full Text »

Automated high resolution optical mapping using arrayed, fluid-fixed DNA molecules.

J. Jing, J. Reed, J. Huang, X. Hu, V. Clarke, J. Edington, D. Housman, T. S. Anantharaman, E. J. Huff, B. Mishra, et al. (1998)
PNAS 95, 8046-8051
 |  Abstract »  |  Full Text »  |  PDF »

A Physical Map of Human Chromosome 7: An Integrated YAC Contig Map with Average STS Spacing of 79 kb.

G. G. Bouffard, J. R. Idol, V. V. Braden, L. M. Iyer, A. F. Cunningham, L. A. Weintraub, J. W. Touchman, R. M. Mohr-Tidwell, D. C. Peluso, R. S. Fulton, et al. (1997)
Genome Res. 7, 673-692
 |  Abstract »  |  Full Text »  |  PDF »

Multiple-complete-digest restriction fragment mapping: Generating sequence-ready maps for large-scale DNA sequencing.

G. K.-S. Wong, J. Yu, E. C. Thayer, and M. V. Olson (1997)
PNAS 94, 5225-5230
 |  Abstract »  |  Full Text »  |  PDF »

Human Whole-Genome Shotgun Sequencing.

J. L. Weber and E. W. Myers (1997)
Genome Res. 7, 401-409
 |  Full Text »  |  PDF »

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