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Science 3 November 1995:
Vol. 270. no. 5237, p. 713
DOI:

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Cytokine receptors are thought to produce their cellular effects in part by activating members of the Janus family of kinases (Jaks). The Jaks phosphorylate and activate transcription factors known as Stats. Three reports clarify the crucial biological roles of Jak3, which is activated by several members of the interleukin receptor family. Nosaka et al. (p. 800) and Thomis et al. (p. 794) describe mice that lack Jak3. Such mice have reduced numbers of B and T cells and associated defects in T and B cell function. Russell et al. (p. 797) describe a human patient who lacks Jak3 and suffers from X-linked severe combined immunodeficiency. The results indicate that Jak3 is essential for proper development of lymphoid cells.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)