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Science 10 November 1995:
Vol. 270. no. 5238, p. 932
DOI: 10.1126/science.270.5238.932
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Perspectives

James P. Allison, Matthew F. Krummel

The Perspective by J. Allison and M. Krummel discusses a paper in this issue of Science by Waterhouse et al. (p. 985), which reports the lymphoproliferative phenotype of mice lacking the T cell antigen CTLA-4. The function of this molecule has been elusive, but the pronounced lymphadenopathy of these knockout mice provides strong evidence that it works in opposition to the positive signal generated by the costimulatory T cell antigen receptor-peptide and CD28-B7 interactions.

The authors are in the Cancer Research Laboratory and Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. E-mail: jim_allison@maillink.berkeley.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)