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Science 17 November 1995:
Vol. 270. no. 5239, p. 1097
DOI:

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This Week in Science

Two reports focus on drugs to combat the replication of the human and simian immunodeficiency viruses. Rice et al. (p. 1194) have targeted a highly conserved structural motif of HIV-1, the zinc fingers of the nucleocapsid protein. Disulfide-substituted benzamides can modify the cysteine thiolates such that zinc no longer binds and the resulting virus is no longer infective. They identified nontoxic compounds that work well with other antiviral drugs in a cellular assay and that did not appear to induce resistant mutants. Tsai et al. (p. 1197; see the news story by Cohen, p. 1121) identified a drug that prevented SIV infection in macaques. An acyclic nucleoside phosphonate, PMPA, was given 2 days before or within 1 day after SIV exposure and then daily for 4 weeks. Unlike the control macaques, no infection was established.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)