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Science 17 November 1995:
Vol. 270. no. 5239, p. 1097
DOI:

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The two subsets of T cell helper cells, Tsubscript H1 and Tsubscript H2, differ in that they respond only to interleukin-12 or interferon-gamma (IFN-gamma), respectively, but not to the other cytokine. Bach et al. (p. 1215) show that this unresponsiveness is not intrinsically linked to differentiation but is rather a response of the cells to the cytokine. During Tsubscript H1 generation, IFN-gamma is produced that halts the expression of the IFN-gamma receptor beta subunit used in signaling. However, such beta subunit loss also occurred in Tsubscript H2 cells treated with IFN-gamma. Both subsets retained the ligand-binding alpha chain. Down-regulation of the signaling component of a receptor by its cytokine produced the unresponsive state.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)