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Science 17 November 1995:
Vol. 270. no. 5239, p. 1158
DOI: 10.1126/science.270.5239.1158
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Perspectives

J. Wayne Streilein

J. W. Streilein discusses the concept of immune privilege, which protects from rejection tissues grafted to certain sites in the body. The differences between immune-privileged sites and immune-privileged tissues are illustrated by two recent papers implicating the cell surface protein FasL in immune privilege in the eye (Science, p. 1189 of this issue) and in the testis [D. Bellgrau et al., Nature 377, 630 (1995)].

The author is in the Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA. E-mail: WayneS@vision.eri.harvard.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Overexpression of FasL in retinal pigment epithelial cells reduces choroidal neovascularization.
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Prolongation of Sheep Corneal Allograft Survival by Transfer of the Gene Encoding Ovine IL-12-p40 but Not IL-4 to Donor Corneal Endothelium.
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CD4-CD8 and CD28 Expression in T Cells Infiltrating the Vitreous Fluid in Patients With Proliferative Diabetic Retinopathy: A Flow Cytometric Analysis.
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Arch Ophthalmol 122, 743-749
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Tissue-Wide Expression Profiling Using cDNA Subtraction and Microarrays to Identify Tumor-Specific Genes.
S. Amatschek, U. Koenig, H. Auer, P. Steinlein, M. Pacher, A. Gruenfelder, G. Dekan, S. Vogl, E. Kubista, K.-H. Heider, et al. (2004)
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A Novel Mechanism of Alternative Promoter and Splicing Regulates the Epitope Generation of Tumor Antigen CML66-L.
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J. Immunol. 172, 651-660
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Ocular immune privilege: the eye takes a dim but practical view of immunity and inflammation.
J. W. Streilein (2003)
J. Leukoc. Biol. 74, 179-185
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Soluble Fas Ligand and Transforming Growth Factor {beta}2 in the Aqueous Humor of Patients With Endothelial Immune Reactions After Penetrating Keratoplasty.
T. Reinhard, H. Bonig, S. Mayweg, D. Bohringer, U. Gobel, and R. Sundmacher (2002)
Arch Ophthalmol 120, 1630-1635
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Organ-Specific Cytokine Polarization Induced by Adoptive Transfer of Transgenic T Cells.
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J. Immunol. 169, 5514-5521
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Restoration of spermatogenesis by lentiviral gene transfer: Offspring from infertile mice.
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Endotoxin-Neutralizing Antimicrobial Proteins of the Human Placenta.
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Oral Exposure to Alloantigen Generates Intragraft CD8+ Regulatory Cells.
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Apoptosis mediates decrease in cellularity during the regression of Arthus reaction in cornea.
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Br. J. Ophthalmol. 85, 613-618
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Resistance to Marek's Disease Herpesvirus-induced Lymphoma is Multiphasic and Dependent on Host Genotype.
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Vet. Pathol. 38, 129-142
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Relationships between Enterococcal Virulence and Antimicrobial Resistance.
L. M. Mundy, D. F. Sahm, and M. Gilmore (2000)
Clin. Microbiol. Rev. 13, 513-522
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T-Cell-Mediated Immune Responses in Alloepithelial Rejection after Murine Keratoepithelioplasty.
D. Miyazaki, Y. Inoue, Y.-F. Yao, A. A. Okada, Y. Shimomura, K. Hayashi, Y. Tano, and Y. Ohashi (1999)
Invest. Ophthalmol. Vis. Sci. 40, 2590-2597
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Characterization of a Novel Cis-element That Regulates Fas Ligand Expression in Corneal Endothelial Cells.
J. Zhang, B. Ma, A. Marshak-Rothstein, and A. Fine (1999)
J. Biol. Chem. 274, 26537-26542
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Characterization of the GAGE Genes That Are Expressed in Various Human Cancers and in Normal Testis.
O. De Backer, K. C. Arden, M. Boretti, V. Vantomme, C. De Smet, S. Czekay, C. S. Viars, E. De Plaen, F. Brasseur, P. Chomez, et al. (1999)
Cancer Res. 59, 3157-3165
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Differential T cell response in central and peripheral nerve injury: connection with immune privilege.
G. MOALEM, A. MONSONEGO, Y. SHANI, I. R. COHEN, and M. SCHWARTZ (1999)
FASEB J 13, 1207-1217
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TRAIL (Apo-2L) and TRAIL Receptors in Human Placentas: Implications for Immune Privilege.
T. A. Phillips, J. Ni, G. Pan, S. M. Ruben, Y.-F. Wei, J. L. Pace, and J. S. Hunt (1999)
J. Immunol. 162, 6053-6059
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Involvement of the Fas/Fas Ligand System in p53-Mediated Granulosa Cell Apoptosis during Follicular Development and Atresia.
J.-M. Kim, Y.-D. Yoon, and B. K. Tsang (1999)
Endocrinology 140, 2307-2317
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Paracrine Immunotherapy with Interleukin-2 and Local Chemotherapy Is Synergistic in the Treatment of Experimental Brain Tumors.
P. Sampath, J. Hanes, F. DiMeco, B. M. Tyler, D. Brat, D. M. Pardoll, and H. Brem (1999)
Cancer Res. 59, 2107-2114
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Fas and Fas Ligand Messenger Ribonucleic Acid and Protein Expression in the Rat Corpus Luteum during Apoptosis-Mediated Luteolysis.
S. A. Roughton, R. R. Lareu, A. H. Bittles, and A. M. Dharmarajan (1999)
Biol Reprod 60, 797-804
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Fas-FasL Interaction Involved in Pathogenesis of Ocular Toxoplasmosis in Mice.
M. S. Hu, J. D. Schwartzman, G. R. Yeaman, J. Collins, R. Seguin, I. A. Khan, and L. H. Kasper (1999)
Infect. Immun. 67, 928-935
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Induction of Specific T Cell Tolerance by Fas Ligand- Expressing Antigen-Presenting Cells.
H.-g. Zhang, X. Su, D. Liu, W. Liu, P. Yang, Z. Wang, C. K. Edwards, H. Bluethmann, J. D. Mountz, and T. Zhou (1999)
J. Immunol. 162, 1423-1430
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CTL Effector Function Within the Central Nervous System Requires CD4+ T Cells.
S. A. Stohlman, C. C. Bergmann, M. T. Lin, D. J. Cua, and D. R. Hinton (1998)
J. Immunol. 160, 2896-2904
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Apoptosis in Surgically Excised Choroidal Neovascular Membranes in Age-Related Macular Degeneration.
D. R. Hinton, S. He, and P. F. Lopez (1998)
Arch Ophthalmol 116, 203-209
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To Die or Not to Die: An Overview of Apoptosis and Its Role in Disease.
S. W. Hetts (1998)
JAMA 279, 300-307
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Expression of Fas ligand in liver metastases of human colonic adenocarcinomas.
K. Shiraki, N. Tsuji, T. Shioda, K. J. Isselbacher, and H. Takahashi (1997)
PNAS 94, 6420-6425
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Science. ISSN 0036-8075 (print), 1095-9203 (online)