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Science 8 December 1995:
Vol. 270. no. 5242, p. 1590
DOI: 10.1126/science.270.5242.1590
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Special

Rachel Nowak

The discovery of how DNA is wrapped around histone cores suggests the possibility that histones might have a role to play in regulating the activity of specific genes. That idea fell into disrepute, however, as a great deal of evidence pointed at the importance of the proteins called transcription factors for specific gene regulation. But within the past year or two, researchers have found that histones can have a targeted effect on genes, suppressing the activity of some, but not others, in a phenomenon called gene silencing.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)