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Science 15 December 1995:
Vol. 270. no. 5243, p. 1737
DOI:

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The nature of an immune response is governed by T helper (TH) cells. If TH1 cells dominate, cell-mediated immunity results, whereas a TH2 response can cause immunoglobulin E production, as occurs in allergic diseases. Much effort is currently focused on early events that can bias the response toward either the TH1 or TH2 type. Yoshimoto et al. (p. 1845) identified one such event. A small population of T cells, discriminated by the expression of the NK1.1 marker, produces interleukin-4 soon after antigen challenge. This cytokine helps establish conditions that favor development of a TH2 response.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)