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Science 4 October 1996:
Vol. 274. no. 5284, pp. 9 - 0
DOI: 10.1126/science.274.5284.9g
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Class II MHC molecules associate with invariant (Ii) chains, which act as chaperones for their folding and transport. Shachar and Flavell (p. 106) show that Ii is also essential for B cell maturation. In mice lacking Ii, peripheral B cells were immature and did not proliferate when stimulated by type II thymic-independent antigens. This block in development did not depend on expression of MHC class II molecules.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)