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Science 18 October 1996:
Vol. 274. no. 5286, pp. 317 - 0
DOI: 10.1126/science.274.5286.317f
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Certain strains of mice infected with Leishmania major develop a rapid protective response, but others develop a severe, ultimately fatal infection. Julia et al. (p. 421) show that the early T cell response to infection is crucial to the outcome. In susceptible strains, the response is dominated by a single antigen, known as LACK (Leishmania homolog of receptors for activated C kinase). This response is mediated by TH2 cells and is the mouse's downfall. If the immune system of susceptible mice is blinded to the LACK antigen (by expressing LACK in the thymus, so that LACK-reactive T cells do not develop), then TH1 responses develop to other Leishmania antigens, converting the susceptible mouse to a healer phenotype.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)