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Science 1 November 1996:
Vol. 274. no. 5288, pp. 697 - 0
DOI: 10.1126/science.274.5288.697f
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This Week in Science

How bacterial pathogens invade cells of their hosts is not well understood. Ireton et al. p. 780) found that the invasion of cells by Listeria monocytogenes, a bacterium that can cause food-borne infections in humans, requires the activity of the host enzyme phosphoinositide 3-kinase (PI 3-kinase). It is not clear how PI 3-kinase or its products contribute to the invasion process, but the enzyme is implicated in control of the cytoskeleton, phagocytosis, and endocytosis. The invading bacteria may commandeer the host cells' own apparatus that is normally used for endocytosis to gain transport into the cell.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)