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Science 1 November 1996:
Vol. 274. no. 5288, pp. 697 - 0
DOI: 10.1126/science.274.5288.697h
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Antibody production by B cells is initiated by antigen interactions with the B cell antigen receptor, which then sets off a cascade of protein tyrosine phosphorylation events. One surface glycoprotein that undergoes phosphorylation, CD22, is critical for controlling antigen responsiveness. O'Keefe et al. p. 798) show that B cells from the spleen of mice lacking CD22 respond to lower than normal antigen concentrations. They suggest that CD22 is a negative regulator of B cells that helps them respond to foreign antigens and avoid autoimmune responses.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)