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Science 1 November 1996:
Vol. 274. no. 5288, pp. 724 - 0
DOI: 10.1126/science.274.5288.724
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Research News

Marcia Barinaga

Three separate research groups report in this issue of Science (pages 782, 784, and 787 ) that a cellular protein called nuclear factor kappa B (NF-kappa B)blocks the programmed form of cell suicide known as apoptosis in several cell types. This finding has led to the suggestion that blocking NF-kappa B in tumor cells might make them more vulnerable to drugs or radiation.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The transcriptional program of terminal granulocytic differentiation.
K. Theilgaard-Monch, L. C. Jacobsen, R. Borup, T. Rasmussen, M. D. Bjerregaard, F. C. Nielsen, J. B. Cowland, and N. Borregaard (2005)
Blood 105, 1785-1796
   Abstract »    Full Text »    PDF »
Hydrogen Peroxide Signaling through Tumor Necrosis Factor Receptor 1 Leads to Selective Activation of c-Jun N-terminal Kinase.
C. Pantano, P. Shrivastava, B. McElhinney, and Y. Janssen-Heininger (2003)
J. Biol. Chem. 278, 44091-44096
   Abstract »    Full Text »    PDF »
Reactive Nitrogen Species and Cell Signaling: Implications for Death or Survival of Lung Epithelium.
Y. M. W. Janssen-Heininger, R. L. Persinger, S. H. Korn, C. Pantano, B. McElhinney, N. L. Reynaert, R. C. J. Langen, K. Ckless, P. Shrivastava, and M. E. Poynter (2002)
Am. J. Respir. Crit. Care Med. 166, S9-16
   Abstract »    Full Text »    PDF »
Angiotensin II and Renal Fibrosis.
S. A. Mezzano, M. Ruiz-Ortega, and J. Egido (2001)
Hypertension 38, 635-638
   Abstract »    Full Text »    PDF »
The heat shock paradox: does NF-{kappa}B determine cell fate?.
SUSAN. L. DeMEESTER, T. G. BUCHMAN, and J. P. COBB (2001)
FASEB J 15, 270-274
   Abstract »    Full Text »    PDF »
Bax is downregulated in inflamed colonic mucosa of ulcerative colitis.
M Iimura, T Nakamura, S Shinozaki, B Iizuka, Y Inoue, S Suzuki, and N Hayashi (2000)
Gut 47, 228-235
   Abstract »    Full Text »    PDF »
Angiotensin II Activates Nuclear Transcription Factor {kappa}B Through AT1 and AT2 in Vascular Smooth Muscle Cells : Molecular Mechanisms.
M. Ruiz-Ortega, O. Lorenzo, M. Ruperez, S. Konig, B. Wittig, and J. Egido (2000)
Circ. Res. 86, 1266-1272
   Abstract »    Full Text »    PDF »
Identification, Characterization, and Cloning of TIP-B1, a Novel Protein Inhibitor of Tumor Necrosis Factor-induced Lysis.
E. S. Berleth, S. Nadadur, A. D. Henn, C. Eppolito, S. Shiojiri, H. L. Gurtoo, M. J. Ehrke, and E. Mihich (1999)
Cancer Res. 59, 5497-5506
   Abstract »    Full Text »    PDF »
Pathways to Cell Death in Hyperoxia.
S. Horowitz (1999)
Chest 116, 64S-67S
   Full Text »    PDF »
The Virulence Plasmid of Yersinia, an Antihost Genome.
G. R. Cornelis, A. Boland, A. P. Boyd, C. Geuijen, M. Iriarte, C. Neyt, M.-P. Sory, and I. Stainier (1998)
Microbiol. Mol. Biol. Rev. 62, 1315-1352
   Abstract »    Full Text »    PDF »
Triggering of CD40 Antigen Inhibits Fludarabine-Induced Apoptosis in B Chronic Lymphocytic Leukemia Cells.
M. F. Romano, A. Lamberti, P. Tassone, F. Alfinito, S. Costantini, F. Chiurazzi, T. Defrance, P. Bonelli, F. Tuccillo, M. C. Turco, et al. (1998)
Blood 92, 990-995
   Abstract »    Full Text »    PDF »
NF-kappa B-dependent inhibition of apoptosis is essential for host cell survival during Rickettsia rickettsii infection.
D. R. Clifton, R. A. Goss, S. K. Sahni, D. van Antwerp, R. B. Baggs, V. J. Marder, D. J. Silverman, and L. A. Sporn (1998)
PNAS 95, 4646-4651
   Abstract »    Full Text »    PDF »
TRANCE Is a Novel Ligand of the Tumor Necrosis Factor Receptor Family That Activates c-Jun N-terminal Kinase in T Cells.
B. R. Wong, J. Rho, J. Arron, E. Robinson, J. Orlinick, M. Chao, S. Kalachikov, E. Cayani, F. S. Bartlett III, W. N. Frankel, et al. (1997)
J. Biol. Chem. 272, 25190-25194
   Abstract »    Full Text »    PDF »
Nuclear Factor-kappa B Is Activated by Hyperoxia but Does Not Protect from Cell Death.
Y. Li, W. Zhang, L. L. Mantell, J. A. Kazzaz, A. M. Fein, and S. Horowitz (1997)
J. Biol. Chem. 272, 20646-20649
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)