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Science 15 November 1996:
Vol. 274. no. 5290, pp. 1151 - 0
DOI: 10.1126/science.274.5290.1151
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Perspectives

Simeon I. Taylor, Valarie Barr, Marc Reitman

One of the consequences of obesity is an increased risk of non-insulin-dependent diabetes. Cohen et al. present evidence in this week's issue ( p. 1185) that this outcome may be mediated at least in part by leptin, a recently discovered drug that causes satiety. In their Perspective, Taylor et al. discuss this finding in the context of what is already known about insulin action and regulation of insulin resistance.

The authors are in the Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD 20892-1829, USA. E-mail: simeon_taylor{at}nih.gov

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Science. ISSN 0036-8075 (print), 1095-9203 (online)