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Science 29 November 1996:
Vol. 274. no. 5292, pp. 1464 - 1465
DOI: 10.1126/science.274.5292.1464
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Research News
Michael Balter
Varenna, Italy--Last month, more than 100 AIDS experts gathered here to contemplate a major unsolved riddle of HIV infection: What role do immune-system cells other than T lymphocytes play in the progression of the disease? Researchers reported that macrophages and dendritic cells may be an important site of virus production and may also be HIV's gateway to the brain, an accomplice in the killing of T cells, and the refuge of HIV strains with different susceptibilities to antiviral drugs.
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Peroxisome Proliferator-activated Receptor gamma Agonists Inhibit HIV-1 Replication in Macrophages by Transcriptional and Post-transcriptional Effects.
- M. M. Hayes, B. R. Lane, S. R. King, D. M. Markovitz, and M. J. Coffey (2002)
J. Biol. Chem.
277, 16913-16919
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- Perivascular Macrophages Are the Primary Cell Type Productively Infected by Simian Immunodeficiency Virus in the Brains of Macaques: Implications for the Neuropathogenesis of AIDS.
- K. C. Williams, S. Corey, S. V. Westmoreland, D. Pauley, H. Knight, C. deBakker, X. Alvarez, and A. A. Lackner (2001)
J. Exp. Med.
193, 905-916
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- Opposite Effects of IL-10 on the Ability of Dendritic Cells and Macrophages to Replicate Primary CXCR4-Dependent HIV-1 Strains.
- P. Ancuta, Y. Bakri, N. Chomont, H. Hocini, D. Gabuzda, and N. Haeffner-Cavaillon (2001)
J. Immunol.
166, 4244-4253
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- Signaling Through the Lymphotoxin-{beta} Receptor Stimulates HIV-1 Replication Alone and in Cooperation with Soluble or Membrane-Bound TNF-{alpha}.
- W. L. Marshall, B. M. N. Brinkman, C. M. Ambrose, P. A. Pesavento, A. M. Uglialoro, E. Teng, R. W. Finberg, J. L. Browning, and A. E. Goldfeld (1999)
J. Immunol.
162, 6016-6023
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- Dendritic Cells Route Human Immunodeficiency Virus to Lymph Nodes after Vaginal or Intravenous Administration to Mice.
- C. Masurier, B. Salomon, N. Guettari, C. Pioche, F. Lachapelle, M. Guigon, and D. Klatzmann (1998)
J. Virol.
72, 7822-7829
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- Identification of a Novel Domain of HIV Tat Involved in Monocyte Chemotaxis.
- A. Albini, R. Benelli, D. Giunciuglio, T. Cai, G. Mariani, S. Ferrini, and D. M. Noonan (1998)
J. Biol. Chem.
273, 15895-15900
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- Decreased ability of HIV-1 Tat protein-treated accessory cells to organize cellular clusters is associated with partial activation of T cells.
- M. X. Wu and S. F. Schlossman (1997)
PNAS
94, 13832-13837
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- SH3-mediated Hck Tyrosine Kinase Activation and Fibroblast Transformation by the Nef Protein of HIV-1.
- S. D. Briggs, M. Sharkey, M. Stevenson, and T. E. Smithgall (1997)
J. Biol. Chem.
272, 17899-17902
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- HIV-1 Nef Promotes Survival of Myeloid Cells by a Stat3-dependent Pathway.
- S. D. Briggs, B. Scholtz, J.-M. Jacque, S. Swingler, M. Stevenson, and T. E. Smithgall (2001)
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276, 25605-25611
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