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Science 6 December 1996:
Vol. 274. no. 5293, pp. 1585 - 0
DOI: 10.1126/science.274.5293.1585e
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This Week in Science

Some DNA viruses, such as herpesviruses, are known to acquire host cell genes. Kaposi's sarcoma-associated herpesvirus (KSHV) is the probable causative agent of KS both in the presence and absence of co-infection with human immunodeficiency virus-type 1 (HIV-1), and Moore et al. (p. 1739) have sequenced KSHV genes that encode four viral proteins similar to two human macrophage inflammatory protein (MIP) chemokines, interleukin-6, and interferon regulatory factor. The virally encoded MIP-1, like the human form, inhibits replication of HIV-1 strains dependent on the CCR5 co-receptor. Such viral gene products may interfere with the host cell's defenses.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)