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Science 13 December 1996:
Vol. 274. no. 5294, pp. 1813 - 0
DOI: 10.1126/science.274.5294.1813g
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Expression of cytokines such as interleukin-4 (IL-4) requires several transcription factors, including members of the NF-AT family (nuclear factor of activated T cells), but low levels of cytokine expression in reconstituted systems suggests that unknown proteins act in NF-AT-mediated transcription. Hodge et al (p. 1903) have now identified a protein, NIP45, that shows little similarity to other known proteins, but that, in combination with the NF-AT protein and c-maf, activated the IL-4 promoter. Transient overexpression of these proteins in B cells led to endogenous production of IL-4.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)