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Science 20 December 1996:
Vol. 274. no. 5295, pp. 1983 - 0
DOI: 10.1126/science.274.5295.1983h
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T cell receptors (TCRs) "see" foreign peptides complexed with either class I or class II major histocompatibility complex (MHC) proteins. Natural killer (NK) cells do not express TCRs but have activating and inhibitory receptors that bind to class I MHC molecules. Mandelboim et al. (p. 2097) studied such T cell clones that express the NK cell activating receptor (NKAR1). These T cells were isolated during NK cell cloning and were restricted to MHC class II responses. Proliferation of these T cells in response to superantigens increased by 300 to 900% in situations where the NKAR1 receptor could bind class I. This costimulation by class I proteins could help T cells initiate immune responses in the presence of limiting amounts of antigen.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)