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Science 20 December 1996:
Vol. 274. no. 5295, pp. 2008 - 2009
DOI: 10.1126/science.274.5295.2008b
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Research News

Elizabeth Pennisi

San Francisco--Because individuals who have Down syndrome have extra copies of all or part of chromosome 21, researchers have had trouble linking the many problems they suffer to any particular genes. Now several teams have evidence that the mental retardation in Down syndrome is at least partly caused by extra copies of a gene encoding an enzyme known as DYRK (for dual specificity tyrosine phosphorylation-regulated kinase) that is apparently involved in brain development.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)