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Science 20 December 1996:
Vol. 274. no. 5295, pp. 2009 - 0
DOI: 10.1126/science.274.5295.2009
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Research News

Robert F. Service

Two groups have synthesized a bacterial compound known as Epothilone A, which kills cultured tumor cells in a manner similar to taxol, thwarting their ability to divide. The achievement will let chemists alter the compound's structure and possibly improve its properties.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel.
T.-C. Chou, X.-G. Zhang, C. R. Harris, S. D. Kuduk, A. Balog, K. A. Savin, J. R. Bertino, and S. J. Danishefsky (1998)
PNAS 95, 15798-15802
   Abstract »    Full Text »    PDF »
Desoxyepothilone B: An efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B.
T.-C. Chou, X.-G. Zhang, A. Balog, D.-S. Su, D. Meng, K. Savin, J. R. Bertino, and S. J. Danishefsky (1998)
PNAS 95, 9642-9647
   Abstract »    Full Text »    PDF »
A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.
P. Giannakakou, R. Gussio, E. Nogales, K. H. Downing, D. Zaharevitz, B. Bollbuck, G. Poy, D. Sackett, K. C. Nicolaou, and T. Fojo (2000)
PNAS 97, 2904-2909
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)